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Betasint Porcine NPH

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Betasint Porcine NPH
NPH/isophane by Beta Laboratorios
intermediate-acting
Porcine
U40, U80, U100 isophane
Action in dogs:
  • onset within 2h,
  • peak 6-12h,
  • duration 18-14h
Line: Betasint
Also known as: Pork NPH, pork isophane
Similar to: Hypurin Porcine Isophane
Hypurin Pork NPH, Pork Insulatard, [1] Iletin II NPH
Leo Retard [2]
Use and Handling:
Shelf Life: 36 months Type: cloudy
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat
Do Not Freeze, Re-suspend
Do not use if product does not re-suspend

Cartridges in use are not to be refrigerated
Do not use intravenously [3]
May be used intramuscularly, which means onset, peak and duration times are shorter.

Betasint

Betasint logo. Bovine insulin was successfully extracted in January 1987-porcine followed in June of the same year.


This intermediate-acting pork isophane insulin [4][5] is similar to CP Pharma's Hypurin Porcine Isophane/Hypurin Pork NPH [6][7] and the former insulins of both Lilly--Iletin II NPH [8] and Novo [9][10]-Pork Insulatard. [11][12][13]

Specifications of NPH/isophane insulin[]

British National Formulary [14] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.

British Pharmacoepia and United States Pharmacopia definitions: [14]

Isophane Insulin

Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.

USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.


NPH/isophane insulins[]

The following commercial insulins are all generically NPH insulins:


Other commonly used names are:

  • NPH insulin, NPH
  • isophane insulin

References[]

  1. ↑ 1.0 1.1 1.2 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
  2. ↑ Montgomery, D. A. D.. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  3. ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  4. ↑ Betasint Porcine NPH. Beta Laboratorios.
  5. ↑ Google Translation of Betasint Porcine NPH page.
  6. ↑ Hypurin Porcine Isophane Patient Information. Net Doctor.co.uk.
  7. ↑ Hypurin Porcine Isophane. Wockhardt UK.
  8. ↑ US-FDA Iletin II N Discontinuation Notice. Eli Lilly (July 2005).
  9. ↑ 9.0 9.1 Prescribing Porcine Insulin.
  10. ↑ 10.0 10.1 Prescribing Novo Animal Insulin.
  11. ↑ Pork Insulatard patient Information. NetDoctor UK.
  12. ↑ Pork Insulatard. Novo Nordisk.
  13. ↑ Pork Insulatard Discontinuation Notice. Wockhardt UK.
  14. ↑ 14.0 14.1 British National Formulary-Isophane/NPH Insulin Definition. InChem. Cite error: Invalid <ref> tag; name "InChem" defined multiple times with different content
  15. ↑ Hypurin Bovine Isophane Patient Information. Net Doctor UK.
  16. ↑ Hypurin Bovine Isophane. Wockhardt UK.
  17. ↑ Prescribing Bovine Insulin.
  18. ↑ Patient Information Leaflet-Pork Insulatard. Novo Nordisk.

More Information[]

Related Pages
Iletin II N
Hypurin Porcine Isophane
Pork Insulatard
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