| Humulin M5 | |
|---|---|
| R/Neutral/NPH/Isophane Mix by Eli Lilly | |
| intermediate-acting | |
| r-DNA/GE/GM | |
| U40, U100 | isophane |
Action in dogs:
| |
| Line: Humulin | |
| Also known as: Huminsulin 50/50 Humulin 50/50, Humulina 50/50, Humuline 50/50 | |
| Similar to: Actraphane 50/50, Mixtard 50, Penmix 50 [1] Insuhuman Comb 50, Insuman Comb 50 Winthrop Comb 50 Names of Lilly r-DNA/GE/GM insulins worldwide | |
| Use and Handling: | |
| Shelf Life: 24 months | Type: cloudy |
| When Opened: 28 days room temp. | |
| In Pen: 28 days room temp. | |
| Notes: Protect from light and heat Do Not Freeze, Resuspend Do not use if product does not re-suspend Do not use intravenously [2] | |
Humulin M5.
Humulin M5 was the EU/UK brand name for Lilly's r-DNA/GE/GM human insulin mix consisting of 50% R/neutral insulin and 50% NPH/isophane crystal [3] insulin. [4]
Lilly stopped offering this insulin in the EU & UK in July 2004. [5][6]
It is the same as Humulin 50/50, Humuline 50/50, Humulina 50/50, Mixtard 50, [7] Actraphane 50/50 [8][9] and Aventis' Insuman Comb 50 [10][11] and Winthrop Comb 50.
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
| Non-Analog Mixed Insulins | ||
|---|---|---|
|
All Intermediate-acting | |
| Insulin Is | Expressed As | Expressed As |
| 10% R/Neutral Insulin 90% NPH/Isophane Insulin |
90/10 | 10/90 |
| 20% R/Neutral Insulin 80% NPH/Isophane Insulin |
80/20 | 20/80 |
| 30% R/Neutral Insulin 80% NPH/Isophane Insulin |
70/30 | 30/70 |
| 40% R/Neutral Insulin 60% NPH/Isophane Insulin |
60/40 | 40/60 |
| 50% R/Neutral Insulin 50% NPH/Isophane Insulin |
50/50 | 50/50 |
References[]
- ↑ Penmix 50. Medsafe NZ.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Scientific Discussion--Mixtard. EMEA.
- ↑ Humulin 50/50-NPH;R Human Insulin. Revolution Health.
- ↑ Withdrawal of Humulin M5. Diabetes UK (July 2004).
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Insulins & Mixtures. NHS.
- ↑ Scientific Discussion--Actraphane. EMEA.
- ↑ Prescribing Novo Insulins.
- ↑ Patient Information Leaflet-Insuman Comb 50. Sanofi-Aventis.
- ↑ Prescribing Insuman Insulins.
More Information[]
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