Humulin Regular
R, Neutral by Eli Lilly
U40, U100 none
Action in dogs:
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h [1]
Line: Humulin
Also known as: Huminsulin Normal
Humulin CHumulin R, Humuline R
Humulina Regular, Humuline Regular
Humulin SHumulin ReliOn R, Umuline Rapide
Umuline Regular
Similar to: Insuman Rapid, Winthrop Rapid
Actrapid, Novolin R, ReliOn/Novolin R

Names of Lilly r-DNA/GE/GM insulins worldwide
Use and Handling:
Shelf Life: 24 months Type: soluble, clear
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat
Do Not Freeze,
May be used intravenously

Humulin Regular time activity profile.

Note that some countries have the brand name in U40 strength.

Humulin Regular is one of several brands of "Regular" (short-acting) insulin, used for a quick consumption of blood sugar with little delay.

It consists of zinc insulin crystals dissolved in clear fluid with no additives to alter its action or speed. [2]

Other brands with the same action profile include:

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [12] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [13]

The very small insulin particles in semilente insulin are suspended by zinc. [12] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [14][15] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [12]

R/Neutral InsulinsEdit


  1. Insulins. North American Veterinary Conference Clinicians Brief (2006).
  2. Humulin R patent leaflet. Eli Lilly.
  3. Novolin R Regular Human Insulin. Revolution Health.
  4. Patient Information Leaflet-Humulin S. Eli Lilly.
  5. Humulin S Prescribing Information
  6. Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
  7. Patient Information Leaflet-Actrapid. Novo Nordisk.
  8. Scientific Discussion-Actrapid. EMEA.
  9. Prescribing Novo Insulins.
  10. Patient Information Leaflet-Insuman Rapid. Sanofi-Aventis.
  11. Prescribing Insuman Insulins.
  12. 12.0 12.1 12.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University.
  13. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  14. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  15. Resource Guide. American Diabetes Association (2005).

More InformationEdit

Related Pages
A1833110 HumilinLILLY 21944f DSC02818 Actrapid
Novolin R
Humulin R
Humulin S
Insuman Rapid
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