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Insuman Comb 30
R/Neutral/NPH/Isophane Mix by Aventis
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Insuman
Also known as Winthrop Comb 30
Similar to  
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 24 months
When opened 4 weeks room temp.
In pen 4 weeks room temp.
Notes  
  • protect from light and heat
  • Do Not Freeze
  • Do not use if product does not re-suspend
  • Roll
  • Do not use intravenously
  • Do not refrigerate in use cartridges/pens.
Insuman

Insuman insulins in pen cartridge form.


This 70% NPH/isophane crystal[2] and 30% R/neutral insulin mix[3][4] is intermediate-acting and made by Aventis as part of its Insuman line of products[5].

While this type of Insuman insulin is approved and sold in the EU and elsewhere, it is the only one of the Insuman insulins not offered in the UK.

Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.

For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70[6]. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.

The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:

Non-Analog Mixed Insulins
Intermediate acting All Intermediate-acting
Expressed As Expressed As Insulin Is
10/90 90/10 10% R/Neutral Insulin
90% NPH/Isophane Insulin
20/80 80/20 20% R/Neutral Insulin
80% NPH/Isophane Insulin
30/70 70/30 30% R/Neutral Insulin
70% NPH/Isophane Insulin
40/60 60/40 40% R/Neutral Insulin
60% NPH/Isophane Insulin
50/50 50/50 50% R/Neutral Insulin
50% NPH/Isophane Insulin

References

  1. Medsafe NZ Penmix 30
  2. EMEA-Insuman Line of Insulins
  3. Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Comb 25
  4. Insuman Prescribing Information
  5. Aventis Poster-Insuman & Lantus Insulins
  6. Humulin 10/90-NPH;R Human Insulin Remedyfind.com


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