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A [[short-acting]], soluble, non-suspended insulin produced from [[r-DNA/GE/GM]], [[bovine]], or [[porcine]] sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
 
A [[short-acting]], soluble, non-suspended insulin produced from [[r-DNA/GE/GM]], [[bovine]], or [[porcine]] sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
 
[[Image:Rtap.gif|250px|thumb|left|'''Human''' activity profile for r-DNA/GE/GM R (Regular)/Neutral insulin. See links for dog activity.]]
{|align="left" width="250" border="1" bgcolor="powderblue"|
 
  +
|[[Image:Rtap.gif|250px]]
 
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|bgcolor="aliceblue"|'''Human''' activity profile for r-DNA/GE/GM R (Regular)/Neutral insulin. See links for dog activity.
 
|}
 
 
While both R/neutral and [[semilente]] insulins are considered [[:Category:Fast-acting|fast-acting]], they differ in a few ways. As above, there's no [[suspension]] or buffer <ref>{{cite web|url=http://www.duc.auburn.edu/~deruija/insulin_preparations.pdf |title=Insulin Preparations-Regular Insulin|author=DeRuiter, Jack|publisher=Auburn University}}</ref> in R/neutral; it's totally dissolved and [[soluble]], meaning it can safely be used [[:Category:Intravenous_use_YES|intravenously]].
 
While both R/neutral and [[semilente]] insulins are considered [[:Category:Fast-acting|fast-acting]], they differ in a few ways. As above, there's no [[suspension]] or buffer <ref>{{cite web|url=http://www.duc.auburn.edu/~deruija/insulin_preparations.pdf |title=Insulin Preparations-Regular Insulin|author=DeRuiter, Jack|publisher=Auburn University}}</ref> in R/neutral; it's totally dissolved and [[soluble]], meaning it can safely be used [[:Category:Intravenous_use_YES|intravenously]].
   

Revision as of 11:13, 6 October 2010

Humulin S
R,Neutral by Eli Lilly
short-acting r-DNA/GE/GM
U100 none
Line Humulin
Also known as Huminsulin Normal, Humulin C, Humulin R, Humulin Regular, Humulin ReliOn R, Humulina Regular, Humuline R, Humuline Regular, Umuline Rapide, Umuline Regular


Names of Lilly r-DNA/GE/GM insulins worldwide

Similar to  
Action in dogs  
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h [1]
Use and Handling
Type soluble
Shelf Life 24 months
When opened 28 days room temp.
In pen 28 days room temp.
Notes  
  • protect from light and heat
  • Do Not Freeze
  • May be used intravenously
21944f

Humulin S-a fast-acting, neutral, soluble insulin. Note package similarity of comparable insulin Insuman Rapid.


UK brand name for Lilly's short-acting r-DNA/GE/GM human insulin [2][3][4][5].

The "S" in the product's name is an abbreviation for "soluble".

It's known in North America as Humulin R [6][7], elsewhere as Huminsulin Normal, and can also be referred to as Toronto insulin instead of the R classification.

Both Novo Nordisk [8] and Aventis produce comparable insulins.

Novo's names for them are Actrapid [9][10][11] and Novolin R; Aventis' is Insuman Rapid [12][13] and Winthrop Rapid.

Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed [14].

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

Rtap

Human activity profile for r-DNA/GE/GM R (Regular)/Neutral insulin. See links for dog activity.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [15] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously.

The very small insulin particles in semilente insulin are suspended by zinc [16]. Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins [17][18]. Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin [19].

R/Neutral Insulins

References

  1. Insulins. North American Veterinary Conference (2005).
  2. Patient Information Leaflet-Humulin S. Eli Lilly.
  3. Humulin S Prescribing Information.
  4. Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
  5. Humulin S. Medguides UK.
  6. Humulin R patient leaflet. Eli Lilly.
  7. Humulin R Regular Human Insulin. Revolution Health.
  8. Novolin R. Revolution Health.
  9. Patient Information Leaflet-Actrapid. Novo Nordisk.
  10. Scientific Discussion-Actrapid. EMEA.
  11. Prescribing Novo Insulins.
  12. Patient information Leaflet-Insuman Rapid. Sanofi-Aventis.
  13. Prescribing Insuman Insulins.
  14. Humulin R patient leaflet. Eli Lilly.
  15. DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University.
  16. DeRuiter, Jack. Insulin Preparations-Lente. Auburn University.
  17. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there was only beef Lente-type insulin--no pork or r-DNA/GE/GMLente insulins
  18. Resource Guide. American Diabetes Association (2005).
  19. DeRuiter, Jack. Insulin Preparations-Lente Insulin. Auburn University.

More Information

A discussion of regular/neutral/normal insulins.