Canine Diabetes Wiki
Insuhuman Comb 15
R/Neutral/NPH/Isophane Mix by Aventis
U40, U100 isophane
Action in dogs:
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Line: Insuman
Also known as: Insuman Comb 15
Winthrop Comb 15
Similar to: N/A

Names of Lilly r-DNA/GE/GM insulins worldwide
Use and Handling:
Shelf Life: 24 months Type: cloudy
When Opened: 4 weeks room temp.
In Pen: 4 weeks room temp.
Notes: Protect from light and heat
Do Not Freeze, Resuspend
Do not use if product does not re-suspend
Do not use intravenously [1]
Wp comb15 1

Time activity profile for Insuman Comb 15.

Note that some countries have the brand name in U40 strength.

Aventis produces this intermediate-acting mix of 15% R/neutral and 85% NPH/isophane crystal insulin [2][3] as part of its Insuman line of products.[4][5]

Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.

For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.

The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:


  1. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  2. Scientific Discussion-Mixtard. EMEA.
  3. Patient Information Leaflet-Insuman Comb 15. Sanofi-Aventis.
  4. Aventis Poster-Insuman & Lantus Insulins. Sanofi-Aventis.
  5. Scientific Discussion-Insuman. EMEA.

More Information[]

Related pages
Wp comb15 1
Wp comb15 1
Insuman Comb 15
Winthrop Comb 15