| Iletin R | |
|---|---|
| R, Neutral by Eli Lilly | |
| short-acting | |
| Bovine | |
| U100 | none |
Action in dogs:
| |
| Line: Iletin | |
| Also known as: Beef R, beef neutral | |
| Similar to: Hypurin Bovine Neutral Hypurin Vet Neutral, Betasint Bovine Corriente Insuvet Neutral | |
| Use and Handling: | |
| Shelf Life: 24 months | Type: soluble, clear |
| When Opened: 28 days room temp. | |
| In Pen: N/A | |
| Notes: Protect from light and heat Do Not Freeze, May be used intravenously See Insuvet Neutral, Hypurin Bovine Neutral or Betasint Bovine Corriente for current handling information for beef R/neutral insulin. | |
|
Note that some countries have the brand name in U40 strength. | ||
North American brand name for Eli Lilly's 100% bovine insulins [1]. This is the "R"/neutral or soluble type; many more types were also produced.
Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed. [2] There are no beef/pork mixed R/neutral insulins on the market today--they are all either pure pork or pure beef.
The pure beef Iletin R is equivalent to current insulins Hypurin Bovine Neutral and Betasint Bovine Corriente. [3][4][5]
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [6] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [7]
The very small insulin particles in semilente insulin are suspended by zinc. [6] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [8][9] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin [6].
R/Neutral Insulins[]
|
R/Neutral Insulins | |
|---|---|
|
All Short acting All soluble |
| Hypurin Bovine Neutral, Insuvet Neutral Betasint Bovine Corriente | |
| Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) | |
| Iletin I R (No longer produced.) | |
| Hypurin Porcine Neutral Hypurin Pork Regular Betasint Porcine Corriente, Maxirapid CHO | |
| Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
| Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, Umuline Rapide Umuline Regular, Winthrop Rapid Humulin ReliOn R | |
| R-DNA | ReliOn/Novolin R (No longer produced.) |
References[]
- ↑ Discontinuation of Lilly Iletin I line of beef/pork insulins. Iletin I R is at left.. Eli Lilly.
- ↑ Humulin R patient leaflet. Eli Lilly.
- ↑ Patient Information-Hypurin Bovine Neutral. Net Doctor uk.
- ↑ Hypurin Bovine Neutral. Wockhardt UK.
- ↑ Prescribing Bovine Insulin.
- ↑ 6.0 6.1 6.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid
<ref>tag; name "Auburn" defined multiple times with different content - ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
Note--in 1980, there were no r-DNA/GE/GM insulins - ↑ Resource Guide. American Diabetes Association (2005).
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