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| + | {|class="wikitable" align="right" width="300" bgcolor="powderblue"| |
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| − | {{Insulin| |
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| + | ! colspan="2" style="background:#cae1ff; width:300px;font-size:10pt" | Humulina 40/60 |
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| − | bgcolor=#cae1ff| |
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| + | |- |
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| − | fgcolor=#000080| |
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| + | |colspan="2" style="background:aliceblue; width:300px; text-align:center;font-size:9pt" |[[Mixed insulins|R/Neutral/NPH/Isophane Mix]] by [[Eli Lilly]] |
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| − | name=Humulina 40/60| |
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| + | |- |
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| − | generic=[[Mixed insulins|R/Neutral/NPH/Isophane Mix]]| |
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| + | |colspan="2" style="background:#bcd2ee; width:300px; text-align:center;font-size:9pt"|[[intermediate-acting]] |
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| − | mfg=[[Eli Lilly]]| |
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| + | |- |
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| − | action=[[intermediate-acting]]| |
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| + | |colspan="2" style="background:#bcd2ee; width:300px; text-align:center;font-size:9pt"|[[r-DNA/GE/GM]] |
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| − | origin=[[r-DNA/GE/GM]]| |
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| + | |- |
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| − | strength=U100| |
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| + | ! colspan="1" style="background:#bcd2ee; width:150px; text-align:center;font-size:9pt" | U40, U100 |
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| − | suspension=[[isophane]]| |
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| + | |colspan="1" style="background:#bcd2ee; width:150px;text-align:center;font-size:9pt"|[[isophane]] |
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| − | line=[[Humulin]]| |
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| + | |- |
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| − | aliases=[[Huminsulin Profil IV]], [[Humulin 40/60]], [[Humulin 60/40]], [[Humulin M4]], [[Humuline 40/60]], [[Profil 40]], [[Umuline Profil 40]] |
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| + | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Action in dogs:''' |
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| − | |||
| − | <br>[http://images3.wikia.nocookie.net/__cb20100602042136/diabetesindogs/images/2/23/WW_Humuline.pdf Names of Lilly r-DNA/GE/GM insulins worldwide]| |
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| − | similar= |
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| − | *[[Actraphane 40/60]] |
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| − | *[[Mixtard 40]] |
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| − | *[[Penmix 40]] <ref>{{cite web|url=http://www.medsafe.govt.nz/Profs/DataSheet/PenmixMixtardProtaphaneinj.htm |title=Penmix 40|publisher=Medsafe NZ}}</ref>| |
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| − | dogaction= |
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*onset 0.5-3h, |
*onset 0.5-3h, |
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*peak 2-10h, |
*peak 2-10h, |
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| − | *duration 4-24h |
+ | *duration 4-24h |
| + | |- |
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| − | cloudyorsoluble=[[cloudy]]| |
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| + | | colspan="2" style="background:aliceblue; width:300px;font-size:9pt; text-align:left" | '''Line:''' [[Humulin]] |
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| − | shelflife= 30 months| |
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| + | |- |
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| − | openedlife= 6 weeks room temp.| |
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| + | | colspan="2" style="background:aliceblue; width:300px; font-size:9pt;text-align:left"| '''Also known as:''' [[Huminsulin Profil IV]], [[Humulin 40/60]], [[Humuline 40/60]], [[Humulin M4]], [[Umuline Profil 40]]<br>[[Profil 40]] |
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| − | penlife= 6 weeks room temp.| |
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| + | |- |
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| − | handlingnotes= |
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| + | | colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''Similar to:''' [[Actraphane 40/60]], [[Mixtard 40]],<br> [[Penmix 40]] <ref>{{cite web|url=http://www.medsafe.govt.nz/Profs/DataSheet/PenmixMixtardProtaphaneinj.htm |title=Penmix 40|publisher=Medsafe NZ}}</ref><br><br>[http://images3.wikia.nocookie.net/__cb20100602042136/diabetesindogs/images/2/23/WW_Humuline.pdf Names of Lilly r-DNA/GE/GM insulins worldwide] |
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| − | *protect from light and heat |
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| + | |- |
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| − | *Do Not Freeze |
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| + | |colspan="2" style="background:#cae1ff; width:300px;text-align:center;font-size:9pt" | '''Use and Handling:''' |
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| − | *Do not use if product does not [[re-suspend]] |
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| + | |- |
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| − | *[[Rolling insulin|Roll]] |
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| + | |colspan="1" style="background:aliceblue; width:150px;font-size:9pt;text-align:left"|'''Shelf Life:''' 24 months |
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| − | *Do not use [[intravenously]] |
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| + | | colspan="1" style="background:aliceblue; width:150px;font-size:9pt;text-align:left" |'''Type:''' [[cloudy]] |
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| − | *Do not refrigerate in use cartridges/pens. |
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| + | |- |
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| ⚫ | |||
| + | | colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''When Opened:''' 28 days room temp. |
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| + | |- |
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| + | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left"| '''In Pen:''' 28 days room temp. |
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| + | |- |
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| + | |colspan="2" style="background:aliceblue; width:300px;font-size:9pt;text-align:left" | '''Notes:''' Protect from light and heat<br> Do Not Freeze, [[Resuspending insulin|Resuspend]]<br> Do not use if product does not [[re-suspend]]<br>Do not use [[intravenously]] |
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| ⚫ | |||
[[Image:40_60.jpg|300px|left|thumb|Time activity profile for 40/60 insulin.]] |
[[Image:40_60.jpg|300px|left|thumb|Time activity profile for 40/60 insulin.]] |
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Revision as of 22:58, 7 October 2010
| Humulina 40/60 | |
|---|---|
| R/Neutral/NPH/Isophane Mix by Eli Lilly | |
| intermediate-acting | |
| r-DNA/GE/GM | |
| U40, U100 | isophane |
Action in dogs:
| |
| Line: Humulin | |
| Also known as: Huminsulin Profil IV, Humulin 40/60, Humuline 40/60, Humulin M4, Umuline Profil 40 Profil 40 | |
| Similar to: Actraphane 40/60, Mixtard 40, Penmix 40 [1] Names of Lilly r-DNA/GE/GM insulins worldwide | |
| Use and Handling: | |
| Shelf Life: 24 months | Type: cloudy |
| When Opened: 28 days room temp. | |
| In Pen: 28 days room temp. | |
| Notes: Protect from light and heat Do Not Freeze, Resuspend Do not use if product does not re-suspend Do not use intravenously | |
Time activity profile for 40/60 insulin.
An intermediate-acting, mixed insulin like Humulin 40/60, Huminsulin Profil IV, Humuline 40/60, Humulin M4, Penmix 40 and Mixtard 40 [2] of 40% R/neutral insulin and 60% NPH/isophane insulin[3] made by Eli Lilly. Humulina 40/60, like Mixtard 40 [4] contains 60% isophane insulin crystals.
Mixtard 40 was discontinued December 31, 2007. [5][6] Humulin 40/60 is also no longer available.
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
| Non-Analog Mixed Insulins | ||
|---|---|---|
|
All Intermediate-acting | |
| Insulin Is | Expressed As | Expressed As |
| 10% R/Neutral Insulin 90% NPH/Isophane Insulin |
90/10 | 10/90 |
| 20% R/Neutral Insulin 80% NPH/Isophane Insulin |
80/20 | 20/80 |
| 30% R/Neutral Insulin 80% NPH/Isophane Insulin |
70/30 | 30/70 |
| 40% R/Neutral Insulin 60% NPH/Isophane Insulin |
60/40 | 40/60 |
| 50% R/Neutral Insulin 50% NPH/Isophane Insulin |
50/50 | 50/50 |
References
- ↑ Penmix 40. Medsafe NZ.
- ↑ Prescribing Novo Insulins.
- ↑ Humulin 40/60. Rxmed.com.
- ↑ Scientific Discussion-Mixtard. EMEA.
- ↑ Insulin Discontinuations-UK. NHS.
- ↑ Chart of Discontinued Novo Human Insulins. Novo Nordisk.