Canine Diabetes Wiki
Betasint Porcine NPH
NPH/isophane by Beta Laboratorios
U40, U80, U100 isophane
Action in dogs:
  • onset within 2h,
  • peak 6-12h,
  • duration 18-14h
Line: Betasint
Also known as: Pork NPH, pork isophane
Similar to: Hypurin Porcine Isophane
Hypurin Pork NPH, Pork Insulatard, [1] Iletin II NPH
Leo Retard [2]
Use and Handling:
Shelf Life: 36 months Type: cloudy
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat
Do Not Freeze, Re-suspend
Do not use if product does not re-suspend

Cartridges in use are not to be refrigerated
Do not use intravenously [3]
May be used intramuscularly, which means onset, peak and duration times are shorter.


Betasint logo. Bovine insulin was successfully extracted in January 1987-porcine followed in June of the same year.

This intermediate-acting pork isophane insulin [4][5] is similar to CP Pharma's Hypurin Porcine Isophane/Hypurin Pork NPH [6][7] and the former insulins of both Lilly--Iletin II NPH [8] and Novo [9][10]-Pork Insulatard. [11][12][13]

Specifications of NPH/isophane insulin[]

British National Formulary [14] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.

British Pharmacoepia and United States Pharmacopia definitions: [14]

Isophane Insulin

Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.

USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.

NPH/isophane insulins[]

The following commercial insulins are all generically NPH insulins:

Other commonly used names are:

  • NPH insulin, NPH
  • isophane insulin


  1. 1.0 1.1 1.2 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
  2. Montgomery, D. A. D.. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  3. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  4. Betasint Porcine NPH. Beta Laboratorios.
  5. Google Translation of Betasint Porcine NPH page.
  6. Hypurin Porcine Isophane Patient Information. Net
  7. Hypurin Porcine Isophane. Wockhardt UK.
  8. US-FDA Iletin II N Discontinuation Notice. Eli Lilly (July 2005).
  9. 9.0 9.1 Prescribing Porcine Insulin.
  10. 10.0 10.1 Prescribing Novo Animal Insulin.
  11. Pork Insulatard patient Information. NetDoctor UK.
  12. Pork Insulatard. Novo Nordisk.
  13. Pork Insulatard Discontinuation Notice. Wockhardt UK.
  14. 14.0 14.1 British National Formulary-Isophane/NPH Insulin Definition. InChem. Cite error: Invalid <ref> tag; name "InChem" defined multiple times with different content
  15. Hypurin Bovine Isophane Patient Information. Net Doctor UK.
  16. Hypurin Bovine Isophane. Wockhardt UK.
  17. Prescribing Bovine Insulin.
  18. Patient Information Leaflet-Pork Insulatard. Novo Nordisk.

More Information[]

Related Pages
Hypurin pork n
Pork Insulatard
Iletin II N
Hypurin Porcine Isophane
Pork Insulatard