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| colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Line:''' [[Humulin]] |
| colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Line:''' [[Humulin]] |
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| − | | colspan="2" style="background:aliceblue; width:300px; font-size:9pt;text-align:left"| '''Also known as:''' [[Huminsulin Profil IV]], [[Humulin 40/60]], [[Humulina 40/60]], [[Humuline 40/60]], [[Humulin M4]]<br>[[Umuline Profil 40]] |
+ | | colspan="2" style="background:aliceblue; width:300px; font-size:9pt;text-align:left"| '''Also known as:''' [[Huminsulin Profil IV]], [[Humulin 40/60]], [[Humulina 40/60]], [[Humuline 40/60]], [[Humulin M4]]<br>[[Umuline Profil 40]], [[Humulin 60/40]] |
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| colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''Similar to:''' [[Actraphane 40/60]], [[Mixtard 40]],<br> [[Penmix 40]] <ref>{{cite web|url=http://www.medsafe.govt.nz/Profs/DataSheet/PenmixMixtardProtaphaneinj.htm |title=Penmix 40|publisher=Medsafe NZ}}</ref><br><br>[http://images3.wikia.nocookie.net/__cb20100602042136/diabetesindogs/images/2/23/WW_Humuline.pdf Names of Lilly r-DNA/GE/GM insulins worldwide] |
| colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''Similar to:''' [[Actraphane 40/60]], [[Mixtard 40]],<br> [[Penmix 40]] <ref>{{cite web|url=http://www.medsafe.govt.nz/Profs/DataSheet/PenmixMixtardProtaphaneinj.htm |title=Penmix 40|publisher=Medsafe NZ}}</ref><br><br>[http://images3.wikia.nocookie.net/__cb20100602042136/diabetesindogs/images/2/23/WW_Humuline.pdf Names of Lilly r-DNA/GE/GM insulins worldwide] |
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|colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''In Pen:''' 28 days room temp. |
|colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''In Pen:''' 28 days room temp. |
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| − | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''Notes:''' Protect from light and heat<br> Do Not Freeze, [[Resuspending insulin|Resuspend]]<br> Do not use if product does not [[re-suspend]]<br>Do not use [[intravenously]] |
+ | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''Notes:''' Protect from light and heat<br> Do Not Freeze, [[Resuspending insulin|Resuspend]]<br> Do not use if product does not [[re-suspend]]<br>Do not use [[intravenously]] <ref>{{cite web|title=Small Animal Clinical Pharmacology|author=Maddison, Jill E.,Page, Stephen W.,Church, David B.|year=2008|publisher=Saunders Ltd.|isbn=0702028584|page=510|url=http://www.amazon.com/Animal-Clinical-Pharmacology-Maddison-DipVetClinStud/dp/0702028584/ref=sr_1_1?s=books&ie=UTF8&qid=1296451134&sr=1-1}}</ref> |
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'''Note that some countries have the brand name in U40 strength.''' |
'''Note that some countries have the brand name in U40 strength.''' |
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| − | An intermediate-acting, mixed insulin like [[Humulin 40/60]], [[Humuline 40/60]], [[Humulin M4]], [[Humulina 40/60]], [[Penmix 40]] and [[Mixtard 40]] <ref>{{cite web|url=http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Novo_insulins.htm |title=Prescribing Novo Insulins}}</ref> of 40% R/neutral insulin and 60% NPH/isophane insulin<ref>{{cite web|url=http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20H)/HUMULIN.html |publisher=RxMed |title=Humulin 40/60}}</ref> made by [[Eli Lilly]] for North America. Huminsulin Profil IV, like [[Mixtard 40]] <ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000428/WC500029819.pdf|title=Scientific Discussion-Mixtard|publisher=EMEA}}</ref> contains 60% [[isophane]] insulin crystals. |
+ | An intermediate-acting, mixed insulin like [[Humulin 40/60]], [[Humuline 40/60]], [[Humulin M4]], [[Humulina 40/60]], [[Penmix 40]] and [[Mixtard 40]] <ref>{{cite web|url=http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Novo_insulins.htm |title=Prescribing Novo Insulins}}</ref> of 40% R/neutral insulin and 60% NPH/isophane insulin <ref>{{cite web|url=http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20H)/HUMULIN.html |publisher=RxMed |title=Humulin 40/60}}</ref> made by [[Eli Lilly]] for North America. Huminsulin Profil IV, like [[Mixtard 40]] <ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000428/WC500029819.pdf|title=Scientific Discussion-Mixtard|publisher=EMEA}}</ref> contains 60% [[isophane]] insulin crystals. |
Mixtard 40 was discontinued December 31, 2007. <ref>{{cite web|url=http://www.ukmicentral.nhs.uk/therapeu/pace/PACE0604.pdf |title=Insulin Discontinuations-UK|publisher=NHS}}</ref><ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/A4Humandis.pdf|title= Chart of Discontinued Novo Human Insulins|publisher=Novo Nordisk}}</ref> Humulin 40/60 is also no longer available. |
Mixtard 40 was discontinued December 31, 2007. <ref>{{cite web|url=http://www.ukmicentral.nhs.uk/therapeu/pace/PACE0604.pdf |title=Insulin Discontinuations-UK|publisher=NHS}}</ref><ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/A4Humandis.pdf|title= Chart of Discontinued Novo Human Insulins|publisher=Novo Nordisk}}</ref> Humulin 40/60 is also no longer available. |
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==References== |
==References== |
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Latest revision as of 23:22, 23 May 2012
| Profil 40 | |
|---|---|
| R/Neutral/NPH/Isophane Mix by Eli Lilly | |
| intermediate-acting | |
| r-DNA/GE/GM | |
| U40, U100 | isophane |
Action in dogs:
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| Line: Humulin | |
| Also known as: Huminsulin Profil IV, Humulin 40/60, Humulina 40/60, Humuline 40/60, Humulin M4 Umuline Profil 40, Humulin 60/40 | |
| Similar to: Actraphane 40/60, Mixtard 40, Penmix 40 [1] Names of Lilly r-DNA/GE/GM insulins worldwide | |
| Use and Handling: | |
| Shelf Life: 24 months | Type: cloudy |
| When Opened: 28 days room temp. | |
| In Pen: 28 days room temp. | |
| Notes: Protect from light and heat Do Not Freeze, Resuspend Do not use if product does not re-suspend Do not use intravenously [2] | |
Time activity profile for 40/60 insulin.
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Note that some countries have the brand name in U40 strength. | ||
An intermediate-acting, mixed insulin like Humulin 40/60, Humuline 40/60, Humulin M4, Humulina 40/60, Penmix 40 and Mixtard 40 [3] of 40% R/neutral insulin and 60% NPH/isophane insulin [4] made by Eli Lilly for North America. Huminsulin Profil IV, like Mixtard 40 [5] contains 60% isophane insulin crystals.
Mixtard 40 was discontinued December 31, 2007. [6][7] Humulin 40/60 is also no longer available.
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
| Non-Analog Mixed Insulins | ||
|---|---|---|
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All Intermediate-acting | |
| Insulin Is | Expressed As | Expressed As |
| 10% R/Neutral Insulin 90% NPH/Isophane Insulin |
90/10 | 10/90 |
| 20% R/Neutral Insulin 80% NPH/Isophane Insulin |
80/20 | 20/80 |
| 30% R/Neutral Insulin 80% NPH/Isophane Insulin |
70/30 | 30/70 |
| 40% R/Neutral Insulin 60% NPH/Isophane Insulin |
60/40 | 40/60 |
| 50% R/Neutral Insulin 50% NPH/Isophane Insulin |
50/50 | 50/50 |
References[]
- ↑ Penmix 40. Medsafe NZ.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Prescribing Novo Insulins.
- ↑ Humulin 40/60. RxMed.
- ↑ Scientific Discussion-Mixtard. EMEA.
- ↑ Insulin Discontinuations-UK. NHS.
- ↑ Chart of Discontinued Novo Human Insulins. Novo Nordisk.
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