| Insuman Rapid | |
|---|---|
| R, Neutral by Aventis | |
| short-acting | |
| r-DNA/GE/GM | |
| U40, U100 | none |
Action in dogs:
| |
| Line: Insuman | |
| Also known as: Winthrop Rapid | |
| Similar to: Actrapid, Novolin R, ReliOn/Novolin R Huminsulin Normal, Humulin C, Humulin R Humuline R, Humulin S, Humuline Regular Humulin Regular, Humulina Regular Humulin ReliOn R, Umuline Rapide Umuline Regular Names of Lilly r-DNA/GE/GM insulins worldwide | |
| Use and Handling: | |
| Shelf Life: 24 months | Type: soluble, clear |
| When Opened: 4 weeks, below 25C | |
| In Pen: 4 weeks, below 25C | |
| Notes: Protect from light and heat Do Not Freeze, May be used intravenously | |
Insuman Rapid-French packaging. Note similarities with packages for Humulin S and Humulin R.
|
Note that some countries have the brand name in U40 strength. | ||
Insuman Rapid is Aventis' brand name for its r-DNA/GE/GM short-acting insulin [2] in its Insuman line of products. [3][4]
Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed. [5]
Other brands of the same type of insulin are: Humulin R [6] and Humulin S [7][8][9] by Eli Lilly--Actrapid [10][11] and Novolin R by Novo Nordisk. [12]
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [13] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [14]
The very small insulin particles in semilente insulin are suspended by zinc. [13] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [15][16] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [13]
R/Neutral Insulins[]
|
R/Neutral Insulins | |
|---|---|
|
All Short acting All soluble |
| Hypurin Bovine Neutral Betasint Bovine Corriente | |
| Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) Insuvet Neutral (No longer produced.) | |
| Iletin I R (No longer produced.) | |
| Betasint Porcine Corriente Hypurin Porcine Neutral Hypurin Pork Regular Maxirapid CHO | |
| Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
| Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, Umuline Rapide Umuline Regular, Winthrop Rapid Humulin ReliOn R | |
| R-DNA | ReliOn/Novolin R (No longer produced.) |
References[]
- ↑ Insulins. North American Veterinary Conference Clinicians Brief (2006).
- ↑ Patient Information Leaflet-Insuman Rapid. Sanofi-Aventis.
- ↑ Aventis Poster-Insuman & Lantus Insulins. Sanofi-Aventis.
- ↑ Scientific Discussion-Insuman. EMEA.
- ↑ Humulin R patient leaflet. Eli Lilly.
- ↑ Humulin R Regular Human Insulin. Revolution Health.
- ↑ Patient information Leaflet-Humulin S. Eli Lilly.
- ↑ Humulin S Prescribing Information.
- ↑ Lilly EU/UK Product Sheer & Time Activity Profiles. Eli Lilly.
- ↑ Scientific Discussion-Actrapid. EMEA.
- ↑ Prescribing Novo Insulins.
- ↑ Novolin R. Revolution Health.
- ↑ 13.0 13.1 13.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid
<ref>tag; name "Auburn" defined multiple times with different content - ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
Note--in 1980, there were no r-DNA/GE/GM insulins - ↑ Resource Guide. American Diabetes Association (2005).
More Information[]
- PDF of Insuman and Lantus info sheet Yorkshire Diabetes
- NACDS-Insulin Chart-Page 2
- Leeds NHS UK Insulin Guide
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of regular/normal/neutral insulins.
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