Canine Diabetes Wiki
Insulin depot

The insulin depot, shown here as subcutaneous depot, is the source of any carryover insulin.

Carryover or carry-over refers to insulin effects lasting past the insulin's official duration. It's been observed that some intermediate-acting and long-acting insulins leave an Insulin Depot [1] under the skin that has a small residual effect that may last anywhere from 12 to 48 hours, after the principal action has ended. The carryover effect is what keeps insulin levels stable. [2]

Keep in mind that any substance injected into the body will be removed or broken down gradually, it won't all disappear at once. So even after there's not enough insulin left to make a noticeable dent in blood glucose, there will still be a period of time when small amounts are present and being slowly used up.

For terminology's sake, consider the principal action of the insulin to be its onset, peak, and duration. If you shoot insulin again before the duration has expired, there will be overlap. Carryover is whatever small residual effect is left after duration has expired. I16


  1. Hanas, Ragnar (1999). Insulin Dependent Diabetes-Insulin Depot-page 10. ChildrenWithDiabetes.
  2. Missed dose of glargine insulin. Net Wellness-University of Cincinnati (2006).