| Novolin R | |
|---|---|
| R, Neutral by Novo Nordisk | |
| short-acting | |
| r-DNA/GE/GM | |
| U100 | none |
Action in dogs:
| |
| Line: Novolin | |
| Also known as: Actrapid, ReliOn/Novolin R | |
| Similar to: Huminsulin Normal, Humulin C Humulin R, Humuline R, Humulin Regular Humulina Regular, Humuline Regular, Humulin S Humulin ReliOn R, Umuline Rapide Umuline Regular, Insuman Rapid, Winthrop Rapid Names of Lilly r-DNA/GE/GM insulins worldwide | |
| Use and Handling: | |
| Shelf Life: 24 months | Type: soluble, clear |
| When Opened: 6 weeks room temp. | |
| In Pen: 6 weeks room temp. | |
| Notes: Protect from light and heat Do Not Freeze, May be used intravenously | |
Novolin R--Regular/Neutral GE insulin.
Novo Nordisk's brand of "R"-action insuln is known by three names: Actrapid [2][3][4] in Europe:
ReliOn/Novolin R and Novolin R in North America.
As of January 1, 2010, Novo discontinued offering Novolin R in cartridges for refillable insulin pens. [5][6]
Other companies make similar products--they are: Huminsulin Normal, Humulin R [7][8] and Humulin S [9][10][11] by Eli Lilly and Insuman Rapid [12][13] and Winthrop Rapid both by Aventis.
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [14] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [15]
The very small insulin particles in semilente insulin are suspended by zinc. [16] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [17][18]. Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin [19]
R/Neutral Insulins[]
|
R/Neutral Insulins | |
|---|---|
|
All Short acting All soluble |
| Hypurin Bovine Neutral Betasint Bovine Corriente | |
| Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.). Insuvet Neutral (No longer produced.) | |
| Iletin I R (No longer produced.) | |
| Betasint Porcine Corriente Hypurin Porcine Neutral Hypurin Pork Regular Maxirapid CHO | |
| Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
| Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, Umuline Rapide Umuline Regular, Winthrop Rapid Humulin ReliOn R | |
| R-DNA | ReliOn/Novolin R (No longer produced.) |
References[]
- ↑ Insulins. North American Veterinary Conference Clinicians Brief (2006).
- ↑ Prescribing Novo Insulins.
- ↑ Scientific Discussion-Actrapid. EMEA.
- ↑ Patient Information Leaflet-Actrapid. Novo Nordisk.
- ↑ Novo discontinuation notice for pens. Novo Nordisk.
- ↑ Novolin R cartridge Discontinuation Notice. US Food and Drug Administration.
- ↑ Humulin R patient leaflet. Eli Lilly.
- ↑ Humulin R Regular Human Insulin. Revolution Health.
- ↑ Patient Information Leaflet-Humulin S. Eli Lilly.
- ↑ Humulin S Prescribing Information.
- ↑ Lilly EU/UK Product Information Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Prescribing Insuman Insulins.
- ↑ Patient Information Leaflet-Insuman Rapid. Sanofi-Aventis.
- ↑ DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ DeRuiter, Jack. Insulin Preparations-Lente. Auburn University.
- ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
Note--in 1980, there were no r-DNA/GE/GM insulins - ↑ Resource Guide 2005-American Diabetes Association
- ↑ DeRuiter, Jack. Insulin Preparations-Lente Insulin. Auburn University.
More Information[]
- NACDS-Insulin Chart-Page 2
- Leeds NHS UK Insulin Guide
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of regular/neutral/normal insulins.
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