| Iletin II Lente | |
| Lente by Eli Lilly | |
| intermediate-acting | Porcine |
| U40, U100 | Zinc |
| Line | Iletin |
| Also known as | pork lente |
| Similar to |
|
| Action in dogs |
|
| Use and Handling | |
|---|---|
| Type | cloudy |
| Shelf Life | 24 months |
| When opened | 28 days room temp. |
| In pen | N/A |
| Notes |
|
Iletin II Lente-U100 pork insulin by Lilly. This was discontinued in 2003.
|
Note that some countries have the brand name in U40 strength. | ||
A 100% porcine U100 insulin formerly produced by Eli Lilly[3], discontinued in 2003[4] and comprised of 30% semilente insulin and 70% Ultralente insulin.
Like all other Lente insulins[5][6] it was a suspension of crystalline (ultralente) and amorphous (semilente) insulins in the ratio shown above.[7]
It is identical to Monotard Pork, which Novo Nordisk also used to produce, and to Betasint Porcine Lente U100. It is also identical to Caninsulin[8][9] and Vetsulin in all respects except strength; they are U40 insulins. More equivalents are Betasint Porcine Lente in U 40 and U80 strengths and Polfa Tarchomin's Lente CHO, which is a U80 insulin.
What Lente Is Not
No Lente-type insulin regardless of species can contain any NPH/isophane insulin[10] or any R/Neutral insulin[11][12].
Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral[13].
The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect[14][15].
Lente-type insulins cannot be dispensed in pen or cartridge form because the glass ball used to mix the insulin in these devices will shatter the Lente crystals[16].
Combining Lente Family Insulins
Insulin manufacturers[17] indicate that R/neutral and semilente, Lente, ultralente insulins are able to be combined in the same syringe, but only just before injection. In pre-filled syringes, the zinc suspension of the Lente-type insulins binds the R/neutral, causing it to lose its short-acting effect. Various studies have documented this, and some doctors advise against using R/neutral in the same syringe with the Lente family of insulins[18][19][20][21].
|
None of the Lente family of insulins (semilente, Lente, Ultralente) can be combined with[22] NPH/isophane insulins. The phenol preservatives present in NPH-type insulins alters the Lente-types to the point where they become a close approximation of R/neutral, with regard to action[23][24]. Keeping the phenol preservatives in mind, all protamine-suspended insulin mixes would be "off limits" regarding same syringe mixing with any Lente-type insulins[25]. | ||
|
Lente Insulins | |
|---|---|
|
Intermediate acting Non-soluble |
| Betasint Bovine Lente Hypurin Bovine Lente | |
| Iletin Lente (No longer produced.) Beef Lentard (No longer produced.) | |
| Iletin I Lente (No longer produced.)[26] Lentard MC (No longer produced.) | |
| Betasint Porcine Lente, Lente CHO | |
|
Iletin II Lente (No longer produced.)[27] | |
| Monotard, Novolin L (No longer produced.) Huminsulin L, Huminsulin Long Humutard, Humulin L Humulin Lenta, Humulin Lente Humulina L, Humuline Long Umuline Lente, Umuline Zinc Compose (No longer produced.) | |
The following are lente type zinc suspension insulins but since they are produced for use in animals, they are not found in BNF, but in its sister veterinary formulary.
|
Lente Insulins | |
|---|---|
|
|
Intermediate acting Non-soluble |
| Insuvet Lente | |
| Caninsulin, Vetsulin | |
These fall into the category of intermediate-length insulins.
References
- ↑ Dowling, Patricia (1995). Insulin Therapy for Dogs and Cats (page 2). Canadian Veterinary Journal.
- ↑ Ruchinsky, Renee, et. al. (2010). Diabetes Management Guidelines for Dogs and Cats-page 7. American Animal Hospital Association.
- ↑ Copy of Iletin II Lente Patient Information Leaflet. Drugs.com.
- ↑ Iletin II Lente Discontinuation Material. US Food and Drug Administration (2003).
- ↑ Scientific Discussion-Monotard. EMEA.
- ↑ Definition of Lente Insulin. Merck Manual.
- ↑ Iletin II Lente Carton.
- ↑ Horn, B., Mitten, RW. (2000). Evaluation of an insulin zinc suspension for control of naturally occurring diabetes mellitus in dogs. Australian Veterinary Journal.
Refers to the David B. Church Study Equating Caninsulin with Novo's old Pork Monotard - ↑ Correspondence re: Horn-Mitten Study. Australian Veterinary Journal (2001).
More Re: Caninsulin Being Equivalent to Pork Monotard - ↑ Combining Lente-type Insulins with Phenol-Preserved Insulins. National Federation for the Blind.
- ↑ Lente Zinc Suspension Causes Loss Of R/Neutral Short-Acting Effect. Endotext.org.
- ↑ Huffman DM, Garber AJ. (1991). Availability of Soluble (R/Neutral) Insulin in Mixed Preparations With Crystalline (Lente) & Ultralente GE Insulin. Clinical Therapeutics.
- ↑ Lente-Type Insulins & NPH/Isophane Insulins-A Bad Combination. National Federation for the Blind.
- ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
Note--in 1980, there were no r-DNA/GE/GM Lente or NPH insulins - ↑ Resource Guide. American Diabetes Association (2005).
- ↑ Hanas, Ragnar (1999). Insulin-Dependent Diabetes-Page 10. ChildrenWithDiabetes.
- ↑ Insulin Producers vs Doctors Re:Combining R/Neutral & Lente-type Insulins. Endotext.com.
- ↑ Huffman DM, Garber AJ.. Availability of Soluble (R/Neutral) Insulin in Mixed Preparations of Crystalline (Lente) & Ultralente GE Insulins. Clinical Therapeutics.
- ↑ Bilo HJ, Heine RJ, Sikkenk AC, van der Meer J, van der Veen EA. (1987). Absorption Kinetics & Action Profiles-Single Subcutaneous Administration of Human Soluble (R/Neutral) & Lente Insulin. Diabetes Care.
- ↑ Heine RJ, Sikkenk AC, Eizenga WH, van der Veen EA. (1983). Delayed Onset of Action of Soluble (R/Neutral) Insulin After Premixing With Lente Insulin Diabetes. Research & Clinical Practice.
- ↑ Insulin Therapy-Mixing Precautions. RxEd.org.
- ↑ Phenol Preservatives & Lente-type Insulins--A Bad Combination. National Federation for the Blind.
- ↑ Lente-Type Insulins & NPH/Isophane Insulins-A Bad Combination. National Federation for the Blind.
- ↑ Insulin Therapy-Mixing Precautions. RxEd.org.
- ↑ Insulin Therapy-Mixing Precautions. RxEd.org.
- ↑ Iletin I Lente-Beef/Pork Insulin Shown at Right.
- ↑ Carton Image-Iletin II Lente.
More Information
- NACDS-Insulin Chart-Page 2
- Insulin therapy for dogs and cats-Dowling-Canadian Veterinary Journal-September 1995
A discussion of Iletin insulins.