Canine Diabetes Wiki
Hypurin Porcine Isophane
NPH/isophane by CP Pharma
U100 isophane
Action in dogs:
  • onset within 2h,
  • peak 6-12h,
  • duration 18-14h
Line: Hypurin
Also known as: Hypurin Pork NPH, pork NPH, pork isophane
Similar to: Betasint Porcine NPH, Pork Insulatard, [1] Iletin II NPH, Leo Retard [2]
Use and Handling:
Shelf Life: 36 months Type: cloudy
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat
Do Not Freeze, Re-suspend
Do not use if product does not re-suspend

Cartridges in use are not to be refrigerated
Do not use intravenously [3]
May be used intramuscularly, which means onset, peak and duration times are shorter.

Hypurin pork n

Hypurin Pork NPH as sold in Canada. The same insulin is known as Hypurin Porcine Isophane elsewhere.

CP Pharma has two brand names for their pork NPH/isophane insulin [4][5] Hypurin Pork Isophane and Hypurin Pork NPH (Canadian brand name), which is comparable to Betasint Porcine NPH, to Iletin II NPH, [6] formerly produced by Eli Lilly and Pork Insulatard [7][8][9] by Novo Nordisk. [10][11] An intermediate-acting insulin.

Health Canada has approved this insulin and Hypurin Porcine Neutral also known as Hypurin Pork Regular; it is currently available in Canada without importation. [12] The CP Pharma page has more details about availability.

Specifications of NPH/isophane insulin[]

British National Formulary [13] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.

British Pharmacoepia and United States Pharmacopia definitions: [13]

Isophane Insulin

Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.

USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.

NPH/isophane insulins[]

The following commercial insulins are all generically NPH insulins:

Other commonly used names are:

  • NPH insulin, NPH
  • isophane insulin


  1. 1.0 1.1 1.2 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
  2. Montgomery, D. A. D.. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  3. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  4. Hypurin Porcine Isophane Patient Information. Net
  5. Hypurin Porcine Isophane. Wockhardt UK.
  6. Iletin II N Discontinuation Notice. US Food and Drug Administration (July 2005).
  7. Pork Insulatard patient Information. Net
  8. 8.0 8.1 Pork Insulatard. Novo Nordisk. Cite error: Invalid <ref> tag; name "Insulatard" defined multiple times with different content
  9. Pork Insulatard Discontinuation Notice. Novo Nordisk.
  10. 10.0 10.1 Prescribing Porcine Insulin.
  11. 11.0 11.1 Prescribing Novo Animal Insulin.
  12. Hypurin Pork Canadian Information. IDDT International.
  13. 13.0 13.1 British National Formulary-Isophane/NPH Insulin Definition. InChem. Cite error: Invalid <ref> tag; name "InChem" defined multiple times with different content
  14. Hypurin Bovine Isophane Patient Information. Net Doctor uk..
  15. Hypurin Bovine Isophane. Wockhardt UK.
  16. Prescribing Bovine Insulin.

More Information[]

Related Pages
Pork Insulatard
Iletin II N
Betasint Porcine NPH
Pork Insulatard