Canine Diabetes Wiki
Betasint Porcine Corriente
R, Neutral by Beta Laboratorios
U40, U80, U100 none
Action in dogs:
  • onset 30-60 minutes,
  • peak 2-4h,
  • duration 6-8h
Line: Betasint
Also known as: Pork R, pork neutral
Similar to: Hypurin Porcine Neutral
Hypurin Pork Regular, Maxirapid CHO, Iletin II R
Leo Neutral,[1] Pork Actrapid
Use and Handling:
Shelf Life: 36 months Type: soluble, clear
When Opened: 6 weeks room temp.
In Pen: 6 weeks room temp.
Notes: Protect from light and heat
Do Not Freeze,
Cartridges in use are not to be refrigerated
May be used intravenously
May be used intramuscularly

Betasint logo. Bovine insulin was successfully extracted in January 1987-porcine followed in June of the same year.

Betasint Porcine Corriente [2][3] is a pork-based, short-acting insulin made by Beta Laboratorios. Maxirapid CHO is similar, as is CP Pharma's [4] Hypurin Porcine Neutral/Hypurin Pork Regular.

Eli Lilly's Iletin II R [5] was comparable, as was Novo Nordisk's Pork Actrapid. [6][7][8][9]which was discontinued at the end of December 2007[10]

As with all R/neutral insulins, regardless of species, nothing has been added to alter the speed or action of the insulin. [11][12]

A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.

While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [13] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [14] The very small insulin particles in semilente insulin are suspended by zinc. [13] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.

R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [15][16] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [13]

R/Neutral Insulins[]


  1. Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  2. Betasint Porcine Corriente.
  3. Google Translation of Betasint Porcine Corriente page.
  4. Hypurin Porcine Neutral. Wockhardt UK.
  5. US-FDA Iletin II R Discontinuation Notice. Eli Lilly (July 2005).
  6. Pork Actrapid Patient Information. Net Doctor UK.
  7. Patient Information Leaflet-Pork Actrapid. Novo Nordisk.
  8. Prescribing Porcine Insulin.
  9. Prescribing Novo Animal Insulin.
  10. Pork Actrapid Discontinuation Notice. Wockhardt UK.
  11. Hypurin Porcine Neutral Patient Information. Wockhardt UK.
  12. Humulin R. Eli Lilly.
  13. 13.0 13.1 13.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content Cite error: Invalid <ref> tag; name "Auburn" defined multiple times with different content
  14. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  15. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  16. Resource Guide. American Diabetes Association (2005).

More Information[]

Related pages
Hypurin pork r
Pork Actrapid
Insulinum Maxrapid 400px
Iletin II R
Hypurin Porcine Neutral
Pork Actrapid
Maxirapid CHO