| Hypurin Vet Neutral | |
|---|---|
| R, Neutral by CP Pharma | |
| short-acting | |
| Bovine | |
| U100 | none |
Action in dogs:
| |
| Line: Hypurin | |
| Also known as: Hypurin Bovine Neutral, Beef R, beef neutral | |
| Similar to: Insuvet Neutral, Betasint Bovine Corriente Iletin R | |
| Use and Handling: | |
| Shelf Life: 36 months | Type: soluble, clear |
| When Opened: 28 days room temp. | |
| In Pen: N/A | |
| Notes: Protect from light and heat Do Not Freeze, May be used intravenously See Insuvet Neutral, Hypurin Bovine Neutral or Betasint Bovine Corriente for current handling information for beef R/neutral insulin. | |
Hypurin Bovine insulins-Bovine Neutral is at far left with a red cap.
Hypurin Vet Neutral was a beef-based short-acting insulin made by CP Pharma, [1][2] which has had nothing added to change its speed or length of activity.
It was approved only for veterinary use and for distribution within the UK --the human-approved equivalent which is still available is Hypurin Bovine Neutral. Insuvet Neutral was another comparable veterinary insulin (also UK only), but it has also been discontinued. [3][4][5][6]
It was also equivalent to the former pure bovine Lilly insulin, Iletin I R and to Betasint Bovine Corriente of Beta Laboratorios.
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [7] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [8]
The very small insulin particles in semilente insulin are suspended by zinc. [7] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins [9][10] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [7]
R/Neutral Insulins[]
|
R/Neutral Insulins | |
|---|---|
|
All Short acting All soluble |
| Hypurin Bovine Neutral Betasint Bovine Corriente | |
| Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) Insuvet Neutral (No longer produced.) | |
| Iletin I R (No longer produced.) | |
| Hypurin Porcine Neutral Hypurin Pork Regular Betasint Porcine Corriente, Maxirapid CHO | |
| Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) | |
| Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, Umuline Rapide Umuline Regular, Winthrop Rapid Humulin ReliOn R | |
| R-DNA | ReliOn/Novolin R (No longer produced.) |
References[]
- ↑ Patient Information-Hypurin Bovine Neutral. Net Doctor.uk.
- ↑ Hypurin Bovine Neutral. Wockhardt UK.
- ↑ Discontinuation of Insuvet Insulins. My Online Vet UK.
- ↑ Insuvet Discontinuation. VioVet UK.
- ↑ Pfizer insulin products currently unavailable. Veterinary News (29 October 2010).
- ↑ Prescribing Bovine Insulin.
- ↑ 7.0 7.1 7.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid
<ref>tag; name "Auburn" defined multiple times with different content - ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins. - ↑ Resource Guide. American Diabetes Association (2005).
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