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Insulinum semilente CHO

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Insulinum Semilente CHO
Semilente by Polfa Tarchomin
short-acting
Porcine
U80 Zinc
Action in dogs:
  • onset within 45 minutes,
  • peak 2-4h,
  • duration 4-6h
Line:
Also known as: pork semilente, semilente pork
Similar to: Novo Semilente MC, Semitard [1]
Use and Handling:
Shelf Life: 36 months Type: cloudy
When Opened: 6 weeks room temp.
In Pen: N/A
Notes: Protect from light and heat
Do Not Freeze,
Re-suspend
Do not use if product does not re-suspend
Do not use intravenously [2]
Do not mix with non Lente-type insulins
Lente insuline

Novo Nordisk Semilente MC 40- Porcine (Pork) Insulin-German Packaging. This is semilente pork insulin (Insulin vom Schwein) in U40 strength. Novo discontinued this insulin; Polfa-Tarchomin's Insulinum semilente CHO is a U80 replacement for it.


This [3][4] is the last "plain" semilente insulin in production. Novo Nordisk distributed their Novo Semilente MC in Germany, but not in places like the US, Canada and the UK. Semilente insulin [5] has an activity pattern similar to that of R/Neutral.

When Novo discontinued this insulin, it was Polfa Tarchomin [6] who agreed to produce Insulinum semilente CHO as a replacement for it; if they hadn't, there would be no more "standalone" semilente insulins available.

What Semilente Is Not[]

No Lente-type insulin regardless of species can contain any NPH/isophane insulin [7] or any R/Neutral insulin. [8][9]

Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral. [10]

The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect. [11][12]

Before the invention of VetPen, Lente-type insulins could not be dispensed in pen or cartridge form because the glass ball formerly used to mix the insulin in these devices shattered the Lente crystals.[13]

Combining Lente Family Insulins[]

None of the Lente family of insulins (semilente, Lente, Ultralente) can be combined with [10] NPH/isophane insulins. The phenol preservatives present in NPH-type insulins alters the Lente-types to the point where they become a close approximation of R/neutral, with regard to action. [10][14]

Keeping the phenol preservatives in mind, all protamine-suspended insulin mixes would be "off limits" regarding same syringe mixing with any Lente-type insulins. [14]

Insulin manufacturers [15] indicate that R/neutral and semilente, Lente, ultralente insulins are able to be combined in the same syringe, but only just before injection. In pre-filled syringes, the zinc suspension of the Lente-type insulins binds the R/neutral, causing it to lose its short-acting effect. Various studies have documented this, and some doctors advise against using R/neutral in the same syringe with the Lente family of insulins. [9][16][17][14]

References[]

  1. ↑ Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  2. ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  3. ↑ Insulinum semilente CHO. Diabetes news.de.
  4. ↑ Google Translated Page for Insulinum semilente CHO. Polfa Tarchomin.
  5. ↑ Dumitriu, Severian (2001). Polymeric Biomaterials, Revised and Expanded 1104. CRC Press.
  6. ↑ About Polfa Tarchomin. Polfa Tarchomin.
  7. ↑ Combining Lente-type Insulins with Phenol-Preserved Insulins. National Federation for the Blind.
  8. ↑ Lente Zinc Suspension Causes Loss Of R/Neutral Short-Acting Effect. Endotext.org.
  9. ↑ 9.0 9.1 Huffman DM, Garber AJ. (1991). Availability of Soluble (R/Neutral) Insulin in Mixed Preparations With Crystalline (Lente) & Ultralente GE Insulin. Clinical Therapeutics. Cite error: Invalid <ref> tag; name "Huffman" defined multiple times with different content
  10. ↑ 10.0 10.1 10.2 Lente-Type Insulins & NPH/Isophane Insulins-A Bad Combination. National Federation for the Blind. Cite error: Invalid <ref> tag; name "Bad" defined multiple times with different content
  11. ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  12. ↑ Resource Guide. American Diabetes Association (2005).
  13. ↑ Hanas, Ragnar (1999). Insulin-Dependent Diabetes-Page 10. ChildrenWithDiabetes.
  14. ↑ 14.0 14.1 14.2 Insulin Therapy-Mixing Precautions. RxEd.org. Cite error: Invalid <ref> tag; name "Rx" defined multiple times with different content
  15. ↑ Insulin Producers vs Doctors Re:Combining R/Neutral & Lente-type Insulins. Endotext.org.
  16. ↑ Bilo HJ, Heine RJ, Sikkenk AC, van der Meer J, van der Veen EA. (1987). Absorption Kinetics & Action Profiles-Single Subcutaneous Administration of Human Soluble (R/Neutral) & Lente Insulin. Diabetes Care.
  17. ↑ Heine RJ, Sikkenk AC, Eizenga WH, van der Veen EA. (1983). Delayed Onset of Action of Soluble (R/Neutral) Insulin After Premixing With Lente Insulin Diabetes. Research & Clinical Practice.

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