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Hypurin Porcine Isophane

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Hypurin Porcine Isophane
NPH/isophane by CP Pharma
intermediate-acting
Porcine
U100 isophane
Action in dogs:
  • onset within 2h,
  • peak 6-12h,
  • duration 18-14h
Line: Hypurin
Also known as: Hypurin Pork NPH, pork NPH, pork isophane
Similar to: Betasint Porcine NPH, Pork Insulatard, [1] Iletin II NPH, Leo Retard [2]
Use and Handling:
Shelf Life: 36 months Type: cloudy
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat
Do Not Freeze, Re-suspend
Do not use if product does not re-suspend

Cartridges in use are not to be refrigerated
Do not use intravenously [3]
May be used intramuscularly, which means onset, peak and duration times are shorter.

Hypurin pork n

Hypurin Pork NPH as sold in Canada. The same insulin is known as Hypurin Porcine Isophane elsewhere.


CP Pharma has two brand names for their pork NPH/isophane insulin [4][5] Hypurin Pork Isophane and Hypurin Pork NPH (Canadian brand name), which is comparable to Betasint Porcine NPH, to Iletin II NPH, [6] formerly produced by Eli Lilly and Pork Insulatard [7][8][9] by Novo Nordisk. [10][11] An intermediate-acting insulin.

Health Canada has approved this insulin and Hypurin Porcine Neutral also known as Hypurin Pork Regular; it is currently available in Canada without importation. [12] The CP Pharma page has more details about availability.

Specifications of NPH/isophane insulin[]

British National Formulary [13] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.

British Pharmacoepia and United States Pharmacopia definitions: [13]

Isophane Insulin

Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.

USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.

NPH/isophane insulins[]

The following commercial insulins are all generically NPH insulins:


Other commonly used names are:

  • NPH insulin, NPH
  • isophane insulin

References[]

  1. ↑ 1.0 1.1 1.2 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
  2. ↑ Montgomery, D. A. D.. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  3. ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  4. ↑ Hypurin Porcine Isophane Patient Information. Net Doctor.uk.
  5. ↑ Hypurin Porcine Isophane. Wockhardt UK.
  6. ↑ Iletin II N Discontinuation Notice. US Food and Drug Administration (July 2005).
  7. ↑ Pork Insulatard patient Information. Net Doctor.uk.
  8. ↑ 8.0 8.1 Pork Insulatard. Novo Nordisk. Cite error: Invalid <ref> tag; name "Insulatard" defined multiple times with different content
  9. ↑ Pork Insulatard Discontinuation Notice. Novo Nordisk.
  10. ↑ 10.0 10.1 Prescribing Porcine Insulin.
  11. ↑ 11.0 11.1 Prescribing Novo Animal Insulin.
  12. ↑ Hypurin Pork Canadian Information. IDDT International.
  13. ↑ 13.0 13.1 British National Formulary-Isophane/NPH Insulin Definition. InChem. Cite error: Invalid <ref> tag; name "InChem" defined multiple times with different content
  14. ↑ Hypurin Bovine Isophane Patient Information. Net Doctor uk..
  15. ↑ Hypurin Bovine Isophane. Wockhardt UK.
  16. ↑ Prescribing Bovine Insulin.

More Information[]

Related Pages
Iletin II N
Betasint Porcine NPH
Pork Insulatard
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