Canine Diabetes Wiki
Pork Insulatard [1]
NPH/isophane by Novo Nordisk
U40, U100 isophane
Action in dogs:
  • onset within 2h,
  • peak 6-12h,
  • duration 18-14h
Line: Novo
Also known as: Leo Retard [2], pork NPH, pork isophane
Similar to: Betasint Porcine NPH
Hypurin Porcine Isophane, Hypurin Pork NPH
Iletin II NPH
Use and Handling:
Shelf Life: 36 months Type: cloudy
When Opened: 6 weeks room temp.
In Pen: 6 weeks room temp.
Notes: Protect from light and heat
Do Not Freeze, Re-suspend
Do not use if product does not re-suspend

Cartridges in use are not to be refrigerated
Do not use intravenously [3]
May be used intramuscularly, which means onset, peak and duration times are shorter.

Pork Insulatard

Pork Insulatard insulin.

Note that some countries have the brand name in U40 strength.

Pork Insulatard was a porcine NPH/Isophane insulin [4][5] made by Novo Nordisk.

It is similar to CP Pharma's Hypurin Porcine Isophane, [6][7] to Beta's Betasint Porcine NPH and to the now-defunct Eli Lilly product Iletin II NPH[8][9][10]

Like all other isophane/protamine suspended insulins, [11] it is a crystalline suspension with protamine and zinc.

After December, 2007, Novo Nordisk no longer offered this insulin in the UK; [12][13][14][15][16] according to the Novo Nordisk Australasia Home Page, [17] it was discontinued there by December, 2006. Those using it now order Hypurin Porcine Isophane from CP Pharma [18] or Betasint Porcine NPH from Beta Laboratorios.

Specifications of NPH/isophane insulin[]

Human Activity Profiles Various Insulins

Time activity profile for Pork Insulatard.


Novo discontinued pork insulins; Pork Insulatard is at right, with the green cap .

British National Formulary [19] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.

British Pharmacoepia and United States Pharmacopia definitions: [20]

Isophane Insulin

Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.

USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.

NPH/isophane insulins[]

The following commercial insulins are all generically NPH insulins:

Other commonly used names are:

  • NPH insulin, NPH
  • isophane insulin


  1. Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
  2. Montgomery, D. A. D.. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  3. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  4. Pork Insulatard Patient Information. Net
  5. Patient Information Leaflet-Pork Insulatard. Novo Nordisk.
  6. Hypurin Porcine Isophane. Wockhardt UK.
  7. Hypurin Porcine Isophane Patient Information. Net
  8. Iletin II N Discontinuation. US Food and Drug Administration (July 2005).
  9. Prescribing Novo Animal Insulins.
  10. Prescribing Porcine Insulins.
  11. Humulin N. Eli Lilly.
  12. Novo Pork Insulin Discontinuation Information. Wockhardt UK.
  13. Insulin Discontinuations--UK. NHS.
  14. Novo Nordisk Discontinues Animal Insulin Worldwide. Forum Insulin Schweiz.
  15. Pork Insulin Discontinuation Notice. NovoNordisk UK.
  16. Novo Pork Insulin Discontinuations. Novo Nordisk (2007).
  17. Novo Nordisk Australasia Home Page--Novo Pork Insulin Discontinuation. Novo Nordisk.
  18. Wockhardt/Hypurin Insulin Substitutes. NHS.
  19. British National Formulary-Isophane/NPH Insulin Definition. InChem.
  20. British Pharmacoepia (BP) & United States Pharmacoepia (USP)-Isophane/NPH Insulin Defined. InChem.
  21. Hypurin Bovine Isophane Patient Information. Net
  22. Hypurin Bovine Isophane. Wockhardt UK.
  23. Prescribing Bovine Insulin.
  24. Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
  25. Prescribing Porcine Insulin.
  26. Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
  27. Prescribing Novo Animal Insulin.
  28. Patient Information Leaflet-Pork Insulatard. Novo Nordisk.

More Information[]

Related Pages
Hypurin pork n
Iletin II N
Hypurin Porcine Isophane
Betasint Porcine NPH