Canine Diabetes Wiki
Humulin C
R, Neutral by Eli Lilly
U40, U100 none
Action in dogs:
  • onset 10-30 minutes,
  • peak 1-5h,
  • duration 4-10h [1]
Line: Humulin
Also known as: Huminsulin Normal
Humulin RHumuline R, Humulin Regular
Humulina Regular, Humuline Regular
Humulin SHumulin ReliOn R, Umuline Rapide
Umuline Regular
Similar to: Insuman Rapid, Winthrop Rapid
Actrapid, Novolin R, ReliOn/Novolin R

Names of Lilly r-DNA/GE/GM insulins worldwide
Use and Handling:
Shelf Life: 24 months Type: soluble, clear
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat
Do Not Freeze,
May be used intravenously


Humulin C time activity profile.

Humulin C is one of several brands of "Regular" (short-acting) insulin, used for a quick consumption of blood sugar with little delay. The "C" stands for corriente, which is Spanish for "regular" or "neutral". Though they are made from beef and from pork, the Beta Laboratorios two short-acting insulins have "corriente" in their names: Betasint Bovine Corriente and Betasint Porcine Corriente. Both are also short-acting insulins like Humulin C and have similar time activity profiles.

It consists of zinc insulin crystals dissolved in clear fluid with no additives to alter its action or speed. [2]

Other brands with the same action profile include:

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [12] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [13]

The very small insulin particles in semilente insulin are suspended by zinc. [12] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [14][15] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [12]

R/Neutral Insulins[]


  1. Insulins. North American Veterinary Conference Clinicians Brief (2006).
  2. Humulin R patient leaflet. Eli Lilly.
  3. Novolin R Regular Human Insulin. Revolution Health.
  4. Patient Information Leaflet-Humulin S. Eli Lilly.
  5. Humulin S Prescribing Information.
  6. Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
  7. Patient Information Leaflet-Actrapid. Novo Nordisk.
  8. Scientific Discussion-Actrapid. EMEA.
  9. Prescribing Novo Insulins.
  10. Patient Information Leaflet-Insuman Rapid. Sanofi-Aventis.
  11. Prescribing Insuman Insulins.
  12. 12.0 12.1 12.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content
  13. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  14. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  15. Resource Guide. American Diabetes Association (2005).

More Information[]

Related Pages
A1833110 HumilinLILLY 21944f DSC02818 Actrapid
Novolin R
Humulin R
Humulin S
Insuman Rapid