Huminsulin Normal | |
---|---|
R, Neutral by Eli Lilly | |
short-acting | |
r-DNA/GE/GM | |
U40, U100 | none |
Action in dogs:
| |
Line: Humulin | |
Also known as: Humulin C, Humulin R, Humuline R, Humulin Regular, Humulina Regular Humuline Regular, Humulin S, Humulin ReliOn R, Umuline Rapide, Umuline Regular | |
Similar to: Insuman Rapid, Winthrop Rapid Actrapid, Novolin R, ReliOn/Novolin R Names of Lilly r-DNA/GE/GM insulins worldwide | |
Use and Handling: | |
Shelf Life: 24 months | Type: soluble, clear |
When Opened: 28 days room temp. | |
In Pen: 28 days room temp. | |
Notes: Protect from light and heat Do Not Freeze, May be used intravenously |
Note that some countries have the brand name in U40 strength. |
Huminsulin Normal is one of several brands of "Regular" or "neutral" (short-acting) insulin, used for a quick consumption of blood sugar with little delay. It's known in North America as Humulin R. [2][3]
It consists of zinc insulin crystals dissolved in clear fluid with no additives to alter its action or speed. [2]
Other brands with the same action profile include:
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer. [13] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [14]
The very small insulin particles in semilente insulin are suspended by zinc. [13] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [15][16] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [13]
R/Neutral Insulins[]
R/Neutral Insulins | |
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All Short acting All soluble | |
Hypurin Bovine Neutral Betasint Bovine Corriente | |
Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) Insuvet Neutral (No longer produced.) | |
Iletin I R (No longer produced.) | |
Betasint Porcine Corriente Hypurin Porcine Neutral Hypurin Pork Regular Maxirapid CHO | |
Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, Umuline Rapide Umuline Regular, Winthrop Rapid Humulin ReliOn R | |
R-DNA | ReliOn/Novolin R (No longer produced.) |
References[]
- ↑ Insulins. North American Veterinary Conference Clinicians Brief (2006).
- ↑ 2.0 2.1 Humulin R patient leaflet. Eli Lilly.
- ↑ Humulin R Regular Human Insulin. Revolution Health.
- ↑ Novolin R Regular Human Insulin. Eli Lilly.
- ↑ Patient Information Leaflet-Humulin S. Eli Lilly.
- ↑ Humulin S Prescribing Information.
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Patient Information Leaflet-Actrapid. Novo Nordisk.
- ↑ Scientific Discussion-Actrapid. EMEA.
- ↑ Prescribing Novo Insulins.
- ↑ Patient Information Leaflet-Insuman Rapid. Sanofi-Aventis.
- ↑ Prescribing Insuman Insulins.
- ↑ 13.0 13.1 13.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid
<ref>
tag; name "Auburn" defined multiple times with different content Cite error: Invalid<ref>
tag; name "Auburn" defined multiple times with different content - ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
Note--in 1980, there were no r-DNA/GE/GM insulins - ↑ Resource Guide. American Diabetes Association (2005).
More Information[]
- NACDS-Insulin Chart-Page 2
- Leeds NHS UK Insulin Guide
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of regular/normal/neutral insulins.
Related Pages | ||||
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