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{|class="wikitable" align="right" width="300" bgcolor="powderblue"|
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{{Insulin|
  
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! colspan="2" style="background:#cae1ff; width:300px;font-size:10pt" | Isuhuman Comb 25
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bgcolor=#cae1ff|
  
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|-
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fgcolor=#000080|
  
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| colspan="2" style="background:aliceblue; width:300px; text-align:center;font-size:9pt" |[[Mixed insulins|R/Neutral/NPH/Isophane Mix]] by [[Aventis]]
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name=Isuhuman Comb 25|
  
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|-
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generic=[[Mixed insulins|R/Neutral/NPH/Isophane Mix]]|
  
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|colspan="2" style="background:#bcd2ee; width:300px; text-align:center;font-size:9pt"|[[intermediate-acting]]
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mfg=[[Aventis]]|
  
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|-
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|- align="center" style="background:#cae1ff;border-bottom:3px solid grey;"|
  
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| colspan="2" style="background:#bcd2ee; width:300px; text-align:center;font-size:9pt"|[[r-DNA/GE/GM]]
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action=[[intermediate-acting]]|
  
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|-
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origin=[[r-DNA/GE/GM]]|
  
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! colspan="1" style="background:#bcd2ee; width:150px; text-align:center;font-size:9pt" | U40, U100
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strength=U40, U100|
  
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|colspan="1" style="background:#bcd2ee; width:150px;text-align:center;font-size:9pt"|[[isophane]]
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suspension=[[isophane]]|
  
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|-
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line=[[Insuman]]|
  
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|colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Action in dogs:'''
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aliases=[[Winthrop Comb 25]],<br> [[Insuman Comb 25]]|
  
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similar=&nbsp;|
  
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dogaction=&nbsp;
  
 
*onset 0.5-3h,
 
*onset 0.5-3h,
 
*peak 2-10h,
 
*peak 2-10h,
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*duration 4-24h|
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*duration 4-24h
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|-
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cloudyorsoluble=[[cloudy]]|
  
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| colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Line:''' [[Insuman]]
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shelflife= 24 months|
  
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|-
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openedlife= 4 weeks room temp.|
  
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| colspan="2" style="background:aliceblue; width:300px; font-size:9pt;text-align:left"| '''Also known as:''' [[Insuman Comb 25]]<br>[[Insuhuman Comb 25]],&nbsp;[[Winthrop Comb 25]]
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penlife= 4 weeks room temp.|
  
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|-
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handlingnotes=&nbsp;
  
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| colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''Similar to:''' N/A<br><br>[http://images3.wikia.nocookie.net/__cb20100602042136/diabetesindogs/images/2/23/WW_Humuline.pdf Names of Lilly r-DNA/GE/GM insulins worldwide]
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*protect from light and heat
  
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|-
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*Do Not Freeze
  
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| colspan="2" style="background:#cae1ff; width:300px;text-align:center;font-size:9pt" | '''Use and Handling:'''
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*Do not use if product does not [[re-suspend]]
  
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|-
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*[[Rolling insulin|Roll]]
  
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| colspan="1" style="background:aliceblue; width:150px;font-size:9pt;text-align:left"| '''Shelf Life:''' 24 months
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*Do not use [[intravenously]]
  
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|colspan="1" style="background:aliceblue; width:150px;font-size:9pt;text-align:left" | '''Type:''' [[cloudy]]
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*Do not refrigerate in use pens/cartridges.
  
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|-
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}}
  
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|colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''When Opened:''' 4 weeks room temp.
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|-
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|colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''In Pen:''' 4 weeks room temp.
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|-
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|colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''Notes:''' Protect from light and heat<br> Do Not Freeze, [[Resuspending insulin|Resuspend]]<br> Do not use if product does not [[re-suspend]]<br>Do not use [[intravenously]]
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|}
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[[Image:Wp_comb25_1.GIF|thumb|left|300px|Time activity profile for Insuman Comb 25.]]<br clear=left>
  
[[Image:Wp_comb25_1.GIF|thumb|left|300px|Time activity profile for Insuman Comb 25.]]<br clear=left>
 
{|
  
{|
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|style="height:1px;border:0;" colspan="3"|
 
|style="height:1px;border:0;" colspan="3"|
 
|-valign="top"
  
|-valign="top"
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|style="padding:5px;border:2px solid #b9f1f0;background-color:#f0f8ff;" width="50%"|
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|style="padding:5px;border:2px solid #b9f1f0;background-color:#f0f8ff;" width="100%"|
 
'''Note that some countries have the brand name in U40 strength.'''
  
'''Note that some countries have the brand name in U40 strength.'''
 
|}
  
|}
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This 75% NPH/isophane crystal<ref> {{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000428/WC500029819.pdf|title=Scientific Discussion-Mixtard|publisher=EMEA}}</ref> and 25% R/neutral insulin mix<ref>{{cite web|url=http://images2.wikia.nocookie.net/diabetesindogs/images/7/7f/Insuman_Comb_25_patient_info_leaflet.pdf |title=Patient Information Leaflet-Insuman Comb 25|publisher=Sanofi-Aventis}}</ref><ref>{{cite web|url=http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Insuman_insulins.htm |title=Insuman Prescribing Information}}</ref> is intermediate-acting and made by [[Aventis]] as part of its Insuman line of products.<ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/A11456_Range_Poster.pdf|title= Aventis Poster-Insuman & Lantus Insulins|publisher=Sanofi-Aventis}}</ref><ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000201/WC500033779.pdf|title=Scientific Discussion-Insuman|publisher=EMEA}}</ref>
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This 75% NPH/isophane crystal <ref> {{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000428/WC500029819.pdf|title=Scientific Discussion-Mixtard|publisher=EMEA}}</ref> and 25% R/neutral insulin mix <ref>{{cite web|url=http://images2.wikia.nocookie.net/diabetesindogs/images/7/7f/Insuman_Comb_25_patient_info_leaflet.pdf |title=Patient Information Leaflet-Insuman Comb 25|publisher=Sanofi-Aventis}}</ref><ref>{{cite web|url=http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Insuman_insulins.htm |title=Insuman Prescribing Information}}</ref> is intermediate-acting and made by [[Aventis]] as part of its Insuman line of products. <ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/A11456_Range_Poster.pdf|title= Aventis Poster-Insuman & Lantus Insulins|publisher=Sanofi-Aventis}}</ref><ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000201/WC500033779.pdf|title=Scientific Discussion-Insuman|publisher=EMEA}}</ref>
   
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[[Mixed insulins]] cover a wide range as they can be [[:Category:Origin|animal]] origin, [[r-DNA/GE/GM]] origin or [[analog]] insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
 +
[[Mixed insulins]] cover a wide range as they can be [[:Category:Origin|animal]] origin, [[r-DNA/GE/GM]] origin or [[analog]] insulins. The non-analog mixed insulins are made up of [[:Category:Intermediate-acting|intermediate-acting]] [[NPH]]/isophane insulin and [[:Category:Short-acting|short-acting]] [[R]]/neutral. normal insulin. The analog mixes are made from [[:Category:Intermediate-acting|intermediate-acting]] protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and [[:Category:Fast-acting|fast-acting]] analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
   
 
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
  
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
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The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork [[Iletin]] and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
  
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork [[Iletin]] and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
   
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{| align="center" width="500" border="1" bgcolor="powderblue"|
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{| class="collapsible collapsed" align="center" width="500" border="1" bgcolor="powderblue"|
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! bgcolor="#BCD2EE" colspan="3" |Non-Analog Mixed Insulins
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! bgcolor="BCD2EE" colspan="3" |Non-Analog Mixed Insulins
 
|-
  
|-
 
! bgcolor="lightcyan" width="200" |[[Image:Intermediate_acting.jpg|200px]]
  
! bgcolor="lightcyan" width="200" |[[Image:Intermediate_acting.jpg|200px]]
 
! bgcolor="#cae1ff" colspan="2" |All [[Intermediate-acting]]
  
! bgcolor="#cae1ff" colspan="2" |All [[Intermediate-acting]]
−
|}
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|-
  ⚫
! colspan="1" bgcolor="aliceblue"|Insulin Is
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{|class="collapsible collapsed" align="center" width="500" border="1" bgcolor="powderblue"|
  
 
! colspan="1" bgcolor="aliceblue"| Expressed As
  
! colspan="1" bgcolor="aliceblue"| Expressed As
 
!colspan="1" bgcolor="aliceblue"|Expressed As
  
!colspan="1" bgcolor="aliceblue"|Expressed As
⚫
! colspan="1" bgcolor="aliceblue"|Insulin Is
  
 
|-
  
|-
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! colspan="1" bgcolor="ivory"|10/90
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! colspan="1" bgcolor="ivory"|10% [[R|R/Neutral Insulin]]<br />90% [[NPH|NPH/Isophane Insulin]]
 
!colspan="1" bgcolor="ivory"|90/10
  
!colspan="1" bgcolor="ivory"|90/10
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! colspan="1" bgcolor="ivory"|10% [[R|R/Neutral Insulin]]<br />90% [[NPH|NPH/Isophane Insulin]]
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! colspan="1" bgcolor="ivory"|10/90
 
|-
  
|-
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! colspan="1" bgcolor="ivory"|20/80
  
⚫
!colspan="1" bgcolor="ivory"|80/20
  
 
! colspan="1" bgcolor="ivory"|20% [[R|R/Neutral Insulin]]<br />80% [[NPH|NPH/Isophane Insulin]]
  
! colspan="1" bgcolor="ivory"|20% [[R|R/Neutral Insulin]]<br />80% [[NPH|NPH/Isophane Insulin]]
  ⚫
!colspan="1" bgcolor="ivory"|80/20
  ⚫
! colspan="1" bgcolor="ivory"|20/80
 
|-
  
|-
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! colspan="1" bgcolor="ivory"|30/70
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! colspan="1" bgcolor="ivory"|30% [[R|R/Neutral Insulin]]<br />80% [[NPH|NPH/Isophane Insulin]]
 
!colspan="1" bgcolor="ivory"|70/30
  
!colspan="1" bgcolor="ivory"|70/30
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! colspan="1" bgcolor="ivory"|30% [[R|R/Neutral Insulin]]<br />70% [[NPH|NPH/Isophane Insulin]]
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! colspan="1" bgcolor="ivory"|30/70
 
|-
  
|-
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! colspan="1" bgcolor="ivory"|40/60
  
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! colspan="1" bgcolor="ivory"|60/40
  
 
! colspan="1" bgcolor="ivory"|40% [[R|R/Neutral Insulin]]<br />60% [[NPH|NPH/Isophane Insulin]]
  
! colspan="1" bgcolor="ivory"|40% [[R|R/Neutral Insulin]]<br />60% [[NPH|NPH/Isophane Insulin]]
  ⚫
! colspan="1" bgcolor="ivory"|60/40
  ⚫
! colspan="1" bgcolor="ivory"|40/60
 
|-
  
|-
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! colspan="1" bgcolor="ivory"|50/50
  
⚫
!colspan="1" bgcolor="ivory"|50/50
  
 
! colspan="1" bgcolor="ivory"|50% [[R|R/Neutral Insulin]]<br />50% [[NPH|NPH/Isophane Insulin]]
  
! colspan="1" bgcolor="ivory"|50% [[R|R/Neutral Insulin]]<br />50% [[NPH|NPH/Isophane Insulin]]
  ⚫
!colspan="1" bgcolor="ivory"|50/50
  ⚫
! colspan="1" bgcolor="ivory"|50/50
 
|}
  
|}
   
 
==References==
  
==References==
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{{Reflist|colwidth=30em}}
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<references/>
  
−  
   
 
==More Information==
  
==More Information==
   
−
*[http://www.yorkshirediabetes.com/downloads/A11456_Range_Poster.pdf Yorkshire Diabetes-Chart of Insuman Insulin Ranges]
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*[http://www.yorkshirediabetes.com/downloads/A11456_Range_Poster.pdf Chart of Insuman Insulin Ranges] Yorkshire Diabetes
  +
  +
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<center>'''Related pages'''</center>
  +
{|align="center" width="300"
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  +
|<center>[[Image:Wp comb25 1.GIF|100px]]</center>
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  +
|<center>[[Image:Wp comb25 1.GIF|100px]]</center>
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|-
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|<center>[[Insuman Comb 25]]</center>
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|<center>[[Winthrop Comb 25]]</center>
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|}
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[[Category:25-75]]
 
[[Category:Conditions]]
  
[[Category:Conditions]]
 
[[Category:Insulins]]
  
[[Category:Insulins]]
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[[Category:Aventis]]
  
[[Category:Aventis]]
 
[[Category:Insuman]]
  
[[Category:Insuman]]
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[[Category:Currently marketed insulins]]

Latest revision as of 23:23, 23 May 2012

Isuhuman Comb 25
R/Neutral/NPH/Isophane Mix by Aventis
intermediate-acting
r-DNA/GE/GM
U40, U100 isophane
Action in dogs:
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Line: Insuman
Also known as: Insuman Comb 25
Insuhuman Comb 25, Winthrop Comb 25
Similar to: N/A

Names of Lilly r-DNA/GE/GM insulins worldwide
Use and Handling:
Shelf Life: 24 months Type: cloudy
When Opened: 4 weeks room temp.
In Pen: 4 weeks room temp.
Notes: Protect from light and heat
Do Not Freeze, Resuspend
Do not use if product does not re-suspend
Do not use intravenously
Wp comb25 1

Time activity profile for Insuman Comb 25.


Note that some countries have the brand name in U40 strength.

This 75% NPH/isophane crystal [1] and 25% R/neutral insulin mix [2][3] is intermediate-acting and made by Aventis as part of its Insuman line of products. [4][5]

Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.

For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.

The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:

References[]

  1. ↑ Scientific Discussion-Mixtard. EMEA.
  2. ↑ Patient Information Leaflet-Insuman Comb 25. Sanofi-Aventis.
  3. ↑ Insuman Prescribing Information.
  4. ↑ Aventis Poster-Insuman & Lantus Insulins. Sanofi-Aventis.
  5. ↑ Scientific Discussion-Insuman. EMEA.

More Information[]


Related pages
Wp comb25 1
Wp comb25 1
Insuman Comb 25
Winthrop Comb 25
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