Changes: Humulina 40/60

Revision as of 18:35, 4 January 2011

Humulina 40/60
R/Neutral/NPH/Isophane Mix by Eli Lilly
intermediate-acting
r-DNA/GE/GM
U40, U100	isophane
Action in dogs: onset 0.5-3h, peak 2-10h, duration 4-24h
Line: Humulin
Also known as: Huminsulin Profil IV, Humulin 40/60, Humuline 40/60, Humulin M4, Umuline Profil 40 Profil 40
Similar to: Actraphane 40/60, Mixtard 40, Penmix 40 ^[1] Names of Lilly r-DNA/GE/GM insulins worldwide
Use and Handling:
Shelf Life: 24 months	Type: cloudy
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat Do Not Freeze, Resuspend Do not use if product does not re-suspend Do not use intravenously

Time activity profile for 40/60 insulin.

An intermediate-acting, mixed insulin like Humulin 40/60, Huminsulin Profil IV, Humuline 40/60, Humulin M4, Penmix 40 and Mixtard 40 ^[2] of 40% R/neutral insulin and 60% NPH/isophane insulin^[3] made by Eli Lilly. Humulina 40/60, like Mixtard 40, ^[4] contains 60% isophane insulin crystals.

Mixtard 40 was discontinued December 31, 2007. ^[5]^[6] Humulin 40/60 is also no longer available.

Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.

For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.

The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:

Non-Analog Mixed Insulins
	All Intermediate-acting
Insulin Is	Expressed As	Expressed As
10% R/Neutral Insulin 90% NPH/Isophane Insulin	90/10	10/90
20% R/Neutral Insulin 80% NPH/Isophane Insulin	80/20	20/80
30% R/Neutral Insulin 80% NPH/Isophane Insulin	70/30	30/70
40% R/Neutral Insulin 60% NPH/Isophane Insulin	60/40	40/60
50% R/Neutral Insulin 50% NPH/Isophane Insulin	50/50	50/50

References

↑ Penmix 40. Medsafe NZ.
↑ Prescribing Novo Insulins.
↑ Humulin 40/60. Rxmed.com.
↑ Scientific Discussion-Mixtard. EMEA.
↑ Insulin Discontinuations-UK. NHS.
↑ Chart of Discontinued Novo Human Insulins. Novo Nordisk.

Related pages


Humulin M4	Mixtard 40	Humulin 40/60	Penmix 40

[1] Penmix 40. Medsafe NZ.

[2] Prescribing Novo Insulins.

[3] Humulin 40/60. Rxmed.com.

[4] Scientific Discussion-Mixtard. EMEA.

[5] Insulin Discontinuations-UK. NHS.

[6] Chart of Discontinued Novo Human Insulins. Novo Nordisk.

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-An intermediate-acting, mixed insulin like [[Humulin 40/60]], [[Huminsulin Profil IV]], [[Humuline 40/60]], [[Humulin M4]], [[Penmix 40]] and [[Mixtard 40]] <ref>{{cite web|url=http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Novo_insulins.htm |title=Prescribing Novo Insulins}}</ref> of 40% R/neutral insulin and 60% NPH/isophane insulin<ref>{{cite web|url=http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20H)/HUMULIN.html|title=Humulin 40/60|publisher=Rxmed.com}}</ref> made by [[Eli Lilly]]. Humulina 40/60, like [[Mixtard 40]] <ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000428/WC500029819.pdf|title=Scientific Discussion-Mixtard|publisher=EMEA}}</ref> contains 60% [[isophane]] insulin crystals.
+An intermediate-acting, mixed insulin like [[Humulin 40/60]], [[Huminsulin Profil IV]], [[Humuline 40/60]], [[Humulin M4]], [[Penmix 40]] and [[Mixtard 40]] <ref>{{cite web|url=http://web.archive.org/web/20080208084240/http://www.drgc.cwc.net/Care_pathway/Patient_information/Insulin/Novo_insulins.htm |title=Prescribing Novo Insulins}}</ref> of 40% R/neutral insulin and 60% NPH/isophane insulin<ref>{{cite web|url=http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20H)/HUMULIN.html|title=Humulin 40/60|publisher=Rxmed.com}}</ref> made by [[Eli Lilly]]. Humulina 40/60, like [[Mixtard 40]], <ref>{{cite web|url=http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000428/WC500029819.pdf|title=Scientific Discussion-Mixtard|publisher=EMEA}}</ref> contains 60% [[isophane]] insulin crystals.
 Mixtard 40 was discontinued December 31, 2007. <ref>{{cite web|url=http://www.ukmicentral.nhs.uk/therapeu/pace/PACE0604.pdf |title=Insulin Discontinuations-UK|publisher=NHS}}</ref><ref>{{cite web|url=http://www.yorkshirediabetes.com/downloads/A4Humandis.pdf |title=Chart of Discontinued Novo Human Insulins|publisher=Novo Nordisk}}</ref> Humulin 40/60 is also no longer available.