Canine Diabetes Wiki
Insuman Basal
NPH/Isophane by Aventis
U40, U100 isophane
Action in dogs:
  • onset 0.5-3h,
  • peak 2-10h, [1]
  • duration 4-24h [2]
Line: Insuman
Also known as: Insuhuman Basal, Isuhuman Basal, Winthrop Basal
Similar to: Humulin I, Huminsulin Basal, Humulin N, Humulin NPH, Humulina NPH, Humuline NPH, Humuline N, Umuline NPH, Humulin ReliOn 70/30
Insulatard, Novolin N, Protaphan, Protaphane
ReliOn/Novolin NPH

Names of Lilly r-DNA/GE/GM insulins worldwide
Use and Handling:
Shelf Life: 24 months Type: cloudy
When Opened: 4 weeks room temp.
In Pen: 4 weeks room temp.
Notes: Protect from light and heat
Do Not Freeze, Resuspend
Do not use if product does not re-suspend
Do not use intravenously [3]

Insuman Basal-French package. Note the similarities in the packages of Humulin I and Humulin N.

Note that some countries have the brand name in U40 strength.

This is Aventis' brand name for its NPH/isophane suspension insulin, [4][5][6][7] which is intermediate-acting.

Both Novo Nordisk and Eli Lilly produce similar insulins under the names Novolin N, [8] Insulatard, [9] Protaphane, [10] Humulin N[11][12], Umuline NPH, Humulina NPH,Humuline NPH, Huminsulin Basal and Humulin I. [13][14][15]

Like all other isophane/protamine suspended insulins, it is a crystalline suspension with protamine.

This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.

Specifications of NPH/isophane insulin[]

British National Formulary [16] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.

British Pharmacoepia and United States Pharmacopia definitions: [17]

Isophane Insulin

Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.

USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.

NPH/isophane insulins[]

The following commercial insulins are all generically NPH insulins:

Other commonly used names are:

  • NPH insulin, NPH
  • isophane insulin


More Information[]

Related Pages
21938f Humulin n NVN34740 72167 5 NPHtap Insulatard Protaphan2
Humulin I
Humulin N
Novolin N
Winthrop Basal