Canine Diabetes Wiki
Humulin ReliOn R
R, Neutral by Eli Lilly
U100 none
Action in dogs:
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h [1]
Line: Humulin
Also known as: Huminsulin Normal
Humulin CHumulin R, Humuline R
Humuline Regular, Humulin Regular
Humulina RegularHumulin S
Umuline Rapide, Umuline Regular
Similar to: Insuman Rapid, Winthrop Rapid
Actrapid, Novolin R, ReliOn/Novolin R

Names of Lilly r-DNA/GE/GM insulins worldwide
Use and Handling:
Shelf Life: 24 months Type: soluble, clear
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat
Do Not Freeze,
May be used intravenously

Human activity profile for r-DNA/GE/GM R (Regular)/Neutral insulin. See links for dog activity.

Humulin ReliOn R is one of several brands of "Regular" (short-acting) insulin, used for a quick consumption of blood sugar with little delay. ReliOn brand insulin wa formerly made by Novo Nordisk, who had been responsible for producing the ReliOn insulins since 2000. [2][3] The ReliOn insulins are still offered in the same types, R, NPH, and 70/30 mix, but they are produced by Eli Lilly and branded as Humulin/ReliOn insulins. [4][5][6] Novolin insulins have NOT been discontinued; these insulins are available as Novolin N, Novolin R, and Novolin 70/30. Only the ReliOn/Novolin branded insulins have been phased out.

It consists of zinc insulin crystals dissolved in clear fluid with no additives to alter its action or speed. [7]

Other brands with the same action profile include:

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [17] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [18]

The very small insulin particles in semilente insulin are suspended by zinc. [17] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [19][20] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [17]

R/Neutral Insulins[]


  1. Insulins. North American Veterinary Conference Clinicians Brief (2006).
  2. A Change to ReliOn Insulin. ReliOn.
  3. Low Cost Insulin Available through major retailer. Diabetes Health (1 December 2000).
  4. Wal-Mart Changes Insulin Partners. Wall Street Journal (22 June 2010).
  5. Wal-Mart Press Release (22 June 2010).
  6. ReliOn insulins. ReliOn.
  7. Humulin R patient leaflet. Eli Lilly.
  8. Novolin R Regular Human Insulin. Revolution Health.
  9. Patient Information Leaflet-Humulin S. Eli Lilly.
  10. Humulin S Prescribing Information.
  11. Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
  12. Patient Information Leaflet-Actrapid. Novo Nordisk.
  13. Scientific Discussion-Actrapid. EMEA.
  14. Prescribing Novo Insulins.
  15. Patient Information Leaflet-Insuman Rapid. Sanofi-Aventis.
  16. Prescribing Insuman Insulin.
  17. 17.0 17.1 17.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content
  18. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  19. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  20. Resource Guide. American Diabetes Association (2005).

More Information[]

Related Pages
Novolin R
Humulin R
Humulin S
Insuman Rapid