Novolin 70/30 | |
R/Neutral/NPH/Isophane Mix by Novo Nordisk | |
intermediate-acting | r-DNA/GE/GM |
U100 | isophane |
Line | Novolin |
Also known as | Actraphane 30/70, Mixtard 30, Novolin 30R, Penmix 30[1], ReliOn/Novolin 70/30 |
Similar to | |
Action in dogs |
|
Use and Handling | |
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Type | cloudy |
Shelf Life | 24 months |
When opened | 28 days room temp. |
In pen | 28 days room temp. |
Notes |
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This is the Novo Nordisk brand name for one of the mixed 30% R/neutral, 70% NPH/isophane crystal insulin it sells in North America; the other is ReliOn/Novolin 70/30
The same insulin made by the same company is called Mixtard 30[2][3] and Actraphane 30/70[4][5] once you cross the Atlantic.
Other comparable insulins made by other companies are: Humulin M3[6][7][8], Humulin 70/30[9], Umuline Profil 30, Huminsulin Profil III, Humulina 30/70, Humuline 30/70, Insuman Comb 30 and Winthrop Comb 30.
As of January 1, 2010, Novo has discontinued offering Novolin 70/30 in cartridges for refillable insulin pens[10][11].
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
Non-Analog Mixed Insulins | ||
---|---|---|
All Intermediate-acting |
Expressed As | Expressed As | Insulin Is |
---|---|---|
10/90 | 90/10 | 10% R/Neutral Insulin 90% NPH/Isophane Insulin |
20/80 | 80/20 | 20% R/Neutral Insulin 80% NPH/Isophane Insulin |
30/70 | 70/30 | 30% R/Neutral Insulin 70% NPH/Isophane Insulin |
40/60 | 60/40 | 40% R/Neutral Insulin 60% NPH/Isophane Insulin |
50/50 | 50/50 | 50% R/Neutral Insulin 50% NPH/Isophane Insulin |
References
- ↑ Medsafe NZ Penmix 30
- ↑ Prescribing Novo Insulins
- ↑ Scientific Discussion-Mixtard. EMEA.
- ↑ Scientific Discussion-Actraphane. EMEA.
- ↑ Insulins & Mixtures
- ↑ Electronic Medicines Compendium (EMC) UK Patient Information Leaflet-Humulin M3
- ↑ Humulin M3 Prescribing Information
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles
- ↑ Humulin 70/30-NPH;R Human Insulin
- ↑ Novo discontinuation notice for pens
- ↑ Novolin 70/30 cartridge Discontinuation Notice