British Pharmacopia defines them as: A sterile solution of insulin (i.e. bovine or porcine) or of human insulin; pH 6.6-8.0[1].
Short acting insulins have been around a long time. The first insulin produced for treatment of diabetes was short-acting; there was no such thing as longer acting insulins until the mid 1930's when PZI came on the market. Until then, most diabetics had to rely on a series of shots to get them through each day.[2]
Today short-acting insulin is used as bolus for meals, for blood glucose corrections when bg's are running too high, and for diabetic emergencies. When a pet or person is hospitalized for a diabetic emergency, some type of short or rapid-acting insulin is given intravenously to bring blood glucose levels down quickly.[3]
These short-acting insulins are used either by themselves as bolus or corrective insulin or as mixed insulins, combined with NPH/isophane insulin.
With the exception of semilente, they can be injected or given intravenously. Semilente can't be used intravenously because it is a suspended, "cloudy" insulin.[4] Semilente by itself has almost disappeared from the market.
Short and fast-acting insulins are sometimes referred to as prandial insulins because of their regular use to cover food eaten at meals.[5]
Trade names:
Insulin analogs can be found under the Category:Fast-acting.
References[]
- ↑ Neutral insulin. InChem.
- ↑ Chase, Lilliam A. (September 1938). Some Rules for Dosage of Protamine Zinc Insulin. Canadian Medical Journal.
- ↑ Dowling, Patricia M. (September 1995). Insulin therapy for dogs and cats.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Heinemann, Lutz (January 2008). Variability of Insulin Action:Does It Matter?-page 40 (4 of 9). Insulin Journal.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
More Information[]
- NACDS-Insulin Chart-Page 2
- Lente Insulins-Injectable Suspensions West Virginia University College of Pharmacy-2009
- Discussing use of short acting insulin along with a longer-acting one Richared, Mike, Vet Info 4 Dogs
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