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Novolin 70/30
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Novolin
Also known as Actraphane 30/70, Mixtard 30, Novolin 30R, Penmix 30[1], ReliOn/Novolin 70/30
Similar to  


Names of Lilly r-DNA/GE/GM insulins worldwide

Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 24 months
When opened 28 days room temp.
In pen 28 days room temp.
Notes  
NVN18370 73077 5

Novolin Mixed 70/30 insulin-30% R/Neutral and 70% NPH/isophane.

This is the Novo Nordisk brand name for one of the mixed 30% R/neutral, 70% NPH/isophane crystal insulin it sells in North America; the other is ReliOn/Novolin 70/30

The same insulin made by the same company is called Mixtard 30[2][3] and Actraphane 30/70[4][5] once you cross the Atlantic.

Other comparable insulins made by other companies are: Humulin M3[6][7][8], Humulin 70/30[9], Umuline Profil 30, Huminsulin Profil III, Humulina 30/70, Humuline 30/70, Insuman Comb 30 and Winthrop Comb 30.

As of January 1, 2010, Novo has discontinued offering Novolin 70/30 in cartridges for refillable insulin pens[10][11].

Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.

For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.

The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:


Non-Analog Mixed Insulins
Intermediate acting All Intermediate-acting

References


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