Changes: Isuhuman Comb 25

Revision as of 18:41, 26 May 2010

Use and Handling
Isuhuman Comb 25
R/Neutral/NPH/Isophane Mix by Aventis
intermediate-acting	r-DNA/GE/GM
U100	isophane
Line	Insuman
Also known as	Winthrop Comb 25, Insuman Comb 25
Similar to
Action in dogs	onset 0.5-3h, peak 2-10h, duration 4-24h
Type	cloudy
Shelf Life	24 months
When opened	4 weeks room temp.
In pen	4 weeks room temp.
Notes	protect from light and heat Do Not Freeze Do not use if product does not re-suspend Roll Do not use intravenously Do not refrigerate in use pens/cartridges.

Time activity profile for Insuman Comb 25.

This 75% NPH/isophane crystal^[1] and 25% R/neutral insulin mix^[2]^[3] is intermediate-acting and made by Aventis as part of its Insuman line of products^[4].

Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.

For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70^[5]. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.

The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:

Non-Analog Mixed Insulins
	All Intermediate-acting

Expressed As	Expressed As	Insulin Is
10/90	90/10	10% R/Neutral Insulin 90% NPH/Isophane Insulin
20/80	80/20	20% R/Neutral Insulin 80% NPH/Isophane Insulin
30/70	70/30	30% R/Neutral Insulin 70% NPH/Isophane Insulin
40/60	60/40	40% R/Neutral Insulin 60% NPH/Isophane Insulin
50/50	50/50	50% R/Neutral Insulin 50% NPH/Isophane Insulin

References

More Information

Yorkshire Diabetes-Chart of Insuman Insulin Ranges

[1] EMEA Scientific Discussion-Mixtard

[2] Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Comb 25

[3] Insuman Prescribing Information

[4] Aventis Poster-Insuman & Lantus Insulins

[5] Humulin 10/90-NPH;R Human Insulin Remedyfind.com

[1]

[2]

[3]

[4]

[5]

@@ Line 29: / Line 29: @@
 *Do not refrigerate in use pens/cartridges.
 }}
-[[Image:Wp_comb25_1.GIF|thumb|left|300px|Time activity profile for Insuman Comb 25.]]This 75% NPH/isophane crystal<ref> [http://www.emea.europa.eu/humandocs/PDFs/EPAR/mixtard/226802en6.pdf EMEA Scientific Discussion-Mixtard]</ref> and 25% R/neutral insulin mix<ref>[http://images2.wikia.nocookie.net/diabetesindogs/images/7/7f/Insuman_Comb_25_patient_info_leaflet.pdf Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Comb 25]</ref><ref>[http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Insuman_insulins.htm Insuman Prescribing Information]</ref> is intermediate-acting and made by [[Aventis]] as part of its Insuman line of products<ref>[http://www.yorkshirediabetes.com/downloads/A11456_Range_Poster.pdf Aventis Poster-Insuman & Lantus Insulins]</ref>.
+[[Image:Wp_comb25_1.GIF|thumb|left|300px|Time activity profile for Insuman Comb 25.]]<br clear=left>This 75% NPH/isophane crystal<ref> [http://www.emea.europa.eu/humandocs/PDFs/EPAR/mixtard/226802en6.pdf EMEA Scientific Discussion-Mixtard]</ref> and 25% R/neutral insulin mix<ref>[http://images2.wikia.nocookie.net/diabetesindogs/images/7/7f/Insuman_Comb_25_patient_info_leaflet.pdf Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Comb 25]</ref><ref>[http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Insuman_insulins.htm Insuman Prescribing Information]</ref> is intermediate-acting and made by [[Aventis]] as part of its Insuman line of products<ref>[http://www.yorkshirediabetes.com/downloads/A11456_Range_Poster.pdf Aventis Poster-Insuman & Lantus Insulins]</ref>.
 [[Mixed insulins]] cover a wide range as they can be [[:Category:Origin|animal]] origin, [[r-DNA/GE/GM]] origin or [[analog]] insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.