Canine Diabetes Wiki
Hypurin Vet Neutral
R, Neutral by CP Pharma
U100 none
Action in dogs:
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h
Line: Hypurin
Also known as: Hypurin Bovine Neutral, Beef R, beef neutral
Similar to: Insuvet Neutral, Betasint Bovine Corriente
Iletin R
Use and Handling:
Shelf Life: 36 months Type: soluble, clear
When Opened: 28 days room temp.
In Pen: N/A
Notes: Protect from light and heat
Do Not Freeze,
May be used intravenously
See Insuvet Neutral, Hypurin Bovine Neutral or
Betasint Bovine Corriente for current handling information for beef R/neutral insulin.
Cp wockhardt bovine insulins

Hypurin Bovine insulins-Bovine Neutral is at far left with a red cap.

Hypurin Vet Neutral was a beef-based short-acting insulin made by CP Pharma[1][2] which has had nothing added to change its speed or length of activity.

It was approved only for veterinary use and for distribution within the UK --the human-approved equivalent which is still available is Hypurin Bovine Neutral. Insuvet Neutral was another comparable veterinary insulin (also UK only), but it has also been discontinued. [3][4][5][6]

It was also equivalent to the former pure bovine Lilly insulin, Iletin I R and to Betasint Bovine Corriente of Beta Laboratorios.

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [7] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [8]

The very small insulin particles in semilente insulin are suspended by zinc. [7] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins [9][10] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [7]

R/Neutral Insulins[]


  1. Patient Information-Hypurin Bovine Neutral. Net
  2. Hypurin Bovine Neutral. Wockhardt UK.
  3. Discontinuation of Insuvet Insulins. My Online Vet UK.
  4. Insuvet Discontinuation. VioVet UK.
  5. Pfizer insulin products currently unavailable. Veterinary News (29 October 2010).
  6. Prescribing Bovine Insulin.
  7. 7.0 7.1 7.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content
  8. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  9. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins.
  10. Resource Guide. American Diabetes Association (2005).

Related pages
Lilly human insulins1992charts
Cp wockhardt bovine insulins
89 main
Betasint Bovine Corriente
Iletin R
Hypurin Bovine Neutral
Insuvet Neutral