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A [[short-acting]], soluble, non-suspended insulin produced from [[r-DNA/GE/GM]], [[bovine]], or [[porcine]] sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available. |
A [[short-acting]], soluble, non-suspended insulin produced from [[r-DNA/GE/GM]], [[bovine]], or [[porcine]] sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available. |
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While both R/neutral and [[semilente]] insulins are considered [[:Category:Fast-acting|fast-acting]], they differ in a few ways. As above, there's no [[suspension]] or buffer <ref>{{cite web|url=http://www.duc.auburn.edu/~deruija/insulin_preparations.pdf |title=Insulin Preparations-Regular Insulin|author=DeRuiter, Jack|publisher=Auburn University}}</ref> in R/neutral; it's totally dissolved and [[soluble]], meaning it can safely be used [[:Category:Intravenous_use_YES|intravenously]]. |
While both R/neutral and [[semilente]] insulins are considered [[:Category:Fast-acting|fast-acting]], they differ in a few ways. As above, there's no [[suspension]] or buffer <ref>{{cite web|url=http://www.duc.auburn.edu/~deruija/insulin_preparations.pdf |title=Insulin Preparations-Regular Insulin|author=DeRuiter, Jack|publisher=Auburn University}}</ref> in R/neutral; it's totally dissolved and [[soluble]], meaning it can safely be used [[:Category:Intravenous_use_YES|intravenously]]. |
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Revision as of 11:13, 6 October 2010
Humulin S | |
R,Neutral by Eli Lilly | |
short-acting | r-DNA/GE/GM |
U100 | none |
Line | Humulin |
Also known as | Huminsulin Normal, Humulin C, Humulin R, Humulin Regular, Humulin ReliOn R, Humulina Regular, Humuline R, Humuline Regular, Umuline Rapide, Umuline Regular |
Similar to | |
Action in dogs |
|
Use and Handling | |
---|---|
Type | soluble |
Shelf Life | 24 months |
When opened | 28 days room temp. |
In pen | 28 days room temp. |
Notes |
|
UK brand name for Lilly's short-acting r-DNA/GE/GM human insulin [2][3][4][5].
The "S" in the product's name is an abbreviation for "soluble".
It's known in North America as Humulin R [6][7], elsewhere as Huminsulin Normal, and can also be referred to as Toronto insulin instead of the R classification.
Both Novo Nordisk [8] and Aventis produce comparable insulins.
Novo's names for them are Actrapid [9][10][11] and Novolin R; Aventis' is Insuman Rapid [12][13] and Winthrop Rapid.
Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed [14].
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [15] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously.
The very small insulin particles in semilente insulin are suspended by zinc [16]. Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins [17][18]. Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin [19].
R/Neutral Insulins
R/Neutral Insulins | |
---|---|
All Short acting All soluble | |
Hypurin Bovine Neutral, Insuvet Neutral Betasint Bovine Corriente | |
Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) | |
Iletin I R (No longer produced.) | |
Betasint Porcine Corriente Hypurin Porcine Neutral Hypurin Pork Regular Maxirapid CHO | |
Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, ReliOn/Novolin R Umuline Rapide, Umuline Regular Winthrop Rapid, Humulin ReliOn R |
References
- ↑ Insulins. North American Veterinary Conference (2005).
- ↑ Patient Information Leaflet-Humulin S. Eli Lilly.
- ↑ Humulin S Prescribing Information.
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Humulin S. Medguides UK.
- ↑ Humulin R patient leaflet. Eli Lilly.
- ↑ Humulin R Regular Human Insulin. Revolution Health.
- ↑ Novolin R. Revolution Health.
- ↑ Patient Information Leaflet-Actrapid. Novo Nordisk.
- ↑ Scientific Discussion-Actrapid. EMEA.
- ↑ Prescribing Novo Insulins.
- ↑ Patient information Leaflet-Insuman Rapid. Sanofi-Aventis.
- ↑ Prescribing Insuman Insulins.
- ↑ Humulin R patient leaflet. Eli Lilly.
- ↑ DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University.
- ↑ DeRuiter, Jack. Insulin Preparations-Lente. Auburn University.
- ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins - ↑ Resource Guide. American Diabetes Association (2005).
- ↑ DeRuiter, Jack. Insulin Preparations-Lente Insulin. Auburn University.
More Information
- NACDS-Insulin Chart-Page 2
- Leeds NHS UK Insulin Guide
- Insulin therapy for dogs and cats Dowling-Canadian Veterinary Journal-September 1995
A discussion of regular/neutral/normal insulins.