| Iletin II NPH | |
|---|---|
| NPH/isophane by Eli Lilly | |
| intermediate-acting | |
| Porcine | |
| U100 | isophane |
Action in dogs:
| |
| Line: Iletin | |
| Also known as: pork NPH, pork isophane | |
| Similar to: Betasint Porcine NPH Hypurin Porcine Isophane, Hypurin Pork NPH Leo Retard, [1] Pork Insulatard [2] | |
| Use and Handling: | |
| Shelf Life: 24 months | Type: cloudy |
| When Opened: 28 days room temp. | |
| In Pen: N/A | |
| Notes: Protect from light and heat Do Not Freeze, Re-suspend Do not use if product does not re-suspend Do not use intravenously [3] May be used intramuscularly, which means onset, peak and duration times are shorter. | |
Photo of Iletin II N-pork NPH.
|
Note that some countries have the brand name in U40 strength. | ||
North American brand name for Eli Lilly's 100% U100 porcine NPH/isophane insulin. [4][5]
Like all other Isophane/protamine suspended insulins, [6] it was a crystalline suspension with protamine and zinc. [7][8] No longer produced after July 2005. [9][10]
Identical insulins are: Hypurin Porcine Isophane, [11][12] Betasint Porcine NPH and Pork Insulatard [13][14] by Novo Nordisk, which was discontinued at the end of December 2007. [15]
Specifications of NPH/isophane insulin[]
British National Formulary [16] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.
British Pharmacoepia and United States Pharmacopia definitions: [16]
Isophane Insulin
Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.
USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.
NPH/isophane insulins[]
The following commercial insulins are all generically NPH insulins:
|
NPH/Isophane Insulins | |
|---|---|
|
All Intermediate acting |
| Betasint Bovine NPH Hypurin Bovine Isophane [17][18][19] | |
| Iletin NPH
(No longer produced.) | |
| Iletin I NPH
(No longer produced.) | |
| Betasint Porcine NPH Hypurin Porcine Isophane [2][5] Hypurin Pork NPH | |
| Iletin II NPH Pork Insulatard [2][4][14] (No longer produced.) Leo Retard (No longer produced.) | |
| Huminsulin Basal, Humulin I Humulin N, Humulin NPH Humulina NPH, Humuline N Humuline NPH, Umuline NPH Humulin ReliOn N | |
| Insuhuman Basal, Insuman Basal Isuhuman Basal, Winthrop Basal | |
| Insulatard, Novolin N Protaphan, Protaphane | |
| ReliOn/Novolin NPH (No longer produced) | |
Other commonly used names are:
- NPH insulin, NPH
- isophane insulin
References[]
- ↑ Montgomery, D. A. D.. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
- ↑ 2.0 2.1 2.2 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ 4.0 4.1 Prescribing Novo Animal Insulin. Cite error: Invalid
<ref>tag; name "Novo" defined multiple times with different content - ↑ 5.0 5.1 Prescribing Porcine Insulin. Cite error: Invalid
<ref>tag; name "Porcine" defined multiple times with different content - ↑ Humulin N patient information leaflet. Eli Lilly.
- ↑ Iletin II N-Us Packaging Photo.
- ↑ Iletin II NPH-Canadian Packaging Photo.
- ↑ Iletin II NPH Discontinuation Notice. US Food and Drug Administration (July 2005).
- ↑ Iletin II NPH/Iletin II R Discontinuation Sheet. Eli Lilly.
- ↑ Hypurin Porcine Isophane Prescribing Information. Net Doctor uk.
- ↑ Hypurin Porcine Isophane. Wockhardt UK.
- ↑ Pork Insulatard Patient Information. Net Doctor uk.
- ↑ 14.0 14.1 Patient Information Leaflet-Pork Insulatard. Novo Nordisk.
- ↑ Pork Insulatard Discontinuation Notice. Novo Nordisk.
- ↑ 16.0 16.1 British National Formulary-Isophane/NPH Insulin Definition. InChem. Cite error: Invalid
<ref>tag; name "InChem" defined multiple times with different content - ↑ Hypurin Bovine Isophane Patient Information. Net Doctor uk.
- ↑ Hypurin Bovine Isophane. Wockhardt UK.
- ↑ Prescribing Bovine Insulin
More information[]
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of Iletin insulins. - Insulin pork isophane (NPH)
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