Humuline 30/70

Humuline 30/70
R/Neutral/NPH/Isophane Mix by Eli Lilly
intermediate-acting	r-DNA/GE/GM
U100	isophane
Line	Humulin
Also known as	Huminsulin Profil III, Humulin 3/7, Humulin 30/70, Humulin 70/30,Humulin M3, Humulin Mix 30/70,Humulina 30/70, Profil 30, Umuline Profil 30 Names of Lilly r-DNA/GE/GM insulins worldwide
Similar to	Actraphane 30/70 Insuman Comb 30 Mixtard 30 Novolin 30R Novolin 70/30 Penmix 30 ReliOn/Novolin 70/30 Winthrop Comb 30
Action in dogs	onset 0.5-3h, peak 2-10h, duration 4-24h
Use and Handling
Type	cloudy
Shelf Life	24 months
When opened	28 days room temp.
In pen	28 days room temp.
Notes	protect from light and heat Do Not Freeze Do not use if product does not re-suspend Roll Do not use intravenously

Humulins-Humulina 30/70 time activity profile.

Humuline 30/70 is a mixed insulin made by Eli Lilly.

The same insulin is known as Humulin 70/30, Humulina 30/70, Humulin M3 in the UK,Umuline Profil 30, and Huminsulin Profil III elsewhere.

This is comparable to Novolin 70/30, ReliOn/Novolin 70/30, Actraphane 30/70, and Mixtard 30. It's also similar to Winthrop Comb 30 and Insuman Comb 30 by Aventis. All are mixed, intermediate-acting, 70% NPH/isophane crystal insulin with 30% R/neutral insulin.

Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.

For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.

The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:

Non-Analog Mixed Insulins
	All Intermediate-acting

Expressed As	Expressed As	Insulin Is
10/90	90/10	10% R/Neutral Insulin 90% NPH/Isophane Insulin
20/80	80/20	20% R/Neutral Insulin 80% NPH/Isophane Insulin
30/70	70/30	30% R/Neutral Insulin 70% NPH/Isophane Insulin
40/60	60/40	40% R/Neutral Insulin 60% NPH/Isophane Insulin
50/50	50/50	50% R/Neutral Insulin 50% NPH/Isophane Insulin

More Information

• NACDS-Insulin Chart-Page 2
• Leeds NHS UK Insulin Guide