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| − | {{Insulin| |
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| + | ! colspan="2" style="background:#cae1ff; width:300px;font-size:10pt" | Insuhuman Comb 50 |
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| − | bgcolor=#cae1ff| |
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| + | |- |
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| − | fgcolor=#000080| |
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| + | | colspan="2" style="background:aliceblue; width:300px; text-align:center;font-size:9pt" |[[Mixed insulins|R/Neutral/NPH/Isophane Mix]] by [[Aventis]] |
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| − | name=Insuhuman Comb 50| |
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| + | |- |
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| − | generic=[[Mixed insulins|R/Neutral/NPH/Isophane Mix]]| |
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| + | |colspan="2" style="background:#bcd2ee; width:300px; text-align:center;font-size:9pt"|[[intermediate-acting]] |
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| − | mfg=[[Aventis]]| |
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| + | |- |
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| − | |- align="center" style="background:#cae1ff;border-bottom:3px solid grey;"| |
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| + | | colspan="2" style="background:#bcd2ee; width:300px; text-align:center;font-size:9pt"|[[r-DNA/GE/GM]] |
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| − | action=[[intermediate-acting]]| |
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| + | |- |
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| − | origin=[[r-DNA/GE/GM]]| |
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| + | ! colspan="1" style="background:#bcd2ee; width:150px; text-align:center;font-size:9pt" | U40, U100 |
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| − | strength=U40, U100| |
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| + | |colspan="1" style="background:#bcd2ee; width:150px;text-align:center;font-size:9pt"|[[isophane]] |
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| − | suspension=[[Isophane]]| |
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| + | |- |
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| − | line=[[Insuman]]| |
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| + | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Action in dogs:''' |
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| − | aliases=[[Insuman Comb 50]], [[Winthrop Comb 50]]| |
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| − | similar= |
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| − | *[[Actraphane 50/50]] |
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| − | *[[Huminsulin 50/50]] |
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| ⚫ | |||
| ⚫ | |||
| − | *[[Humuline 50/50]] |
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| ⚫ | |||
| − | *[[Penmix 50]]<ref>{{cite web|url=http://www.medsafe.govt.nz/Profs/DataSheet/PenmixMixtardProtaphaneinj.htm |title=Penmix 50|publisher=Medsafe NZ}}</ref> |
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| − | |||
| − | <br>[http://images3.wikia.nocookie.net/__cb20100602042136/diabetesindogs/images/2/23/WW_Humuline.pdf Names of Lilly r-DNA/GE/GM insulins worldwide]| |
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| − | dogaction= |
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*onset 0.5-3h, |
*onset 0.5-3h, |
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*peak 2-10h, |
*peak 2-10h, |
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| − | *duration 4-24h |
+ | *duration 4-24h |
| + | |- |
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| − | cloudyorsoluble=[[cloudy]]| |
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| + | | colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Line:''' [[Insuman]] |
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| − | shelflife= 24 months| |
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| + | |- |
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| − | openedlife= 4 weeksroom temp.| |
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| + | | colspan="2" style="background:aliceblue; width:300px; font-size:9pt;text-align:left"| '''Also known as:''' [[Insuman Comb 50]]<br>[[Winthrop Comb 50]] |
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| − | penlife= 4 weeks room temp.| |
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| + | |||
| − | handlingnotes= |
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| + | |- |
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| − | *protect from light and heat |
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| + | | colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''Similar to:''' [[Huminsulin 50/50]],[[Humulin M5]]<br>[[Humulin 50/50]],[[Humulina 50/50]], [[Humuline 50/50]]<br>[[Actraphane 50/50]], [[Mixtard 50]], [[Penmix 50]] <ref>{{cite web|url=http://www.medsafe.govt.nz/Profs/DataSheet/PenmixMixtardProtaphaneinj.htm|title=Penmix 50|publisher= Medsafe NZ}}</ref><br><br>[http://images3.wikia.nocookie.net/__cb20100602042136/diabetesindogs/images/2/23/WW_Humuline.pdf Names of Lilly r-DNA/GE/GM insulins worldwide] |
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| − | *Do Not Freeze |
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| + | |- |
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| − | *Do not use if product does not [[re-suspend]] |
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| + | | colspan="2" style="background:#cae1ff; width:300px;text-align:center;font-size:9pt" | '''Use and Handling:''' |
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| − | *[[Rolling insulin|Roll]] |
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| + | |- |
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| − | *Do not use [[intravenously]] |
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| + | | colspan="1" style="background:aliceblue; width:150px;font-size:9pt;text-align:left"| '''Shelf Life:''' 24 months |
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| − | *Do not refrigerate in use pens/cartridges. |
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| + | |colspan="1" style="background:aliceblue; width:150px;font-size:9pt;text-align:left" | '''Type:''' [[cloudy]] |
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| ⚫ | |||
| + | |- |
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| + | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''When Opened:''' 4 weeks room temp. |
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| + | |- |
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| + | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''In Pen:''' 4 weeks room temp. |
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| + | |- |
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| + | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''Notes:''' Protect from light and heat<br> Do Not Freeze, [[Resuspending insulin|Resuspend]]<br> Do not use if product does not [[re-suspend]]<br>Do not use [[intravenously]] <ref>{{cite web|title=Small Animal Clinical Pharmacology|author=Maddison, Jill E.,Page, Stephen W.,Church, David B.|year=2008|publisher=Saunders Ltd.|isbn=0702028584|page=510|url=http://www.amazon.com/Animal-Clinical-Pharmacology-Maddison-DipVetClinStud/dp/0702028584/ref=sr_1_1?s=books&ie=UTF8&qid=1296451134&sr=1-1}}</ref> |
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| + | <br clear=left> |
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{| |
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| − | |style="padding:5px;border:2px solid #b9f1f0;background-color:#f0f8ff;" width=" |
+ | |style="padding:5px;border:2px solid #b9f1f0;background-color:#f0f8ff;" width="100%"| |
'''Note that some countries have the brand name in U40 strength.''' |
'''Note that some countries have the brand name in U40 strength.''' |
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| − | This is an [[Aventis]] mixed, intermediate-acting insulin<ref>{{cite web|url=http://images4.wikia.nocookie.net/diabetesindogs/images/8/8d/Insuman_comb_50_patient_info_leaflet.pdf |title=Patient Information Leaflet-Insuman Comb 50|publisher=Sanofi-Aventis}}</ref> comprised of 50% R/neutral and 50% NPH/isophane crystal insulin<ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000428/WC500029819.pdf|title=Scientific Discussion-Mixtard|publisher=EMEA}}</ref>, one of its Insuman line of products.<ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/A11456_Range_Poster.pdf |title=Aventis Poster-Insuman & Lantus Insulins|publisher=Sanofi-Aventis}}</ref><ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000201/WC500033779.pdf|title=Scientific Discussion-Insuman|publisher=EMEA}}</ref> |
+ | This is an [[Aventis]] mixed, intermediate-acting insulin <ref>{{cite web|url=http://images4.wikia.nocookie.net/diabetesindogs/images/8/8d/Insuman_comb_50_patient_info_leaflet.pdf |title=Patient Information Leaflet-Insuman Comb 50|publisher=Sanofi-Aventis}}</ref> comprised of 50% R/neutral and 50% NPH/isophane crystal insulin <ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000428/WC500029819.pdf|title=Scientific Discussion-Mixtard|publisher=EMEA}}</ref>, one of its Insuman line of products. <ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/A11456_Range_Poster.pdf |title=Aventis Poster-Insuman & Lantus Insulins|publisher=Sanofi-Aventis}}</ref><ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000201/WC500033779.pdf|title=Scientific Discussion-Insuman|publisher=EMEA}}</ref> |
| − | [[Eli Lilly]] produced a comparable insulin for North America: [[Humulin 50/50]]<ref>{{cite web|url=http://www.revolutionhealth.com/drugs-treatments/humulin-50-50 |title=Humulin 50/50-NPH;R Human Insulin|publisher= Remedyfind.com}}</ref>; they also formerly produced this insulin in the EU & UK under the brand name [[Humulin M5]]<ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/1071_LLY_Diabetes_RangeChar.pdf |title=Lilly EU/UK Product Sheet & Time Activity Profiles|publisher=Eli Lilly}}</ref> |
+ | [[Eli Lilly]] produced a comparable insulin for North America: [[Humulin 50/50]] <ref>{{cite web|url=http://www.revolutionhealth.com/drugs-treatments/humulin-50-50 |title=Humulin 50/50-NPH;R Human Insulin|publisher= Remedyfind.com}}</ref>; they also formerly produced this insulin in the EU & UK under the brand name [[Humulin M5]]. <ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/1071_LLY_Diabetes_RangeChar.pdf |title=Lilly EU/UK Product Sheet & Time Activity Profiles|publisher=Eli Lilly}}</ref> M5 was discontinued in July 2004. <ref>{{cite web|url=http://web.archive.org/web/20041205172554/http://www.diabetes.org.uk/infocentre/inform/insulinwithdrawal2004.htm |title=Withdrawal of Humulin M5|year=2004|publisher=Diabetes UK}}</ref> Other Lilly insulin that are similar are [[Humulina 50/50]] and [[Humuline 50/50]]. |
| − | [[Novo Nordisk]] produced two: [[Actraphane 50/50]]<ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000427/WC500025430.pdf|title=Scientific Discussion-Actraphane|publisher=EMEA}}</ref> and the now discontinued [[Mixtard 50]]<ref>{{cite web|url=http://www.leedsth.nhs.uk/sites/diabetes/information/InsulinMixtures.php |title=Insulins & Mixtures|publisher=NHS}}</ref> |
+ | [[Novo Nordisk]] produced two: [[Actraphane 50/50]] <ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000427/WC500025430.pdf|title=Scientific Discussion-Actraphane|publisher=EMEA}}</ref> and the now discontinued [[Mixtard 50]]. <ref>{{cite web|url=http://www.leedsth.nhs.uk/sites/diabetes/information/InsulinMixtures.php |title=Insulins & Mixtures|publisher=NHS}}</ref> |
[[Mixed insulins]] cover a wide range as they can be [[:Category:Origin|animal]] origin, [[r-DNA/GE/GM]] origin or [[analog]] insulins. The non-analog mixed insulins are made up of [[:Category:Intermediate-acting|intermediate-acting]] [[NPH]]/isophane insulin and [[:Category:Short-acting|short-acting]] [[R]]/neutral. normal insulin. The analog mixes are made from [[:Category:Intermediate-acting|intermediate-acting]] protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and [[:Category:Fast-acting|fast-acting]] analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin. |
[[Mixed insulins]] cover a wide range as they can be [[:Category:Origin|animal]] origin, [[r-DNA/GE/GM]] origin or [[analog]] insulins. The non-analog mixed insulins are made up of [[:Category:Intermediate-acting|intermediate-acting]] [[NPH]]/isophane insulin and [[:Category:Short-acting|short-acting]] [[R]]/neutral. normal insulin. The analog mixes are made from [[:Category:Intermediate-acting|intermediate-acting]] protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and [[:Category:Fast-acting|fast-acting]] analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin. |
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The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork [[Iletin]] and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion: |
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork [[Iletin]] and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion: |
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| − | {| align="center" width="500" border="1" bgcolor="powderblue"| |
+ | {| class="collapsible collapsed" align="center" width="500" border="1" bgcolor="powderblue"| |
| − | ! bgcolor=" |
+ | ! bgcolor="BCD2EE" colspan="3" |Non-Analog Mixed Insulins |
|- |
|- |
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! bgcolor="lightcyan" width="200" |[[Image:Intermediate_acting.jpg|200px]] |
! bgcolor="lightcyan" width="200" |[[Image:Intermediate_acting.jpg|200px]] |
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! bgcolor="#cae1ff" colspan="2" |All [[Intermediate-acting]] |
! bgcolor="#cae1ff" colspan="2" |All [[Intermediate-acting]] |
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| − | | |
+ | |- |
| ⚫ | |||
| ⚫ | |||
! colspan="1" bgcolor="aliceblue"| Expressed As |
! colspan="1" bgcolor="aliceblue"| Expressed As |
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!colspan="1" bgcolor="aliceblue"|Expressed As |
!colspan="1" bgcolor="aliceblue"|Expressed As |
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| ⚫ | |||
|- |
|- |
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| ⚫ | |||
! colspan="1" bgcolor="ivory"|10/90 |
! colspan="1" bgcolor="ivory"|10/90 |
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| ⚫ | |||
| ⚫ | |||
|- |
|- |
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| ⚫ | |||
| ⚫ | |||
! colspan="1" bgcolor="ivory"|20% [[R|R/Neutral Insulin]]<br />80% [[NPH|NPH/Isophane Insulin]] |
! colspan="1" bgcolor="ivory"|20% [[R|R/Neutral Insulin]]<br />80% [[NPH|NPH/Isophane Insulin]] |
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| ⚫ | |||
|- |
|- |
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| − | ! colspan="1" bgcolor="ivory"|30/ |
+ | ! colspan="1" bgcolor="ivory"|30% [[R|R/Neutral Insulin]]<br />80% [[NPH|NPH/Isophane Insulin]] |
!colspan="1" bgcolor="ivory"|70/30 |
!colspan="1" bgcolor="ivory"|70/30 |
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| − | ! colspan="1" bgcolor="ivory"|30 |
+ | ! colspan="1" bgcolor="ivory"|30/70 |
|- |
|- |
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| ⚫ | |||
| ⚫ | |||
! colspan="1" bgcolor="ivory"|40% [[R|R/Neutral Insulin]]<br />60% [[NPH|NPH/Isophane Insulin]] |
! colspan="1" bgcolor="ivory"|40% [[R|R/Neutral Insulin]]<br />60% [[NPH|NPH/Isophane Insulin]] |
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|- |
|- |
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! colspan="1" bgcolor="ivory"|50% [[R|R/Neutral Insulin]]<br />50% [[NPH|NPH/Isophane Insulin]] |
! colspan="1" bgcolor="ivory"|50% [[R|R/Neutral Insulin]]<br />50% [[NPH|NPH/Isophane Insulin]] |
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==References== |
==References== |
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| + | {{Reflist|colwidth=30em}} |
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| − | <references/> |
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| − | |||
==More Information== |
==More Information== |
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| − | *[http://www.yorkshirediabetes.com/downloads/A11456_Range_Poster.pdf |
+ | *[http://www.yorkshirediabetes.com/downloads/A11456_Range_Poster.pdf Chart of Insuman Insulin Ranges] Yorkshire Diabetes |
| − | *[http:// |
+ | *[http://images2.wikia.nocookie.net/__cb20100821055615/diabetesindogs/images/0/0a/NACDS_insulin_chart.pdf NACDS-Insulin Chart-Page 2] |
| + | |||
| + | |||
| + | <center>'''Related pages'''</center> |
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| + | {|align="center" width="600" |
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| + | |||
| + | |<center>[[Image:Humulin M5.JPG|90px]]</center> |
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| + | |<center>[[Image:Penfill Mixtard 50 1.jpg|120px]]</center> |
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| + | |<center>[[Image:Humu515m.jpg|120px]]</center> |
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| + | |<center>[[Image:Wp comb50 1.GIF|120px]]</center> |
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| + | |||
| + | |- |
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| + | |<center>[[Penmix 50]]</center> |
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| + | |||
| + | |} |
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[[Category:Content]] |
[[Category:Content]] |
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[[Category:Insulins]] |
[[Category:Insulins]] |
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[[Category:Aventis]] |
[[Category:Aventis]] |
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[[Category:Insuman]] |
[[Category:Insuman]] |
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| + | [[Category:Currently marketed insulins]] |
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Latest revision as of 23:24, 23 May 2012
| Insuhuman Comb 50 | |
|---|---|
| R/Neutral/NPH/Isophane Mix by Aventis | |
| intermediate-acting | |
| r-DNA/GE/GM | |
| U40, U100 | isophane |
Action in dogs:
| |
| Line: Insuman | |
| Also known as: Insuman Comb 50 Winthrop Comb 50 | |
| Similar to: Huminsulin 50/50,Humulin M5 Humulin 50/50,Humulina 50/50, Humuline 50/50 Actraphane 50/50, Mixtard 50, Penmix 50 [1] Names of Lilly r-DNA/GE/GM insulins worldwide | |
| Use and Handling: | |
| Shelf Life: 24 months | Type: cloudy |
| When Opened: 4 weeks room temp. | |
| In Pen: 4 weeks room temp. | |
| Notes: Protect from light and heat Do Not Freeze, Resuspend Do not use if product does not re-suspend Do not use intravenously [2] | |
Time activity profile for 50/50 insulins.
|
Note that some countries have the brand name in U40 strength. | ||
This is an Aventis mixed, intermediate-acting insulin [3] comprised of 50% R/neutral and 50% NPH/isophane crystal insulin [4], one of its Insuman line of products. [5][6]
Eli Lilly produced a comparable insulin for North America: Humulin 50/50 [7]; they also formerly produced this insulin in the EU & UK under the brand name Humulin M5. [8] M5 was discontinued in July 2004. [9] Other Lilly insulin that are similar are Humulina 50/50 and Humuline 50/50.
Novo Nordisk produced two: Actraphane 50/50 [10] and the now discontinued Mixtard 50. [11]
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
| Non-Analog Mixed Insulins | ||
|---|---|---|
|
All Intermediate-acting | |
| Insulin Is | Expressed As | Expressed As |
| 10% R/Neutral Insulin 90% NPH/Isophane Insulin |
90/10 | 10/90 |
| 20% R/Neutral Insulin 80% NPH/Isophane Insulin |
80/20 | 20/80 |
| 30% R/Neutral Insulin 80% NPH/Isophane Insulin |
70/30 | 30/70 |
| 40% R/Neutral Insulin 60% NPH/Isophane Insulin |
60/40 | 40/60 |
| 50% R/Neutral Insulin 50% NPH/Isophane Insulin |
50/50 | 50/50 |
References[]
- ↑ Penmix 50. Medsafe NZ.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Patient Information Leaflet-Insuman Comb 50. Sanofi-Aventis.
- ↑ Scientific Discussion-Mixtard. EMEA.
- ↑ Aventis Poster-Insuman & Lantus Insulins. Sanofi-Aventis.
- ↑ Scientific Discussion-Insuman. EMEA.
- ↑ Humulin 50/50-NPH;R Human Insulin. Remedyfind.com.
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Withdrawal of Humulin M5. Diabetes UK (2004).
- ↑ Scientific Discussion-Actraphane. EMEA.
- ↑ Insulins & Mixtures. NHS.
More Information[]
- Chart of Insuman Insulin Ranges Yorkshire Diabetes
- NACDS-Insulin Chart-Page 2
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