| Iletin I NPH | |
|---|---|
| NPH/Isophane by Eli Lilly | |
| intermediate-acting | |
| Bovine 85% Porcine 15% | |
| U100 | Isophane |
Action in dogs:
| |
| Line: Iletin | |
| Also known as: | |
| Similar to: | |
| Use and Handling: | |
| Shelf Life: 24 months | Type: cloudy |
| When Opened: 28 days room temp. | |
| In Pen: N/A | |
| Notes: Protect from light and heat Do Not Freeze, Re-suspend Do not use if product does not re-suspend Do not use intravenously [1] See Hypurin Bovine Isophane or Betasint Bovine NPH for current handling notes for bovine NPH insulin. | |
 Iletin I NPH.isophane beef/pork insulin. The insulin was discontinued by Lilly in 1998. |
 Lilly insulin products-1992. This insulin is shown as Iletin I NPH. |
|
Note that some countries have the brand name in U40 strength. | ||
An 85% beef. 15% pork NPH/isophane suspended insulin formerly made by Eli Lilly. [2]
Like all other isophane/protamine suspended insulins, [3] it was a crystalline suspension with protamine and zinc. [4]
The closest currently marketed equivalent is Hypurin Bovine Isophane [5][6], made by CP Pharma [7] and Betasint Bovine Lente by Beta Laboratorios.
Specifications of NPH/isophane insulin[]
British National Formulary [8] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.
British Pharmacoepia and United States Pharmacopia definitions: [8]
Isophane Insulin
Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.
USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.
NPH/isophane insulins[]
The following commercial insulins are all generically NPH insulins:
|
NPH/Isophane Insulins | |
|---|---|
|
All Intermediate acting |
| Betasint Bovine NPH Hypurin Bovine Isophane [9][6][10] | |
| Iletin NPH
(No longer produced.) | |
| Iletin I NPH
(No longer produced.) | |
| Betasint Porcine NPH Hypurin Porcine Isophane [11][12] Hypurin Pork NPH | |
| Iletin II NPH (No longer produced.) Pork Insulatard [11][13][14] (No longer produced.) Leo Retard (No longer produced.) | |
| Huminsulin Basal, Humulin I Humulin N, Humulin NPH Humulina NPH, Humuline N Humuline NPH, Umuline NPH Humulin ReliOn N | |
| Insuhuman Basal, Insuman Basal Isuhuman Basal, Winthrop Basal | |
| Insulatard, Novolin N Protaphan, Protaphane | |
| ReliOn/Novolin NPH (No longer produced) | |
Other commonly used names are:
- NPH insulin, NPH
- isophane insulin
References[]
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Insulin Update-Discontinuation of Iletin Beef/Pork insulins
- ↑ Humulin N patient leaflet. Eli Lilly.
- ↑ Discontinuation of Iletin I Beef/Pork line of Insulins. Iletin I N is shown at middle.
- ↑ Hypurin Bovine Isophane Patient Information. Net Doctor UK.
- ↑ 6.0 6.1 Hypurin Bovine Isophane. Wockhardt UK.
- ↑ Prescribing Bovine Insulin.
- ↑ 8.0 8.1 British National Formulary-Isophane/NPH Insulin Definition. InChem. Cite error: Invalid
<ref>tag; name "InChem" defined multiple times with different content - ↑ Hypurin Bovine Isophane Patient Information. Net Doctor uk.
- ↑ Prescribing Bovine Insulin.
- ↑ 11.0 11.1 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK. Cite error: Invalid
<ref>tag; name "Wockhardt" defined multiple times with different content - ↑ Prescribing Porcine Insulin.
- ↑ Prescribing Novo Animal Insulin.
- ↑ Patient Information Leaflet-Pork Insulatard. Novo Nordisk.
More information[]
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of Iletin insulins.