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+ | {|class="wikitable" align="right" width="300" bgcolor="powderblue"| |
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− | {{Insulin| |
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+ | ! colspan="2" style="background:#cae1ff; width:300px;font-size:10pt" |Humuline 30/70 |
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− | bgcolor=#d1eeee| |
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+ | |- |
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− | fgcolor=#000080| |
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+ | |colspan="2" style="background:aliceblue; width:300px; text-align:center;font-size:9pt" |[[Mixed insulins|R/Neutral/NPH/Isophane Mix]] by [[Eli Lilly]] |
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− | name=Humuline 30/70| |
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+ | |- |
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− | generic=[[Mixed insulins|R/Neutral/NPH/Isophane Mix]]| |
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+ | | colspan="2" style="background:#bcd2ee; width:300px; text-align:center;font-size:9pt"|[[intermediate-acting]] |
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− | mfg=[[Eli Lilly]]| |
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+ | |- |
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− | |- align="center" style="background:#cae1ff;border-bottom:3px solid grey;"| |
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+ | |colspan="2" style="background:#bcd2ee; width:300px; text-align:center;font-size:9pt"|[[r-DNA/GE/GM]] |
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− | action=[[intermediate-acting]]| |
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+ | |- |
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− | origin=[[r-DNA/GE/GM]]| |
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+ | !colspan="1" style="background:#bcd2ee; width:150px; text-align:center;font-size:9pt" | U40, U100 |
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− | strength=U100| |
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+ | |colspan="1" style="background:#bcd2ee; width:150px;text-align:center;font-size:9pt"|[[isophane]] |
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− | suspension=[[isophane]]| |
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+ | |- |
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− | line=[[Humulin]]| |
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+ | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Action in dogs:''' |
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⚫ | |||
− | similar= |
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⚫ | |||
− | *[[Actraphane 30/70]], |
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− | *[[ReliOn/Novolin 70/30]], |
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⚫ | |||
− | *[[Penmix 30]]<ref>[http://www.medsafe.govt.nz/Profs/DataSheet/PenmixMixtardProtaphaneinj.htm Medsafe NZ Penmix 30]</ref>, |
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− | *[[Novolin 30R]], |
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⚫ | |||
⚫ | |||
− | dogaction= |
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*onset 0.5-3h, |
*onset 0.5-3h, |
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*peak 2-10h, |
*peak 2-10h, |
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− | *duration 4-24h |
+ | *duration 4-24h |
+ | |- |
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− | cloudyorsoluble=[[cloudy]]| |
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+ | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Line:''' [[Humulin]] |
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− | shelflife= 24 months| |
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+ | |- |
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− | openedlife= 28 days room temp.| |
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+ | | colspan="2" style="background:aliceblue; width:300px; font-size:9pt;text-align:left"| '''Also known as:''' [[Huminsulin Profil III]], [[Humulin 3/7]]<br>[[Humulin 30/70]], [[Humulina 30/70]], [[Humulin M3]]<br>[[Profil 30]], [[Umuline Profil 30]], [[Humulin 70/30]]<br>[[Humulin Mix 30/70]], [[Humulin ReliOn 70/30]] |
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− | penlife= 28 days room temp.| |
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+ | |- |
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− | handlingnotes= |
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+ | | colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''Similar to:''' [[Actraphane 30/70]], [[Mixtard 30]], [[Penmix 30]], <br>[[Novolin 70/30]], [[Novolin 30R]], [[ReliOn/Novolin 70/30]]<br> |
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− | *protect from light and heat |
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⚫ | |||
− | *Do Not Freeze |
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+ | <br><br> |
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− | *Do not use if product does not [[re-suspend]] |
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⚫ | |||
− | *[[Rolling insulin|Roll]] |
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+ | |- |
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− | *Do not use [[intravenously]] |
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+ | | colspan="2" style="background:#cae1ff; width:300px;text-align:center;font-size:9pt" | '''Use and Handling:''' |
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⚫ | |||
+ | |- |
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+ | |colspan="1" style="background:aliceblue; width:150px;font-size:9pt;text-align:left"|'''Shelf Life:''' 24 months |
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+ | |colspan="1" style="background:aliceblue; width:150px;font-size:9pt;text-align:left" | '''Type:''' [[cloudy]] |
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⚫ | |||
+ | |- |
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+ | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''When Opened:''' 28 days room temp. |
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+ | |- |
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+ | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''In Pen:''' 28 days room temp. |
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+ | |- |
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+ | | colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''Notes:''' Protect from light and heat<br> Do Not Freeze, [[Resuspending insulin|Resuspend]]<br> Do not use if product does not [[re-suspend]]<br>Do not use [[intravenously]] <ref>{{cite web|title=Small Animal Clinical Pharmacology|author=Maddison, Jill E.,Page, Stephen W.,Church, David B.|year=2008|publisher=Saunders Ltd.|isbn=0702028584|page=510|url=http://www.amazon.com/Animal-Clinical-Pharmacology-Maddison-DipVetClinStud/dp/0702028584/ref=sr_1_1?s=books&ie=UTF8&qid=1296451134&sr=1-1}}</ref> |
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⚫ | |||
+ | [[Image:30 70.jpg|250px|left|thumb|Humulins-Humuline 30/70 time activity profile.]] |
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⚫ | The same insulin is known as [[Humulin 70/30]], [[Humulina 30/70]], [[Humulin M3]]<ref> |
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+ | <br clear=left> |
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⚫ | This is comparable to [[Novolin 70/30]], [[ReliOn/Novolin 70/30]], [[Actraphane 30/70]]<ref> |
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⚫ | |||
⚫ | The same insulin is known as [[Humulin 70/30]], [[Humulina 30/70]], [[Humulin M3]] <ref>{{cite web|url=http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=13403 |title=Patient Information Leaflet-Humulin M3|publisher=Eli Lilly}}</ref><ref>{{cite web|url=http://web.archive.org/web/20080613090350/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Humulin_M3.htm|title= Humulin M3 Prescribing Information}}</ref> <ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/1071_LLY_Diabetes_RangeChar.pdf |title=Lilly EU/UK Product Sheet & Time Activity Profiles|publisher=Eli Lilly}}</ref> in the UK,[[Umuline Profil 30]], and [[Huminsulin Profil III]] elsewhere. |
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⚫ | [[Mixed insulins]] cover a wide range as they can be [[:Category:Origin|animal]] origin, [[r-DNA/GE/GM]] origin or [[analog]] insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin. |
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⚫ | This is comparable to [[Novolin 70/30]], [[ReliOn/Novolin 70/30]], [[Actraphane 30/70]], <ref>{{cite web|url=http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Novo_insulins.htm |title=Prescribing Novo Insulins}}</ref> and [[Mixtard 30]]. <ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000428/WC500029819.pdf|title=Scientific Discussion-Mixtard|publisher=EMEA}}</ref><ref>{{cite web|url=http://www.leedsth.nhs.uk/sites/diabetes/information/InsulinMixtures.php |title=Insulins & Mixtures|publisher=NHS}}</ref><ref>{{cite web|url=http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=15974 |title=Patient Information leaflet-Mixtard 30|publisher=Novo Nordisk}}</ref> It's also similar to [[Winthrop Comb 30]] and [[Insuman Comb 30]] by [[Aventis]]. All are mixed, intermediate-acting, 70% NPH/isophane crystal <ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000427/WC500025430.pdf|title=Scientific Discussion--Actraphane|publisher=EMEA}}</ref> insulin with 30% R/neutral insulin. |
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⚫ | For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70 |
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+ | |||
+ | ==Why Lente doesn't equal 70/30== |
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+ | [[Image:Lente-70 30.jpg|300px|left|thumb|Direct comparison of insulin activity profiles for Lente and 70/30 insulins. The early strong action from the non-suspended R/neutral/normal insulin is seen at the "bump" from hours 0-6.]] |
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+ | |||
+ | <br clear=left> |
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+ | Let's look at the differences in the two insulins. Lente is comprised of 70 % [[:Category:Long-acting|long-acting]] [[Ultralente]] insulin and 30% [[:Category:Short-acting|short-acting]] [[Semilente]] insulin. So proportions of a long-acting and short-acting insulin are being combined to produce a [[:Category:Intermediate-acting|intermediate-acting]] insulin. Both Ultralente and Semilente insulin are [[suspension|suspended]] by adding [[:Category:Zinc|zinc]] and the size of their respective insulin crystals. The largest insulin crystals are those of Ultralente, while Semilente contains the smallest, or microcrystals. Simply put, you're combining a long insulin and a short insulin to make an intermediate-acting one.<ref>{{cite web|url=http://images1.wikia.nocookie.net/diabetesindogs/images/4/42/2010_T35-greco-western-2010.pdf|title=Treating Diabetes Mellitus in Dogs and Cats|author=Greco, Deborah|publisher=Western Veterinary Conference|year=2010}}</ref> |
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+ | |||
+ | 70/30 insulin starts with 70% [[NPH]]/isophane insulin, an [[:Category:Intermediate-acting|intermediate-acting]] insulin which is suspended by [[Protamine|protamine]]. To that, 30% [[R]]/neutral/normal insulin, which is [[:Category:Short-acting|short-acting]] and [[Soluble insulin|soluble]], meaning there is no suspension; nothing is added to this insulin to delay its action. In this case, you are taking an intermediate-acting insulin with a suspension and adding to it a short-acting one with no suspension to create an intermediate-acting insulin. |
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+ | |||
+ | So we have an insulin ([[:Category:Lente|Lente]]), made up of a long-acting and short-acting insulin, both with [[:Category:Zinc|zinc]] suspensions, and a [[:Category:Mixed|mixed]] insulin (70/30), made from an intermediate-acting [[:Category:Isophane|protamine]] suspended insulin and a short-acting one without any suspension. Because of these differences, the insulin action profile for these two insulins is going to be quite different, even though both insulins are classed as intermediate-acting. |
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+ | |||
⚫ | [[Mixed insulins]] cover a wide range as they can be [[:Category:Origin|animal]] origin, [[r-DNA/GE/GM]] origin or [[analog]] insulins. The non-analog mixed insulins are made up of [[:Category:Intermediate-acting|intermediate-acting]] [[NPH]]/isophane insulin and [[:Category:Short-acting|short-acting]] [[R]]/neutral. normal insulin. The analog mixes are made from [[:Category:Intermediate-acting|intermediate-acting]] protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and [[:Category:Fast-acting|fast-acting]] analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin. |
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+ | |||
⚫ | For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin. |
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The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork [[Iletin]] and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion: |
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork [[Iletin]] and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion: |
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− | {| align="center" width="500" border="1" bgcolor="powderblue"| |
+ | {| class="collapsible collapsed" align="center" width="500" border="1" bgcolor="powderblue"| |
− | ! bgcolor=" |
+ | ! bgcolor="BCD2EE" colspan="3" |Non-Analog Mixed Insulins |
|- |
|- |
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! bgcolor="lightcyan" width="200" |[[Image:Intermediate_acting.jpg|200px]] |
! bgcolor="lightcyan" width="200" |[[Image:Intermediate_acting.jpg|200px]] |
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− | ! bgcolor=" |
+ | ! bgcolor="#cae1ff" colspan="2" |All [[Intermediate-acting]] |
− | | |
+ | |- |
− | + | ! colspan="1" bgcolor="aliceblue"|Insulin Is |
|
! colspan="1" bgcolor="aliceblue"| Expressed As |
! colspan="1" bgcolor="aliceblue"| Expressed As |
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!colspan="1" bgcolor="aliceblue"|Expressed As |
!colspan="1" bgcolor="aliceblue"|Expressed As |
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|- |
|- |
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⚫ | |||
! colspan="1" bgcolor="ivory"|10/90 |
! colspan="1" bgcolor="ivory"|10/90 |
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|- |
|- |
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! colspan="1" bgcolor="ivory"|20% [[R|R/Neutral Insulin]]<br />80% [[NPH|NPH/Isophane Insulin]] |
! colspan="1" bgcolor="ivory"|20% [[R|R/Neutral Insulin]]<br />80% [[NPH|NPH/Isophane Insulin]] |
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⚫ | |||
⚫ | |||
|- |
|- |
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− | ! colspan="1" bgcolor="ivory"|30/ |
+ | ! colspan="1" bgcolor="ivory"|30% [[R|R/Neutral Insulin]]<br />80% [[NPH|NPH/Isophane Insulin]] |
!colspan="1" bgcolor="ivory"|70/30 |
!colspan="1" bgcolor="ivory"|70/30 |
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− | ! colspan="1" bgcolor="ivory"|30 |
+ | ! colspan="1" bgcolor="ivory"|30/70 |
|- |
|- |
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− | ! colspan="1" bgcolor="ivory"|40/60 |
+ | ! colspan="1" bgcolor="ivory"|40% [[R|R/Neutral Insulin]]<br />60% [[NPH|NPH/Isophane Insulin]] |
! colspan="1" bgcolor="ivory"|60/40 |
! colspan="1" bgcolor="ivory"|60/40 |
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− | ! colspan="1" bgcolor="ivory"|40 |
+ | ! colspan="1" bgcolor="ivory"|40/60 |
|- |
|- |
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⚫ | |||
− | !colspan="1" bgcolor="ivory"|50/50 |
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! colspan="1" bgcolor="ivory"|50% [[R|R/Neutral Insulin]]<br />50% [[NPH|NPH/Isophane Insulin]] |
! colspan="1" bgcolor="ivory"|50% [[R|R/Neutral Insulin]]<br />50% [[NPH|NPH/Isophane Insulin]] |
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⚫ | |||
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|} |
|} |
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− | |||
⚫ | |||
− | <references/> |
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⚫ | |||
+ | {{Reflist|colwidth=30em}} |
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==More Information== |
==More Information== |
||
− | *[http:// |
+ | *[http://images2.wikia.nocookie.net/__cb20100821055615/diabetesindogs/images/0/0a/NACDS_insulin_chart.pdf NACDS-Insulin Chart-Page 2] |
*[http://www.leedsth.nhs.uk/sites/diabetes/insular/InsulinGuide.php Leeds NHS UK Insulin Guide] |
*[http://www.leedsth.nhs.uk/sites/diabetes/insular/InsulinGuide.php Leeds NHS UK Insulin Guide] |
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<br clear=left/> |
<br clear=left/> |
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+ | |||
+ | <center>'''Related pages'''</center> |
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+ | {|align="center" width="600" |
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+ | |||
+ | |<center>[[Image:NVN18370 73077 5.jpg|100px]]</center> |
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+ | |<center>[[Image:Mixtard30.jpg|100px]]</center> |
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+ | |<center>[[Image:HumilinLILLY.jpg|100px]]</center> |
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+ | |<center>[[Image:21941f.png|100px]]</center> |
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+ | |<center>[[Image:30 70.jpg|100px]]</center> |
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+ | |||
+ | |- |
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⚫ | |||
⚫ | |||
+ | |<center>[[Humulin 70/30]]</center> |
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+ | |<center>[[Humulin M3]]</center> |
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⚫ | |||
+ | |} |
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+ | [[Category:30-70]] |
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[[Category:Content]] |
[[Category:Content]] |
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[[Category:Insulins]] |
[[Category:Insulins]] |
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[[Category:Eli Lilly]] |
[[Category:Eli Lilly]] |
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[[Category:R-DNA/GE/GM]] |
[[Category:R-DNA/GE/GM]] |
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+ | [[Category:Currently marketed insulins]] |
Latest revision as of 23:24, 23 May 2012
Humuline 30/70 | |
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R/Neutral/NPH/Isophane Mix by Eli Lilly | |
intermediate-acting | |
r-DNA/GE/GM | |
U40, U100 | isophane |
Action in dogs:
| |
Line: Humulin | |
Also known as: Huminsulin Profil III, Humulin 3/7 Humulin 30/70, Humulina 30/70, Humulin M3 Profil 30, Umuline Profil 30, Humulin 70/30 Humulin Mix 30/70, Humulin ReliOn 70/30 | |
Similar to: Actraphane 30/70, Mixtard 30, Penmix 30, Novolin 70/30, Novolin 30R, ReliOn/Novolin 70/30 Insuman Comb 30, Winthrop Comb 30
| |
Use and Handling: | |
Shelf Life: 24 months | Type: cloudy |
When Opened: 28 days room temp. | |
In Pen: 28 days room temp. | |
Notes: Protect from light and heat Do Not Freeze, Resuspend Do not use if product does not re-suspend Do not use intravenously [1] |
Humuline 30/70 is a mixed insulin made by Eli Lilly [2].
The same insulin is known as Humulin 70/30, Humulina 30/70, Humulin M3 [3][4] [5] in the UK,Umuline Profil 30, and Huminsulin Profil III elsewhere.
This is comparable to Novolin 70/30, ReliOn/Novolin 70/30, Actraphane 30/70, [6] and Mixtard 30. [7][8][9] It's also similar to Winthrop Comb 30 and Insuman Comb 30 by Aventis. All are mixed, intermediate-acting, 70% NPH/isophane crystal [10] insulin with 30% R/neutral insulin.
Why Lente doesn't equal 70/30[]
Let's look at the differences in the two insulins. Lente is comprised of 70 % long-acting Ultralente insulin and 30% short-acting Semilente insulin. So proportions of a long-acting and short-acting insulin are being combined to produce a intermediate-acting insulin. Both Ultralente and Semilente insulin are suspended by adding zinc and the size of their respective insulin crystals. The largest insulin crystals are those of Ultralente, while Semilente contains the smallest, or microcrystals. Simply put, you're combining a long insulin and a short insulin to make an intermediate-acting one.[11]
70/30 insulin starts with 70% NPH/isophane insulin, an intermediate-acting insulin which is suspended by protamine. To that, 30% R/neutral/normal insulin, which is short-acting and soluble, meaning there is no suspension; nothing is added to this insulin to delay its action. In this case, you are taking an intermediate-acting insulin with a suspension and adding to it a short-acting one with no suspension to create an intermediate-acting insulin.
So we have an insulin (Lente), made up of a long-acting and short-acting insulin, both with zinc suspensions, and a mixed insulin (70/30), made from an intermediate-acting protamine suspended insulin and a short-acting one without any suspension. Because of these differences, the insulin action profile for these two insulins is going to be quite different, even though both insulins are classed as intermediate-acting.
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
Non-Analog Mixed Insulins | ||
---|---|---|
All Intermediate-acting | ||
Insulin Is | Expressed As | Expressed As |
10% R/Neutral Insulin 90% NPH/Isophane Insulin |
90/10 | 10/90 |
20% R/Neutral Insulin 80% NPH/Isophane Insulin |
80/20 | 20/80 |
30% R/Neutral Insulin 80% NPH/Isophane Insulin |
70/30 | 30/70 |
40% R/Neutral Insulin 60% NPH/Isophane Insulin |
60/40 | 40/60 |
50% R/Neutral Insulin 50% NPH/Isophane Insulin |
50/50 | 50/50 |
References[]
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Humulin 70/30-NPH;R Human Insulin. Revolution Health.
- ↑ Patient Information Leaflet-Humulin M3. Eli Lilly.
- ↑ Humulin M3 Prescribing Information.
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Prescribing Novo Insulins.
- ↑ Scientific Discussion-Mixtard. EMEA.
- ↑ Insulins & Mixtures. NHS.
- ↑ Patient Information leaflet-Mixtard 30. Novo Nordisk.
- ↑ Scientific Discussion--Actraphane. EMEA.
- ↑ Greco, Deborah (2010). Treating Diabetes Mellitus in Dogs and Cats. Western Veterinary Conference.
More Information[]