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*[[Novolin 30R]] |
*[[Novolin 30R]] |
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*[[Novolin 70/30]] |
*[[Novolin 70/30]] |
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| − | *[[Penmix 30]]<ref> |
+ | *[[Penmix 30]]<ref>{{cite web|url=http://www.medsafe.govt.nz/Profs/DataSheet/PenmixMixtardProtaphaneinj.htm|title=Penmix 30|publisher= Medsafe NZ}}</ref> |
*[[Profil 30]] |
*[[Profil 30]] |
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*[[ReliOn/Novolin 70/30]] |
*[[ReliOn/Novolin 70/30]] |
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*Do not refrigerate in use cartridges/pens. |
*Do not refrigerate in use cartridges/pens. |
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}} |
}} |
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| − | [[Image:Insuman.PNG|thumb|left|300px|Insuman insulins in pen cartridge form.]]<br clear=left>This 70% NPH/isophane crystal<ref> {{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000201/WC500033779.pdf|title=Scientific Discussion-Insuman|publisher=EMEA}}</ref> and 30% R/neutral insulin mix<ref> |
+ | [[Image:Insuman.PNG|thumb|left|300px|Insuman insulins in pen cartridge form.]]<br clear=left>This 70% NPH/isophane crystal<ref> {{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000201/WC500033779.pdf|title=Scientific Discussion-Insuman|publisher=EMEA}}</ref> and 30% R/neutral insulin mix<ref>{{cite web|url=http://images2.wikia.nocookie.net/diabetesindogs/images/7/7f/Insuman_Comb_25_patient_info_leaflet.pdf |title=Patient Information Leaflet-Insuman Comb 25|publisher=Sanofi-Aventis}}</ref><ref>{{cite web|url=http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Insuman_insulins.htm |title=Insuman Prescribing Information}}</ref> is intermediate-acting and made by [[Aventis]] as part of its Insuman line of products.<ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/A11456_Range_Poster.pdf |title=Aventis Poster-Insuman & Lantus Insulins|publisher=Sanofi-Aventis}}</ref><ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000201/WC500033779.pdf|title=Scientific Discussion-Insuman|publisher=EMEA}}</ref> |
While this type of Insuman insulin is approved and sold in the EU and elsewhere, it is the only one of the Insuman insulins not offered in the UK. |
While this type of Insuman insulin is approved and sold in the EU and elsewhere, it is the only one of the Insuman insulins not offered in the UK. |
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Revision as of 19:24, 17 August 2010
| Insuman Comb 30 | |
| R/Neutral/NPH/Isophane Mix by Aventis | |
| intermediate-acting | r-DNA/GE/GM |
| U100 | isophane |
| Line | Insuman |
| Also known as | Winthrop Comb 30 |
| Similar to | |
| Action in dogs |
|
| Use and Handling | |
|---|---|
| Type | cloudy |
| Shelf Life | 24 months |
| When opened | 4 weeks room temp. |
| In pen | 4 weeks room temp. |
| Notes |
|
Insuman insulins in pen cartridge form.
This 70% NPH/isophane crystal[2] and 30% R/neutral insulin mix[3][4] is intermediate-acting and made by Aventis as part of its Insuman line of products.[5][6]
While this type of Insuman insulin is approved and sold in the EU and elsewhere, it is the only one of the Insuman insulins not offered in the UK.
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
| Non-Analog Mixed Insulins | ||
|---|---|---|
|
All Intermediate-acting | |
| Expressed As | Expressed As | Insulin Is |
|---|---|---|
| 10/90 | 90/10 | 10% R/Neutral Insulin 90% NPH/Isophane Insulin |
| 20/80 | 80/20 | 20% R/Neutral Insulin 80% NPH/Isophane Insulin |
| 30/70 | 70/30 | 30% R/Neutral Insulin 70% NPH/Isophane Insulin |
| 40/60 | 60/40 | 40% R/Neutral Insulin 60% NPH/Isophane Insulin |
| 50/50 | 50/50 | 50% R/Neutral Insulin 50% NPH/Isophane Insulin |
References
- ↑ Penmix 30. Medsafe NZ.
- ↑ Scientific Discussion-Insuman. EMEA.
- ↑ Patient Information Leaflet-Insuman Comb 25. Sanofi-Aventis.
- ↑ Insuman Prescribing Information.
- ↑ Aventis Poster-Insuman & Lantus Insulins. Sanofi-Aventis.
- ↑ Scientific Discussion-Insuman. EMEA.