Leo Neutral [1]
R, Neutral by Nordisk
U40, U100 none
Action in dogs:
  • onset 30-60 minutes,
  • peak 2-4h,
  • duration 6-8h
Line: Nordisk
Also known as: Pork Actrapid, Pork R, pork neutral
Similar to: Betasint Porcine Corriente
Hypurin Porcine Neutral, [2] Hypurin Pork Regular
Maxirapid CHO, Iletin II R
Use and Handling:
Shelf Life: 36 months Type: soluble, clear
When Opened: 6 weeks room temp.
In Pen: N/A
Notes: Protect from light and heat
Do Not Freeze,
May be used intravenously
May be used intramuscularly
Human Activity Profiles Various Insulins

Time activity profile for Pork Actrapid.

Note that some countries have the brand name in U40 strength.

A short-acting, soluble R/neutral pork insulin which was made by Nordisk. [1][3][4]

Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed .[5]

It is comparable to Iletin II R, [6] formerly made by Eli Lilly, Hypurin Porcine Neutral/Hypurin Pork Regular by CP Pharma, [7][8][9][10] Betasint Porcine Corriente by Beta Laboratorios and Maxirapid CHO by Polfa Tarchomin.

Novo Nordisk no longer offered Pork Actrapid after December 2007[11][12][13][14][15] according to the Novo Nordisk Australasia Home Page, [16] it was discontinued there by December, 2006. It's now necessary to use Hypurin Porcine Neutral from CP Pharma. [17]

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [18] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [19]

The very small insulin particles in semilente insulin are suspended by zinc. [18] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [20][21] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [18]

R/Neutral InsulinsEdit


More InformationEdit

Related pages
Hypurin pork r
Pork Actrapid
Betasint Porcine Corriente
Hypurin Porcine Neutral
Pork Actrapid
Maxirapid CHO
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