Canine Diabetes Wiki
Pork Actrapid
R, Neutral by Novo Nordisk
U40, U100 none
Action in dogs:
  • onset 30-60 minutes,
  • peak 2-4h,
  • duration 6-8h
Line: Novo
Also known as: Leo Neutral,[1] Pork R, pork neutral
Similar to: Betasint Porcine Corriente
Hypurin Porcine Neutral, [2] Hypurin Pork Regular
Maxirapid CHO, Iletin II R
Use and Handling:
Shelf Life: 36 months Type: soluble, clear
When Opened: 6 weeks room temp.
In Pen: N/A
Notes: Protect from light and heat
Do Not Freeze,
May be used intravenously
May be used intramuscularly
Pork Actrapid

Pork Actrapid.

Note that some countries have the brand name in U40 strength.

A short-acting, soluble R/neutral pork insulin which was made by Novo Nordisk. [3][4][5]

Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed. [6]

It is comparable to Iletin II R, [7] formerly made by Eli Lilly, Hypurin Porcine Neutral/Hypurin Pork Regular by CP Pharma, [8][9][10][11] Betasint Porcine Corriente by Beta Laboratorios and Maxirapid CHO by Polfa Tarchomin.


Novo's discontinued pork insulins; Pork Actrapid is at left with a yellow cap.

Novo Nordisk no longer offered this insulin after December 2007. [12][13][14][15][16]; according to the Novo Nordisk Australasia Home Page [17], it was discontinued there by December, 2006. It's now necessary to use Hypurin Porcine Neutral from CP Pharma [18]

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [19] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [20]

The very small insulin particles in semilente insulin are suspended by zinc .[21]. Semilente is cloudy, has an acetate buffer and cannot be used intravenously

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [22][23] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [24]

R/Neutral Insulins[]


  1. Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  2. Response to Withdrawal of Novo Porcine Insulin Range. CP/Wockhardt UK.
  3. Pork Actrapid Patient Information. Net
  4. Patient Information Leaflet-Pork Actrapid. Novo Nordisk.
  5. Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  6. Humulin R. Eli Lilly.
  7. Iletin II R Discontinuation Notice. US Food and Drug Administration (July 2005).
  8. Hypurin Porcine Neutral. Wockhardt UK.
  9. Hypurin Porcine Neutral Patient Information. Net
  10. Prescribing Novo Animal Insulins.
  11. Prescribing Porcine Insulin.
  12. Novo Pork Insulins Discontinuation Information. Novo Nordisk.
  13. Novo Nordisk Discontinues Animal Insulins Worldwide. Forum Insulin Schweiz.
  14. Pork Insulin Discontinuation Notice. NovoNordisk UK.
  15. Insulin Discontinuations-UK. NHS.
  16. Novo Pork Insulin Discontinuations. Novo Nordisk (2007).
  17. Novo Nordisk Australasia Home Page--Novo Pork Insulin Discontinuation. Novo Nordisk.
  18. Wockhardt/Hypurin Insulin Substitutes. NHS.
  19. DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University.
  20. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  21. DeRuiter, Jack. Insulin Preparations-Lente. Auburn University.
  22. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  23. Resource Guide. American Diabetes Association (2005).
  24. DeRuiter, Jack. Insulin Preparations-Lente Insulin. Auburn University.

More Information[]

Related pages
Hypurin pork r
Insulinum Maxrapid 400px
Betasint Porcine Corriente
Iletin II R
Hypurin Porcine Neutral
Maxirapid CHO