Canine Diabetes Wiki
Insuman Rapid
R, Neutral by Aventis
U40, U100 none
Action in dogs:
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h [1]
Line: Insuman
Also known as: Winthrop Rapid
Similar to: Actrapid, Novolin R, ReliOn/Novolin R
Huminsulin Normal, Humulin C, Humulin R
Humuline R, Humulin S, Humuline Regular
Humulin Regular, Humulina Regular
Humulin ReliOn R, Umuline Rapide
Umuline Regular

Names of Lilly r-DNA/GE/GM insulins worldwide
Use and Handling:
Shelf Life: 24 months Type: soluble, clear
When Opened: 4 weeks, below 25C
In Pen: 4 weeks, below 25C
Notes: Protect from light and heat
Do Not Freeze,
May be used intravenously

Insuman Rapid-French packaging. Note similarities with packages for Humulin S and Humulin R.

Note that some countries have the brand name in U40 strength.

Insuman Rapid is Aventis' brand name for its r-DNA/GE/GM short-acting insulin [2] in its Insuman line of products. [3][4]

Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed. [5]

Other brands of the same type of insulin are: Humulin R [6] and Humulin S [7][8][9] by Eli Lilly--Actrapid [10][11] and Novolin R by Novo Nordisk. [12]

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [13] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [14]

The very small insulin particles in semilente insulin are suspended by zinc. [13] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [15][16] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [13]

R/Neutral Insulins[]


  1. Insulins. North American Veterinary Conference Clinicians Brief (2006).
  2. Patient Information Leaflet-Insuman Rapid. Sanofi-Aventis.
  3. Aventis Poster-Insuman & Lantus Insulins. Sanofi-Aventis.
  4. Scientific Discussion-Insuman. EMEA.
  5. Humulin R patient leaflet. Eli Lilly.
  6. Humulin R Regular Human Insulin. Revolution Health.
  7. Patient information Leaflet-Humulin S. Eli Lilly.
  8. Humulin S Prescribing Information.
  9. Lilly EU/UK Product Sheer & Time Activity Profiles. Eli Lilly.
  10. Scientific Discussion-Actrapid. EMEA.
  11. Prescribing Novo Insulins.
  12. Novolin R. Revolution Health.
  13. 13.0 13.1 13.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content
  14. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  15. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  16. Resource Guide. American Diabetes Association (2005).

More Information[]

Related Pages
Rtap HumilinLILLY 21944f Rtap Actrapid
Humulin ReliOn R
Humulin R
Humulin S
Winthrop Rapid