Humulin S | |
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R, Neutral by Eli Lilly | |
short-acting | |
r-DNA/GE/GM | |
U40, U100 | none |
Action in dogs:
| |
Line: Humulin | |
Also known as: Huminsulin Normal Humulin C, Humulin R, Humuline R Humuline Regular, Humulin Regular Humulina Regular, Humulin ReliOn R Umuline Rapide, Umuline Regular | |
Similar to: Insuman Rapid, Winthrop Rapid Actrapid, Novolin R, ReliOn/Novolin R Names of Lilly r-DNA/GE/GM insulins worldwide | |
Use and Handling: | |
Shelf Life: 24 months | Type: soluble, clear |
When Opened: 28 days room temp. | |
In Pen: 28 days room temp. | |
Notes: Protect from light and heat Do Not Freeze, May be used intravenously |
UK brand name for Lilly's short-acting r-DNA/GE/GM human insulin [2][3][4][5].
The "S" in the product's name is an abbreviation for "soluble".
It's known in North America as Humulin R [6][7], elsewhere as Huminsulin Normal, and can also be referred to as Toronto insulin instead of the R classification.
Both Novo Nordisk [8] and Aventis produce comparable insulins.
Novo's names for them are Actrapid [9][10][11] and Novolin R; Aventis' is Insuman Rapid [12][13] and Winthrop Rapid.
Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed [14].
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [15] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously.
The very small insulin particles in semilente insulin are suspended by zinc [16]. Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins [17][18]. Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin [19].
R/Neutral Insulins
R/Neutral Insulins | |
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All Short acting All soluble | |
Hypurin Bovine Neutral Betasint Bovine Corriente | |
Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) Insuvet Neutral (No longer produced.) | |
Iletin I R (No longer produced.) | |
Betasint Porcine Corriente Hypurin Porcine Neutral Hypurin Pork Regular Maxirapid CHO | |
Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, Umuline Rapide Umuline Regular, Winthrop Rapid Humulin ReliOn R | |
R-DNA | ReliOn/Novolin R (No longer produced.) |
References
- ↑ Insulins. North American Veterinary Conference Clinicians Brief (2006).
- ↑ Patient Information Leaflet-Humulin S. Eli Lilly.
- ↑ Humulin S Prescribing Information.
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Humulin S. Medguides UK.
- ↑ Humulin R patient leaflet. Eli Lilly.
- ↑ Humulin R Regular Human Insulin. Revolution Health.
- ↑ Novolin R. Revolution Health.
- ↑ Patient Information Leaflet-Actrapid. Novo Nordisk.
- ↑ Scientific Discussion-Actrapid. EMEA.
- ↑ Prescribing Novo Insulins.
- ↑ Patient information Leaflet-Insuman Rapid. Sanofi-Aventis.
- ↑ Prescribing Insuman Insulins.
- ↑ Humulin R patient leaflet. Eli Lilly.
- ↑ DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University.
- ↑ DeRuiter, Jack. Insulin Preparations-Lente. Auburn University.
- ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins - ↑ Resource Guide. American Diabetes Association (2005).
- ↑ DeRuiter, Jack. Insulin Preparations-Lente Insulin. Auburn University.
More Information
- NACDS-Insulin Chart-Page 2
- Leeds NHS UK Insulin Guide
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of regular/neutral/normal insulins.
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