| Hypurin Porcine 30/70 Mix | |
|---|---|
| R/Neutral/NPH/Isophane Mix by CP Pharma | |
| intermediate-acting | |
| Porcine | |
| U100 | isophane |
Action in dogs:
| |
| Line: Hypurin | |
| Also known as: | |
| Similar to: Pork Mixtard 30 [1] | |
| Use and Handling: | |
| Shelf Life: 36 months | Type: cloudy |
| When Opened: 6 weeks room temp. | |
| In Pen: 6 weeks room temp. | |
| Notes: Protect from light and heat Do Not Freeze, Re-suspend Do not use if product does not Re-suspend Do not refrigerate in use cartridges Do not use intravenously [2] May be used intramuscularly, which would make onset, peak and duration times shorter. | |
Time activity profile for Hypurin Porcine 30/70.
This is CP Pharma's mixed, intermediate-acting insulin. [3] comprised of 70% porcine NPH/isophane insulin and 30% porcine R/neutral insulin [4]
It is comparable to Pork Mixtard 30 [5][6] made by Novo Nordisk [7][8] which was discontinued at the end of December 2007.[9]
Why Lente doesn't equal 70/30[]
Direct comparison of insulin activity profiles for Lente and 70/30 insulins. The early strong action from the non-suspended R/neutral/normal insulin is seen at the "bump" from hours 0-6.
Let's look at the differences in the two insulins. Lente is comprised of 70 % long-acting Ultralente insulin and 30% short-acting Semilente insulin. So proportions of a long-acting and short-acting insulin are being combined to produce a intermediate-acting insulin. Both Ultralente and Semilente insulin are suspended by adding zinc and the size of their respective insulin crystals. The largest insulin crystals are those of Ultralente, while Semilente contains the smallest, or microcrystals. Simply put, you're combining a long insulin and a short insulin to make an intermediate-acting one.[10]
70/30 insulin starts with 70% NPH/isophane insulin, an intermediate-acting insulin which is suspended by protamine. To that, 30% R/neutral/normal insulin, which is short-acting and soluble, meaning there is no suspension; nothing is added to this insulin to delay its action. In this case, you are taking an intermediate-acting insulin with a suspension and adding to it a short-acting one with no suspension to create an intermediate-acting insulin.
So we have an insulin (Lente), made up of a long-acting and short-acting insulin, both with zinc suspensions, and a mixed insulin (70/30), made from an intermediate-acting protamine suspended insulin and a short-acting one without any suspension. Because of these differences, the insulin action profile for these two insulins is going to be quite different, even though both insulins are classed as intermediate-acting.
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
| Non-Analog Mixed Insulins | ||
|---|---|---|
|
All Intermediate-acting | |
| Insulin Is | Expressed As | Expressed As |
| 10% R/Neutral Insulin 90% NPH/Isophane Insulin |
90/10 | 10/90 |
| 20% R/Neutral Insulin 80% NPH/Isophane Insulin |
80/20 | 20/80 |
| 30% R/Neutral Insulin 80% NPH/Isophane Insulin |
70/30 | 30/70 |
| 40% R/Neutral Insulin 60% NPH/Isophane Insulin |
60/40 | 40/60 |
| 50% R/Neutral Insulin 50% NPH/Isophane Insulin |
50/50 | 50/50 |
References[]
- ↑ Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Hypurin Porcine 30/70 Mix. Wockhardt UK.
- ↑ Hypurin Porcine 30/70 Mix Patient Information. Net Doctor.uk.
- ↑ Pork Mixtard 30 Patient Information. Net Doctor.uk.
- ↑ Patient Information Leaflet-Pork Mixtard 30. Novo Nordisk.
- ↑ Prescribing Porcine Insulin.
- ↑ Prescribing Novo Animal Insulin.
- ↑ Pork Mixtard 30 Discontinuation Notice. Novo Nordisk.
- ↑ Greco, Deborah (2010). Treating Diabetes Mellitus in Dogs and Cats. Western Veterinary Conference.
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