Canine Diabetes Wiki
Insuvet Neutral
R, Neutral by Pfizer Animal Health
U100 none
Action in dogs:
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h
Line: Insuvet
Also known as: Beef R, beef neutral
Similar to: Hypurin Bovine Neutral
Hypurin Vet Neutral, Betasint Bovine Corriente
Iletin R
Use and Handling:
Shelf Life: 36 months Type: soluble, clear
When Opened: 28 days room temp.
In Pen: N/A
Notes: Protect from light and heat
Do Not Freeze,
May be used intravenously
Store between 2-8C

All Insuvet insulins have been discontinued by Pfizer Animal Health.[1][2] The insulins were made under contract by Wockhardt UK for both Pfizer and for Schering-Plough Animal Health, who owned the brand name earlier. Wockhardt makes the same insulins under their Hypurin brand name.[3]

Switching from Insuvet to Caninsulin

89 main

Insuvet Neutral--U100 bovine R/Neutral fast-acting insulin.

This is Pfizer Animal Health's U100 100% bovine R/neutral insulin [7][8] in the Insuvet product line. [9]

Comparing Insuvet insulins with Hypurin insulins[]

Currently marketed Wockhardt Bovine insulins comparable with Insuvet insulins:

Hypurin Bovine Neutral [4] EMC UK product description.[10]

Insuvet Neutral VMD product description [11]

Hypurin Bovine Lente [12] EMC product description.[13]

Insuvet Lente VMD product description [14]

Hypurin Bovine Protamine Zinc [15] EMC UK product description.[16]

Insuvet Protamine Zinc VMD product description[17]

If you are in Canada, your vet may also be able to obtain manufactured beef insulin from the UK for you through Health Canada's Emergency Drug Release program. [18] With it, you are able to receive up to 6 months worth of insulin; a C$ 50.00 fee for the application is required. [19] If permitted, you would then be eligible to import PZI insulins such as Hypurin Bovine Protamine Zinc, as well as other bovine or porcine insulins.

The program is similar to Health Canada's Special Access Programme [20] for importing necessary drugs for people.

Wherever you are, the comparable CP Pharma Hypurin insulins should be able to be imported provided you follow the import rules and guidelines for your country of residence. CP Pharma will be glad to assist you if you contact them through their website link on the CP Pharma page.

Recently the US-FDA has dropped their paperwork requirements regarding the importation of non-US approved drugs for animal patients who need them. [21] While 100% bovine protamine zinc insulin is available in the US through compounding pharmacies, there is no source of bovine R/Neutral or bovine Lente. It would appear that the relaxed restrictions would make it easier and quicker for a veterinarian to obtain bovine insulins for a diabetic patient.

Technical details[]

NOAH [22] is the UK's veterinary medicines compendium. Their entry for Insuvet neutral describes it as U100 highly purified bovine neutral  insulin injection BP (British Pharmacopia) presented in 10ml vials. Shelf life [23] of Insuvet Neutral is 3 years.

Usage and handling[]

It is described as having a rapid onset [24] and short activity duration. [25][26] Like all other R/neutral insulins, it has had nothing added to change its speed or length of activity. Since it is soluble, it is able to be administered intravenously, intramuscularly or subcutaneously. [27]

Store the insulin at [28] 2C-8C. Do not freeze. Insulin should only be in use 28 days before replacement.

Dosage information [29] for using Insuvet Neutral in ketoacidosis.

Comparable to CP Pharma's Hypurin Vet Neutral (veterinary use only) and Hypurin Bovine Neutral (approved for humans). It is available only in the UK. The insulin is also comparable to Beta Laboratorios' Betasint Bovine Corriente and the former Lilly insulin, Iletin I R.

R/Neutral Insulins[]


  1. No Further Supplies of Insuvet Insulins. UK.
  2. Pfizer insulin products currently unavailable. VetsOnline UK.
  3. SPAH Contracts CP/Wockhardt UK for Insuvet Insulins. Wockhardt.
  4. 4.0 4.1 Hypurin Bovine Neutral. Wockhardt UK. Cite error: Invalid <ref> tag; name "Neutral" defined multiple times with different content
  5. Hypurin Bovine Lente. Wockhardt UK.
  6. Hypurin Bovine Protamine Zinc. Wockhardt UK.
  7. Hypurin Bovine Neutral. Wockhardt UK.
  8. Insuvet Neutral. Veterinary Medicines Directorate UK.
  9. Pfizer Animal Health Adds Former Schering-Plough Products to European Portfolio. Farming UK (2008).
  10. Hypurin Bovine Neutral. EMC UK.
  11. Insuvet Neutral. VMD UK.
  12. Hypurin Bovine Lente. Wockhardt UK.
  13. Hypurin Bovine Lente. EMC UK.
  14. Insuvet Lente. VMD UK.
  15. Hypurin Bovine Protamine Zinc. Wockhardt UK.
  16. Hypurin Bovine Protamine Zinc. EMC UK.
  17. Insuvet Protamine Zinc. VMD UK.
  18. Health Canada-Veterinary: Emergency Drug Release Information. HealthCanada.
  19. Health Canada-Emergency Drug Release Form. HealthCanada.
  20. Health Canada-Special Access Programme. HealthCanada.
  21. FDA no longer issuing letters for importation of unapproved animal drugs. JAVMA News (15 October 2009).
  22. Insuvet. NOAH Compendium-UK.
  23. Hypurin Bovine Neutral. Wockhardt UK.
  24. Insuvet Uses. NOAH Compendium-UK.
  25. Patient Information-Hypurin Bovine Neutral. Net
  26. Prescribing Bovine Insulin.
  27. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  28. Insuvet-Pharmaceutical Information. NOAH Compendium-UK.
  29. Insuvet-Dosage and Administration. NOAH Compendium-UK.

Related pages
Lilly human insulins1992charts
Cp wockhardt bovine insulins
Betasint Bovine Corriente
Iletin R
Hypurin Bovine Neutral
Hypurin Vet Neutral