| Isuhuman Comb 25 | |
| R/Neutral/NPH/Isophane Mix by Aventis | |
| intermediate-acting | r-DNA/GE/GM |
| U40, U100 | isophane |
| Line | Insuman |
| Also known as | Winthrop Comb 25, Insuman Comb 25 |
| Similar to | |
| Action in dogs |
|
| Use and Handling | |
|---|---|
| Type | cloudy |
| Shelf Life | 24 months |
| When opened | 4 weeks room temp. |
| In pen | 4 weeks room temp. |
| Notes |
|
Time activity profile for Insuman Comb 25.
|
Note that some countries have the brand name in U40 strength. | ||
This 75% NPH/isophane crystal[1] and 25% R/neutral insulin mix[2][3] is intermediate-acting and made by Aventis as part of its Insuman line of products[4].
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70[5]. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
| Non-Analog Mixed Insulins | ||
|---|---|---|
|
All Intermediate-acting | |
| Expressed As | Expressed As | Insulin Is |
|---|---|---|
| 10/90 | 90/10 | 10% R/Neutral Insulin 90% NPH/Isophane Insulin |
| 20/80 | 80/20 | 20% R/Neutral Insulin 80% NPH/Isophane Insulin |
| 30/70 | 70/30 | 30% R/Neutral Insulin 70% NPH/Isophane Insulin |
| 40/60 | 60/40 | 40% R/Neutral Insulin 60% NPH/Isophane Insulin |
| 50/50 | 50/50 | 50% R/Neutral Insulin 50% NPH/Isophane Insulin |
References