NovoMix 30

Another name for Novo Nordisk's 70% aspart protamine crystal ^[1] suspension and 30% aspart mixed, intermediate length insulin. ^[2]^[3]^[4]

Intermediate-acting Analogs
	All Non-soluble
Humalog 75/25 insulin Lispro
Humalog Mix 25 insulin Lispro
Humalog 50/50 insulin Lispro
Humalog Mix 50 insulin Lispro
Novolog Mix insulin Aspart
NovoMix 30 insulin Aspart

Analog Insulins: amino acid sequences[]

Amino Acid Sequence of Insulin Preparations ^[5]
Amino Acid Substitutions
	A-Chain Position			B-Chain Position
Source Species	A-8	A-10	A-21	B-28	B-29	B-30	B-31 B-32
Beef	Ala	Val	Asn	Pro	Lys	Ala	N/A
Pork	Thr	Ilc	Asn	Pro	Lys	Ala	N/A
Human	Thr	Ilc	Asn	Pro	Lys	Thr	N/A
Aspart	Thr	Ilc	Asn	Aspartic Acid	Lys	Thr	N/A
Lispro	Thr	Ilc	Asn	Lys	Pro	Thr	N/A
Glulisine	Thr	Ilc	Asn	Pro	Glu	Thr	N/A
Lantus (glargine)	Thr	Ilc	Gly	Pro	Lys	Thr	Arg
Levemir(detemir)	Thr	Ilc	Asn	Pro	Lys	N/A	Myristic Acid
Ala=Alanine Val=Valine Asn=Asparagine Pro-Proline Lys=Lysine Thr=Threonine Ilc=Isoleucine Glu-Glutamine Gly=Glycine

Pharmacokinetics of Insulin Preparations ^[5]
Insulin Preparations	Onset (hr)	Peak (hr)	Duration (hr)
Rapid-Acting
R/Neutral	0.5 to 1	2.5 to 5	8 to 12
Lispro (Humalog)	0.25 to 0.5	0.5 to 1.5	2 to 5
Aspart (Novolog)	0.17 to 0.33	1 to 3	3 to 5
Glulisine (Apidra)	0.17 to 0.33	1 to 3	3 to 5
Intermediate-Acting
NPH Isophane	1 to 1.5	6 to 14	16 to 24
Lente ^[6]	1 to 3	6 to 14	20+
70/30-30/70	0.5 to 1	2 to 12	24
50/50	0.5 to 1	2 to 12	24
Novolog 70/30 Mix	0.25	1 to 3	24
Humalog 75/25 Mix	0.25	0.5 to 1.5	24
Long-Acting
Ultralente ^[6]	6	14 to 18	18 to 24
PZI ^[7]	4 to 6	14 to 18	24 to 36
Glargine (Lantus)	1.1	N/A	24
Detemir (Levemir)	0.8 to 2	N/A	24

These are human activity profiles.