| Pork Actrapid | |
|---|---|
| R, Neutral by Novo Nordisk | |
| short-acting | |
| Porcine | |
| U40, U100 | none |
Action in dogs:
| |
| Line: Novo | |
| Also known as: Leo Neutral,[1] Pork R, pork neutral | |
| Similar to: Betasint Porcine Corriente Hypurin Porcine Neutral, [2] Hypurin Pork Regular Maxirapid CHO, Iletin II R | |
| Use and Handling: | |
| Shelf Life: 36 months | Type: soluble, clear |
| When Opened: 6 weeks room temp. | |
| In Pen: N/A | |
| Notes: Protect from light and heat Do Not Freeze, May be used intravenously May be used intramuscularly | |
Pork Actrapid.
|
Note that some countries have the brand name in U40 strength. | ||
A short-acting, soluble R/neutral pork insulin which was made by Novo Nordisk. [3][4][5]
Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed. [6]
It is comparable to Iletin II R, [7] formerly made by Eli Lilly, Hypurin Porcine Neutral/Hypurin Pork Regular by CP Pharma, [8][9][10][11] Betasint Porcine Corriente by Beta Laboratorios and Maxirapid CHO by Polfa Tarchomin.
Novo's discontinued pork insulins; Pork Actrapid is at left with a yellow cap.
Novo Nordisk no longer offered this insulin after December 2007. [12][13][14][15][16]; according to the Novo Nordisk Australasia Home Page [17], it was discontinued there by December, 2006. It's now necessary to use Hypurin Porcine Neutral from CP Pharma [18]
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [19] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [20]
The very small insulin particles in semilente insulin are suspended by zinc .[21]. Semilente is cloudy, has an acetate buffer and cannot be used intravenously
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [22][23] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [24]
R/Neutral Insulins[]
|
R/Neutral Insulins | |
|---|---|
|
All Short acting All soluble |
| Hypurin Bovine Neutral Betasint Bovine Corriente | |
| Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) Insuvet Neutral (No longer produced.) | |
| Iletin I R (No longer produced.) | |
| Hypurin Porcine Neutral Hypurin Pork Regular Betasint Porcine Corriente, Maxirapid CHO | |
| Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
| Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, Umuline Rapide Umuline Regular, Winthrop Rapid Humulin ReliOn R | |
| R-DNA | ReliOn/Novolin R (No longer produced.) |
References[]
- ↑ Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
- ↑ Response to Withdrawal of Novo Porcine Insulin Range. CP/Wockhardt UK.
- ↑ Pork Actrapid Patient Information. Net Doctor.co.uk.
- ↑ Patient Information Leaflet-Pork Actrapid. Novo Nordisk.
- ↑ Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
- ↑ Humulin R. Eli Lilly.
- ↑ Iletin II R Discontinuation Notice. US Food and Drug Administration (July 2005).
- ↑ Hypurin Porcine Neutral. Wockhardt UK.
- ↑ Hypurin Porcine Neutral Patient Information. Net Doctor.co.uk.
- ↑ Prescribing Novo Animal Insulins.
- ↑ Prescribing Porcine Insulin.
- ↑ Novo Pork Insulins Discontinuation Information. Novo Nordisk.
- ↑ Novo Nordisk Discontinues Animal Insulins Worldwide. Forum Insulin Schweiz.
- ↑ Pork Insulin Discontinuation Notice. NovoNordisk UK.
- ↑ Insulin Discontinuations-UK. NHS.
- ↑ Novo Pork Insulin Discontinuations. Novo Nordisk (2007).
- ↑ Novo Nordisk Australasia Home Page--Novo Pork Insulin Discontinuation. Novo Nordisk.
- ↑ Wockhardt/Hypurin Insulin Substitutes. NHS.
- ↑ DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ DeRuiter, Jack. Insulin Preparations-Lente. Auburn University.
- ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
Note--in 1980, there were no r-DNA/GE/GM insulins - ↑ Resource Guide. American Diabetes Association (2005).
- ↑ DeRuiter, Jack. Insulin Preparations-Lente Insulin. Auburn University.
More Information[]
- NACDS-Insulin Chart-Page 2
- Insulin therapy for dogs and cats Dowling, Pareicia, September 1995, Canadian Veterinary Journal
A discussion of Iletin insulins. - Insulin pork regular
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