| Hypurin Porcine Isophane | |
|---|---|
| NPH/isophane by CP Pharma | |
| intermediate-acting | |
| Porcine | |
| U100 | isophane |
Action in dogs:
| |
| Line: Hypurin | |
| Also known as: Hypurin Pork NPH, pork NPH, pork isophane | |
| Similar to: Betasint Porcine NPH, Pork Insulatard, [1] Iletin II NPH, Leo Retard [2] | |
| Use and Handling: | |
| Shelf Life: 36 months | Type: cloudy |
| When Opened: 28 days room temp. | |
| In Pen: 28 days room temp. | |
| Notes: Protect from light and heat Do Not Freeze, Re-suspend Do not use if product does not re-suspend Cartridges in use are not to be refrigerated | |
Hypurin Pork NPH as sold in Canada. The same insulin is known as Hypurin Porcine Isophane elsewhere.
CP Pharma has two brand names for their pork NPH/isophane insulin [4][5] Hypurin Pork Isophane and Hypurin Pork NPH (Canadian brand name), which is comparable to Betasint Porcine NPH, to Iletin II NPH, [6] formerly produced by Eli Lilly and Pork Insulatard [7][8][9] by Novo Nordisk. [10][11] An intermediate-acting insulin.
Health Canada has approved this insulin and Hypurin Porcine Neutral also known as Hypurin Pork Regular; it is currently available in Canada without importation. [12] The CP Pharma page has more details about availability.
Specifications of NPH/isophane insulin[]
British National Formulary [13] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.
British Pharmacoepia and United States Pharmacopia definitions: [13]
Isophane Insulin
Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.
USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.
NPH/isophane insulins[]
The following commercial insulins are all generically NPH insulins:
|
NPH/Isophane Insulins | |
|---|---|
|
All Intermediate acting |
| Betasint Bovine NPH Hypurin Bovine Isophane [14][15][16] | |
| Iletin NPH
(No longer produced.) | |
| Iletin I NPH
(No longer produced.) | |
| Betasint Porcine NPH Hypurin Porcine Isophane [1][10] Hypurin Pork NPH | |
| Iletin II NPH (No longer produced.) Pork Insulatard [1][11][8] (No longer produced.) Leo Retard (No longer produced.) | |
| Huminsulin Basal, Humulin I Humulin N, Humulin NPH Humulina NPH, Humuline N Humuline NPH, Umuline NPH Humulin ReliOn N | |
| Insuhuman Basal, Insuman Basal Isuhuman Basal, Winthrop Basal | |
| Insulatard, Novolin N Protaphan, Protaphane | |
| ReliOn/Novolin NPH (No longer produced) | |
Other commonly used names are:
- NPH insulin, NPH
- isophane insulin
References[]
- ↑ 1.0 1.1 1.2 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
- ↑ Montgomery, D. A. D.. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Hypurin Porcine Isophane Patient Information. Net Doctor.uk.
- ↑ Hypurin Porcine Isophane. Wockhardt UK.
- ↑ Iletin II N Discontinuation Notice. US Food and Drug Administration (July 2005).
- ↑ Pork Insulatard patient Information. Net Doctor.uk.
- ↑ 8.0 8.1 Pork Insulatard. Novo Nordisk. Cite error: Invalid
<ref>tag; name "Insulatard" defined multiple times with different content - ↑ Pork Insulatard Discontinuation Notice. Novo Nordisk.
- ↑ 10.0 10.1 Prescribing Porcine Insulin.
- ↑ 11.0 11.1 Prescribing Novo Animal Insulin.
- ↑ Hypurin Pork Canadian Information. IDDT International.
- ↑ 13.0 13.1 British National Formulary-Isophane/NPH Insulin Definition. InChem. Cite error: Invalid
<ref>tag; name "InChem" defined multiple times with different content - ↑ Hypurin Bovine Isophane Patient Information. Net Doctor uk..
- ↑ Hypurin Bovine Isophane. Wockhardt UK.
- ↑ Prescribing Bovine Insulin.
More Information[]
- NACDS-Insulin Chart-Page 2
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of Iletin insulins. - Insulin pork isophane (NPH)
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