Canine Diabetes Wiki

Now we're going to look at how to combine two insulins-one faster-acting and clear and one slower-acting and cloudy. The cloudy insulin will need to be resuspended before using it.

Before each use, take a moment to inspect the insulin prior to drawing it into the syringe; clear insulins should appear not discolored and clear; suspended insulins should be uniform in their cloudiness. [1][2]

Bad insulin

Three visual examples of damaged insulin.

Do not use the insulin if:

  • Clear insulin that looks discolored or has turned cloudy, contains particles or haze. [8]
  • Cloudy insulin that appears yellowish or remains lumpy or clotted after mixing. [9][7]

See Insulin problems for more information about "bad" insulin.

If you need to learn how to draw only one insulin in the syringe, see Drawing insulin.


  1. Insulin Therapy-Stability & Storage.
  2. Keeping an Eye on Your Insulin. Diabetes Health (2001).
  3. Benson EA, Benson JW Jr, Fredlund PN, Mecklenburg RS, Metz R. (1988). Flocculation & Loss of Potency of Human NPH Insulin. Diabetes Care-American Diabetes Association.
  4. Playán J, Acha J, Navarro H, Sanz A, Guallar AM, Albero R. (1994). Flocculation of NPH Insulin. Revista Clinica Espanola-(English Translation).
  5. 5.0 5.1 Rosskamp, Ralf H., Park, Glen (1988). Frosting Caused in NPH/Isophane Insulin By Heat/Cold.
  6. Definition of Flocculation. Dorlands Medical Dictionary.
  7. 7.0 7.1 7.2 Storage & Safety-Frosting of NPH, Lente, Ultralente Insulins-Page 5. Diabetes Forecast (2006). Cite error: Invalid <ref> tag; name "Storage" defined multiple times with different content Cite error: Invalid <ref> tag; name "Storage" defined multiple times with different content
  8. Humalog & Heat.
  9. 9.0 9.1 Injection Insulin-Transcript of American Diabetes Association Videotape. American Diabetes Association (2003).
  10. Diabetes Mellitus. Washington State University.

More Information[]