Canine Diabetes Wiki
Insuvet Protamine Zinc
PZI by Pfizer Animal Health
U100 protamine
Action in dogs:
  • onset 8-20h,
  • peak Xh,
  • duration Xh rarely used [1][2]
Line: Insuvet
Also known as: Beef PZI
Similar to: Hypurin Bovine Protamine Zinc, VOPA PZI, Summit PZI, Hypurin Vet Protamine Zinc, BCP PZI
Use and Handling:
Shelf Life: 36 months Type: cloudy
When Opened: 28 days room temp.
In Pen: N/A
Notes: Protect from light and heat
Do Not Freeze, store at 2-8C, Resuspend
Do not use if product does not re-suspend 
Do not use intravenously [3]
Intramuscular use is not advised
Do not mix Protamine Zinc insulin in the same syringe with R/Neutral insulin

All Insuvet insulins have been discontinued by Pfizer Animal Health.[4][5] The insulins were made under contract by Wockhardt UK for both Pfizer and for Schering-Plough Animal Health, who owned the brand name earlier. Wockhardt makes the same insulins under their Hypurin brand name.[6]

Switching from Insuvet to Caninsulin

91 main

Insuvet Lente-U100 Bovine Protamine Zinc insulin.

One of the products in the Insuvet [10] product line, this is a pure bovine U100 Protamine Zinc insulin (PZI), [11][12][13] for veterinary use and was available in the UK only from veterinary clinics. [14]

Comparing Insuvet insulins with Hypurin insulins[]

Currently marketed Wockhardt Bovine insulins comparable with Insuvet insulins:

Hypurin Bovine Neutral [15] EMC UK product description.[16]

Insuvet Neutral VMD product description [17]

Hypurin Bovine Lente [18] EMC product description.[19]

Insuvet Lente VMD product description [20]

Hypurin Bovine Protamine Zinc [9] EMC UK product description.[21]

Insuvet Protamine Zinc VMD product description[22]

If you are in Canada, your vet may also be able to obtain manufactured beef insulin from the UK for you through Health Canada's Emergency Drug Release program. [23] With it, you are able to receive up to 6 months worth of insulin; a C$ 50.00 fee for the application is required. [24] If permitted, you would then be eligible to import PZI insulins such as Hypurin Bovine Protamine Zinc, as well as other bovine or porcine insulins.

The program is similar to Health Canada's Special Access Programme [25] for importing necessary drugs for people.

Wherever you are, the comparable CP Pharma Hypurin insulins should be able to be imported provided you follow the import rules and guidelines for your country of residence. CP Pharma will be glad to assist you if you contact them through their website link on the CP Pharma page.

Recently the US-FDA has dropped their paperwork requirements regarding the importation of non-US approved drugs for animal patients who need them. [26] While 100% bovine protamine zinc insulin is available in the US through compounding pharmacies, there is no source of bovine R/Neutral or bovine Lente. It would appear that the relaxed restrictions would make it easier and quicker for a veterinarian to obtain bovine insulins for a diabetic patient.

Technical details[]

NOAH Compendium-UK [27] officially describes it as highly purified bovine protamine zinc (PZI) insulin, according to British Pharmacopeia (BP) standards and definitions. It is U100 strength and presented in 10ml vials. It is described [28] as being a medium to long lasting insulin, with onset from 2-5 hours after injection, peak at 12-24 hours, and maximum duration of 24-36 hours.

NOAH goes on to say that onset, peak and duration times have been reported as being variable in dogs.

PZI contains more zinc and protamine than NPH/isophane insulin and it is primarily the extra protamine which gives it its long-acting duration.[29] The additional protamine in the suspension [30] must first be broken down by proteolytic enzymes AKA proteases, [31] before the insulin in PZI can be absorbed. NPH/isophane insulin contains less protamine than PZI does and because there's less, it is an intermediate-acting insulin.

Usage and handling[]

Long acting

All PZI's are long-acting insulins with activity profiles similar to this.

Dosage information [32] for Insuvet Protamine Zinc PZI.

This insulin [33] insulin is to be given subcutaneously only.

Store at [34]2-8C; do not freeze. Insuvet Protamine Zinc needs rolling. Product should not be used if it does not re-suspend. The vial has a life of 28 days after first use and a shelf life of 2 years [35].

Comparable insulins are: Hypurin Vet Protamine Zinc (also for veterinary use) and Hypurin Bovine Protamine Zinc [36], which is approved for human use. The latter is the only one which can be exported from the UK. The U100 strength of BCP PZI and Summit PZI is also comparable to this insulin.

Insuvet PZI comes in a 10ML vial. It should be kept refrigerated and rolled gently several times before use to insure it is well-mixed and shows a uniform milky consistency.

No Combining For PZI

Protamine Zinc PZI [37] insulin cannot be combined with other insulins, due to the amount of protamine in the insulin's formula. [38][39][40][41]


  1. Insulins. North American Veterinary Conference-Clinicians Brief (2005).
  2. Scott-Moncrieff, Catherine (2009). Canine and Feline Diabetes Mellitus I-page 4. Western Veterinary Conference.
  3. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  4. No Further Supplies of Insuvet Insulins. UK.
  5. Pfizer insulin products currently unavailable. VetsOnline UK.
  6. SPAH Contracts CP/Wockhardt UK for Insuvet Insulins. Wockhardt.
  7. Hypurin Bovine Neutral. Wockhardt UK.
  8. Hypurin Bovine Lente. Wockhardt UK.
  9. 9.0 9.1 Hypurin Bovine Protamine Zinc. Wockhardt UK.
  10. Inusvet Protamine Zinc. Veterinary Medicines Directorate UK.
  11. Hypurin Bovine Protamine Zinc Patient Information. Net
  12. Hypurin Bovine Protamine Zinc. Wockhardt UK.
  13. Definition of Protamine Zinc Insulin. Merck Manual.
  14. Pfizer Animal Health Adds Former Schering-Plough Products to European Portfolio. Farming UK (2008).
  15. Hypurin Bovine Neutral. Wockhardt UK.
  16. Hypurin Bovine Neutral. EMC UK.
  17. Insuvet Neutral. VMD UK.
  18. Hypurin Bovine Lente. Wockhardt UK.
  19. Hypurin Bovine Lente. EMC UK.
  20. Insuvet Lente. VMD UK.
  21. Hypurin Bovine Protamine Zinc. EMC UK.
  22. Insuvet Protamine Zinc. VMD UK.
  23. Health Canada-Veterinary: Emergency Drug Release Information. HealthCanada.
  24. Health Canada-Emergency Drug Release Form. HealthCanada.
  25. Health Canada-Special Access Programme. HealthCanada.
  26. FDA no longer issuing letters for importation of unapproved animal drugs. JAVMA News (15 October 2009).
  27. Insuvet. NOAH Compendium.
  28. Insuvet Uses. NOAH Compendium-UK.
  29. Greco, Deborah (2010). Treating Diabetes Mellitus in Dogs and Cats. Western Veterinary Conference.
  30. Williams, Robert (1968). PZI Insulin--More Protamine Than NPH/Isophane Insulin-Textbook of Endocrinology, 4th edition. W.B. Saunders.
  31. Proteolytic Enzymes. Wikipedia.
  32. Insuvet Dosage and Administration. NOAH Compendium-UK.
  33. Insuvet Contraindications/Warnings. NOAH Compendium-UK.
  34. Insuvet Pharmaceutical Information. NOAH Compendium-UK.
  35. Hypurin Protamine Zinc. Wockhardt UK.
  36. Prescribing Bovine Insulin.
  37. DeRuiter, Jack. Insulin Preparations-Excess Protamine in Protamine Zinc Insulin Formula. Auburn University.
  38. Harrower AD, Duncan LJ, Clarke BF. (1975). Comparison of Injection Techniques for Soluble and Protamine Zinc Insulins in Diabetes Mellitus. Practitioner.
  39. Protamine Zinc Insulin (PZI) Binds to Soluble Insulin in Same Syringe. NHS.
  40. Petsulin Protamine Zinc-Page 5-Incompatibilities. Dechra.
  41. Inject Protamine Zinc Insulin Separately-Excess Protamine. Merck Manual.

Related pages
Long acting
Cp wockhardt bovine insulins
Cp wockhardt bovine insulins
Pure Bovine PZI
Hypurin Bovine Protamine Zinc
Hypurin Vet Protamine Zinc