|Insuman Comb 30|
|R/Neutral/NPH/Isophane Mix by Aventis|
|Also known as||Winthrop Comb 30|
|Action in dogs||
|Use and Handling|
|Shelf Life||24 months|
|When opened||4 weeks room temp.|
|In pen||4 weeks room temp.|
This 70% NPH/isophane crystal and 30% R/neutral insulin mix is intermediate-acting and made by Aventis as part of its Insuman line of products.
While this type of Insuman insulin is approved and sold in the EU and elsewhere, it is the only one of the Insuman insulins not offered in the UK.
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
|Non-Analog Mixed Insulins|
|Expressed As||Expressed As||Insulin Is|
|10/90||90/10||10% R/Neutral Insulin|
90% NPH/Isophane Insulin
|20/80||80/20||20% R/Neutral Insulin|
80% NPH/Isophane Insulin
|30/70||70/30||30% R/Neutral Insulin|
70% NPH/Isophane Insulin
|40/60||60/40||40% R/Neutral Insulin|
60% NPH/Isophane Insulin
|50/50||50/50||50% R/Neutral Insulin|
50% NPH/Isophane Insulin
- ↑ Medsafe NZ Penmix 30
- ↑ EMEA-Insuman Line of Insulins
- ↑ Electronic Medicines Compendium (EMC) UK-Patient Information Leaflet-Insuman Comb 25
- ↑ Insuman Prescribing Information
- ↑ Aventis Poster-Insuman & Lantus Insulins
- ↑ Humulin 10/90-NPH;R Human Insulin Remedyfind.com