Canine Diabetes Wiki
Hypurin Bovine Isophane
NPH/isophane by CP Pharma
U100 isophane
Action in dogs:
  • onset within 2h,
  • peak 6-12h,
  • duration 18-14h
Line: Hypurin
Also known as: Beef NPH, beef isophane
Similar to: Betasint Bovine NPH, Iletin NPH
Use and Handling:
Shelf Life: 36 months Type: cloudy
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat
Do Not Freeze, Re-suspend
Do not use if product does not re-suspend

Cartridges in use are not to be refrigerated
Do not use intravenously [1]
May be used intramuscularly, which means onset, peak and duration times are shorter.
Store between 2-8C,
May be mixed with Bovine Neutral

Cp wockhardt bovine insulins

Hypurin Bovine insulins-Hypurin Bovine Isophane is at right with a brown cap.

Hypurin Bovine Isophane is a beef-based intermediate-acting insulin made by CP Pharma. [2][3][4]

A comparable product,made by Beta Laboratorios is Betasint Bovine NPH; one formerly made by Eli Lilly was all-beef Iletin I NPH.

Specifications of NPH/isophane insulin[]

British National Formulary [5] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.

British Pharmacoepia and United States Pharmacopia definitions: [5]

Isophane Insulin

Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.

USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.

NPH/isophane insulins[]

The following commercial insulins are all generically NPH insulins:

Other commonly used names are:

  • NPH insulin, NPH
  • isophane insulin


  1. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  2. 2.0 2.1 Hypurin Bovine Isophane Patient Information. Net Cite error: Invalid <ref> tag; name "NetDoctor" defined multiple times with different content
  3. 3.0 3.1 Hypurin Bovine Isophane. Wockhardt UK.
  4. 4.0 4.1 Prescribing Bovine Insulin.
  5. 5.0 5.1 British National Formulary-Isophane/NPH Insulin Definition. InChem. Cite error: Invalid <ref> tag; name "InChem" defined multiple times with different content
  6. 6.0 6.1 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
  7. Prescribing Porcine Insulin.
  8. Prescribing Novo Animal Insulin.
  9. Patient Information Leaflet-Pork Insulatard. Novo Nordisk.

Related pages
Lilly human insulins1992charts
Betasint Bovine NPH
Iletin NPH