Canine Diabetes Wiki
Hypurin Bovine Neutral
R, Neutral by CP Pharma
U100 none
Action in dogs:
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h
Line: Hypurin
Also known as: Hypurin Vet Neutral, Beef R, beef neutral
Similar to: Insuvet Neutral, Betasint Bovine Corriente
Iletin R
Use and Handling:
Shelf Life: 36 months Type: soluble, clear
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat
Do Not Freeze,
Cartridges in use are not to be refrigerated
May be used intravenously
Cp wockhardt bovine insulins

Hypurin Bovine insulins-Hypurin Bovine Neutral is at left with a red cap.

Hypurin Bovine Neutral [1] is a beef-based short-acting insulin made by CP Pharma, [2][3] which has had nothing added to change its speed or length of activity.

A comparable insulin for veterinary use was Insuvet Neutral, made for Pfizer Animal Health, UK; and Hypurin Vet Neutral. Both are no longer being offered.[4][5][6]

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [7] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [8]

The very small insulin particles in semilente insulin are suspended by zinc. [7] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [9][10] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [7]

R/Neutral Insulins[]


  1. Patient Information-Hypurin Bovine Neutral. Net
  2. Hypurin Bovine Neutral. Wockhardt UK.
  3. Prescribing Bovine Insulin.
  4. Discontinuation of Insuvet Insulins. My Online Vet UK.
  5. Insuvet Discontinuation. VioVet UK.
  6. Pfizer insulin products currently unavailable. Veterinary News (29 October 2010).
  7. 7.0 7.1 7.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content
  8. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  9. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  10. Resource Guide. American Diabetes Association (2005).

Related pages
Lilly human insulins1992charts
89 main
Betasint Bovine Corriente
Iletin R
Insuvet Neutral
Hypurin Vet Neutral