ReliOn/Novolin NPH | |
---|---|
NPH/Isophane by Novo Nordisk | |
intermediate-acting | |
r-DNA/GE/GM | |
U40, U100 | isophane |
Action in dogs: | |
Line: Novolin | |
Also known as: Novolin N, Insulatard, Protaphan, Protaphane | |
Similar to: Humulin I, Huminsulin Basal, Humulin N, Humulin NPH, Humulina NPH, Humuline NPH, Humuline N, Umuline NPH, Humulin ReliOn N Insuhuman Basal, Winthrop Basal Insuman Basal, Isuhuman Basal Names of Lilly r-DNA/GE/GM insulins worldwide | |
Use and Handling: | |
Shelf Life: 30 months | Type: cloudy |
When Opened: 6 weeks room temp. | |
In Pen: 6 weeks room temp. | |
Notes: Protect from light and heat Do Not Freeze, Resuspend Do not use if product does not re-suspend Do not use intravenously [3] |
An NPH/isophane crystal insulin. [4][5] As of October 2010, ReliOn brand insulin was no longer made by Novo Nordisk, who had been responsible for producing the ReliOn insulins since 2000. [6][7] The ReliOn insulins are still offered in the same types, R, NPH, and 70/30 mix, but they are produced by Eli Lilly and branded as Humulin/ReliOn insulins. [8][9][10] Novolin insulins have NOT been discontinued; these insulins are available as Novolin N, Novolin R, and Novolin 70/30. Only the ReliOn/Novolin branded insulins have been phased out.
This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.
It was a protamine suspension insulin, made by Novo Nordisk especially for Wal-Mart and Sam's Club. [11][12]
The only difference between the vials was the addition of the ReliOn name and the cheaper price. There was no quality difference between this insulin and Novolin N. [13], Insulatard or Protaphane [14]
Other comparable insulins by other manufacturers are: Umuline NPH, Humuline NPH, Humulina NPH, Huminsulin Basal, Humulin N, [15][16] Humulin I, [17]--the "I" an abbreviation for isophane, [18][19] Insuman Basal, [20][21] and Winthrop Basal.
Specifications of NPH/isophane insulin[]
British National Formulary [22] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.
British Pharmacoepia and United States Pharmacopia definitions: [23]
Isophane Insulin
Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.
USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.
NPH/isophane insulins[]
The following commercial insulins are all generically NPH insulins:
NPH/Isophane Insulins | |
---|---|
All Intermediate acting | |
Betasint Bovine NPH Hypurin Bovine Isophane [24][25][26] | |
Iletin NPH
(No longer produced.) | |
Iletin I NPH
(No longer produced.) | |
Betasint Porcine NPH Hypurin Porcine Isophane [27][28] Hypurin Pork NPH | |
Iletin II NPH (No longer produced.) Pork Insulatard [29][30][31] (No longer produced.) Leo Retard (No longer produced.) | |
Huminsulin Basal, Humulin I Humulin N, Humulin NPH Humulina NPH, Humuline N Humuline NPH, Umuline NPH Humulin ReliOn N | |
Insuhuman Basal, Insuman Basal Isuhuman Basal, Winthrop Basal | |
Insulatard, Novolin N Protaphan, Protaphane | |
ReliOn/Novolin NPH (No longer produced) |
Other commonly used names are:
- NPH insulin, NPH
- isophane insulin
References[]
- ↑ Insulins. North American Veterinary Conference (2005).
- ↑ Ruchinsky, Renee, et. al. (2010). Diabetes Management Guidelines for Dogs and Cats-page 7. American Animal Hospital Association.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Scientific Discussion-Insulatard. EMEA.
- ↑ Prescribing Novo Insulins.
- ↑ A Change to ReliOn Insulin. ReliOn.
- ↑ Low Cost Insulin Available through major retailer. Diabetes Health (1 December 2000).
- ↑ Wal-Mart Changes Insulin Partners. Wall Street Journal (22 June 2010).
- ↑ Wal-Mart Press Release (22 June 2010).
- ↑ ReliOn insulins. ReliOn.
- ↑ ReliOn/Novolin insulins.
- ↑ ReliOn/Novolin NPH.
- ↑ Novolin N. Revolution Health.
- ↑ Scientific Discussion-Protaphane. EMEA.
- ↑ Humulin N. Eli Lilly.
- ↑ Humulin N NPH/Isophane Insulin. Revolution Health.
- ↑ Humulin I Prescribing Information.
- ↑ Patient Information Leaflet-Humulin I. Eli Lilly.
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Patient Information Leaflet-Insuman Basal. Sanofi-Aventis.
- ↑ Insuman Prescribing Information.
- ↑ British National Formulary-Isophane/NPH Insulin Definition. InChem.
- ↑ British Pharmacoepia (BP) & United States Pharmacoepia (USP)-Isophane/NPH Insulin Defined. InChem.
- ↑ Hypurin Bovine Isophane Patient Information. Net Doctor.co.uk.
- ↑ Hypurin Bovine Isophane. Wockhardt UK.
- ↑ Prescribing Bovine Insulin.
- ↑ Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
- ↑ Prescribing Porcine Insulin.
- ↑ Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
- ↑ Prescribing Novo Animal Insulin.
- ↑ Patient Information Leaflet-Pork Insulatard. Novo Nordisk.
More Information[]
- NACDS-Insulin Chart-Page 2
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of NPH/isophane insulins.
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