Canine Diabetes Wiki
Maxirapid CHO
R, Neutral by Polfa Tarchomin
U80 none
Action in dogs:
  • onset 30-60 minutes,
  • peak 2-4h,
  • duration 6-8h
Also known as: Pork R, pork neutral
Similar to: Betasint Porcine Corriente
Hypurin Porcine Neutral,[1] Hypurin Pork Regular
Iletin II R, Leo Neutral, Pork Actrapid [2]
Use and Handling:
Shelf Life: 36 months Type: soluble, clear
When Opened: 6 weeks room temp.
In Pen: 6 weeks room temp.
Notes: Protect from light and heat
Do Not Freeze,
Cartridges in use are not to be refrigerated
May be used intravenously
May be used intramuscularly
Insulinum Maxrapid 400px

Maxirapid CHO pork Regular/Normal/Neutral insulin by Polfa Tarchomin.

Maxirapid CHO [3][4] is a short-acting, pork-based insulin made by Polfa Tarchomin. [5] Betasint Porcine Corriente is similar, as is CP Pharma's [6] Hypurin Porcine Neutral/Hypurin Pork Regular.

Eli Lilly's Iletin II R [7] was comparable, as was Novo Nordisk's Pork Actrapid. [8][9][10][11] which was discontinued at the end of December 2007 [12]

As with all R/neutral insulins, regardless of species, nothing has been added to alter the speed or action of the insulin. [13][14]

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [15] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [16]

The very small insulin particles in semilente insulin are suspended by zinc. [15] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [17][18] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [15]

R/Neutral Insulins[]


  1. Response to Withdrawal of Novo Porcine Insulin Range. CP/Wockhardt UK.
  2. Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  3. Maxirapid CHO. Polfa Tarchomin.
  4. Google Translated page for Maxirapid CHO. Polfa Tarchomin.
  5. About Polfa Tarchomin. Polfa Tarchomin.
  6. Hypurin Porcine Neutral. Wockhardt UK.
  7. Iletin II R Discontinuation Notice. US Food and Drug Administration (July 2005).
  8. Pork Actrapid Patient Information. Net
  9. Patient Information Leaflet-Pork Actrapid. Novo Nordisk.
  10. Prescribing Porcine Insulin.
  11. Prescribing Novo Animal Insulin.
  12. Pork Actrapid Discontinuation Notice. Novo Nordisk.
  13. Hypurin Porcine Neutral Patient Information. Net
  14. Humulin R patient leaflet. Eli Lilly.
  15. 15.0 15.1 15.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content
  16. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  17. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  18. Resource Guide 2005-American Diabetes Association

More Information[]

Related pages
Hypurin pork r
Pork Actrapid
Betasint Porcine Corriente
Hypurin Porcine Neutral
Pork Actrapid
Iletin II R