FDA Warning Letter to Eli Lilly re: instability of insulin Lispro (Humalog) crystals-10 February 2010
Reuters News story re: Lilly/Humalog Warning Letter-23 February 2010
Humalog 75 25

Humalog Mix 75/25, known also as Humalog Mix 25.

Eli Lilly brand name for their mix of 25% insulin lispro and 75% insulin lispro protamine suspension. [1] Also known as Humalog Mix 25, it is an intermediate-acting insulin. The 75% fraction that is NPL (Neutral Protamine Lispro) [2] is a suspension of crystals formed by combining insulin lispro and protamine.

A study of dogs from 1993-1994 using various fractions of Humalog mixes against human NPH/isophane insulin found only minor differences in the use of Humalog Mix as opposed to NPH/isophane insulin. [3]

Analog Insulins: amino acid sequencesEdit

Analog Insulin pharmacokineticsEdit

These are human activity profiles.


More InformationEdit

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