Canine Diabetes Wiki
Hypurin Porcine Neutral
R, Neutral by CP Pharma
U100 none
Action in dogs:
  • onset 30-60 minutes,
  • peak 2-4h,
  • duration 6-8h
Line: Hypurin
Also known as: Hypurin Pork Regular, Pork R, pork neutral
Similar to: Betasint Porcine Corriente
Maxirapid CHO, Iletin II R, Leo Neutral,[1] Pork Actrapid


Use and Handling:
Shelf Life: 36 months Type: soluble, clear
When Opened: 6 weeks room temp.
In Pen: 6 weeks room temp.
Notes: Protect from light and heat
Do Not Freeze,
Cartridges in use are not to be refrigerated
May be used intravenously
May be used intramuscularly
Hypurin pork r

Hypurin Porcine R/Neutral as sold in Canada. This insulin is called Hypurin Porcine Neutral elsewhere.

Hypurin Porcine Neutral or Hypurin Pork Regular (Canadian brand name) is a pork-based short-acting insulin made by CP Pharma. [3]

Eli Lilly's Iletin II R [4] was comparable; Novo Nordisk's Pork Actrapid [5][6][7][8] was discontinued at the end of December 2007. [9]

Other comparable insulins in current production are Betasint Porcine Corriente and Maxirapid CHO.

As with all R/neutral insulins, regardless of species, nothing has been added to alter the speed or action of the insulin. [10][11]

Health Canada has approved this insulin, along with another pork product, Hypurin Porcine Isophane, known as Hypurin Pork Isophane or Hypurin Pork NPH in Canada. Both are currently available on the Canadian market without importation. [12] See wiki's CP Pharma page for more information regarding their Canadian availability.

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [13] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [14]

The very small insulin particles in semilente insulin are suspended by zinc. [13] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins.  [15][16] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [13]

R/Neutral Insulins[]


  1. Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  2. Response to Withdrawal of Novo Porcine Insulin Range. CP/Wockhardt UK.
  3. Hypurin Porcine Neutral. Wockhardt UK.
  4. Iletin II R Discontinuation Notice. US Food and Drug Administration (July 2005).
  5. Pork Actrapid Patient Information. Net
  6. Patient Information Leaflet-Pork Actrapid. Novo Nordisk.
  7. Prescribing Porcine Insulin.
  8. Prescribing Novo Animal Insulin.
  9. Pork Actrapid Discontinuation Notice. Novo Nordisk.
  10. Hypurin Porcine Neutral Patient Information. Net
  11. Humulin R. Eli Lilly.
  12. Hypurin Pork Canadian Information. IDDT International.
  13. 13.0 13.1 13.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content
  14. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  15. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  16. Resource Guide. American Diabetes Association (2005).

More Information[]

Related pages
Pork Actrapid
Insulinum Maxrapid 400px
Betasint Porcine Corriente
Iletin II R
Pork Actrapid
Maxirapid CHO